scholarly journals Extracellular Vesicle-functionalized Decalcified Bone Matrix Scaffolds with Enhanced Pro-angiogenic and Pro-bone Regeneration Activities

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Hui Xie ◽  
Zhenxing Wang ◽  
Liming Zhang ◽  
Qian Lei ◽  
Aiqi Zhao ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Matrix ◽  
Extracellular Vesicle ◽  
Decalcified Bone Matrix

A cancellous bone matrix system with specific mineralisation degrees for mesenchymal stem cell differentiation and bone regeneration

2019 ◽  
Vol 7 (6) ◽  
pp. 2452-2467 ◽  
Author(s):  
Shijie Liu ◽  
Yiyun Wang ◽  
Jian Wang ◽  
Pengcheng Qiu ◽  
Shengyu Wang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Mesenchymal Stem Cell ◽  
Bone Regeneration ◽  
Cancellous Bone ◽  
Bone Matrix ◽  
Stem Cell Differentiation ◽  
Matrix System ◽  
Mesenchymal Stem Cell Differentiation ◽  
Regenerative Therapies

Bone regenerative therapies have been explored using various biomaterial systems.

The Poor Osteoinductive Capability of Human Acellular Bone Matrix

2012 ◽  
Vol 35 (12) ◽  
pp. 1061-1069 ◽  
Author(s):  
Yi-Zhou Huang ◽  
Jia-Qin Cai ◽  
Jing Xue ◽  
Xiao-He Chen ◽  
Chao-Liang Zhang ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Structural Features ◽  
Nodule Formation ◽  
Porous Network ◽  
Native Bone ◽  
Genes Encoding ◽  
Osteoid Formation ◽  
Stem Cell Niches

Demineralized bone matrix (DBM) has extensive clinical use for bone regeneration because of its osteoinductive and osteoconductive aptitude. It is suggested that the demineralization process in bone matrix preparation is influential in maintaining osteoinductivity; however, relevant investigations, especially into the osteoinductivity of acellular bone matrix, are not often performed. This study addressed the osteoinductive capability of human acellular cancellous bone matrix (ACBM) after subcutaneous implantation in a rat model. The growth and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rBM-MSCs) seeded in this material were also studied. Without the demineralization process, the ACBM we obtained had an interconnected porous network and the micropores in the surface were clearly exposed. After the ACBM was subcutaneously implanted for 4 months, new osteoid formation was noted but not typical mature bone formation. rBM-MSCs grew well in the ACBM and kept a steady morphology after continuous culture for 28 days. However, no mineralized nodule formation was detected and the expression levels of genes encoding osteogenic markers were significantly decreased. These results demonstrated that human ACBM possess the structural features of native bone and poor osteoinductivity; nonetheless this material helped to preserve the undifferentiated phenotype of rBM-MSCs. Such insights may further broaden our understanding of the application of ACBM for bone regeneration and the creation of stem cell niches.

Decalcified bone matrix increases the osteogenic potential of bone marrow

Bone ◽  
1985 ◽  
Vol 6 (4) ◽  
pp. 280-280
Author(s):  
E. Green ◽  
C. Hinton ◽  
J.T. Triffitt
Keyword(s):  
Bone Marrow ◽  
Bone Matrix ◽  
Osteogenic Potential ◽  
Decalcified Bone Matrix

Facilitating Osteogenesis of Chitosan with Autogenous Bone Marrow (experimental Study on Rabbits)

2020 ◽  
Vol 23 (2) ◽  
pp. 36-40
Author(s):  
Hawar Asaad Zebari ◽  
Hareth H. Kaskos
Keyword(s):  
Bone Marrow ◽  
Bone Mass ◽  
Bone Regeneration ◽  
Bone Matrix ◽  
Density Measurement ◽  
Autogenous Bone ◽  
Bone Density Measurement ◽  
Matrix Mineralization ◽  
Significant Difference ◽  
Measurement Results

Bone quality is the result of a complex relationship between the intrinsic properties of the materials that comprise the bone matrix mineralization, bone mass and the spatial distribution of the bone mass. Chitosan has been shown to be suitable bone replacement material. To evaluate the accelerating effect of chitosan on the bone regeneration process and assessing by CT Scan were conduct this study. Several important biological effect of chitosan has been characterized, these are high osteoinductivity, osteointegrability and gradual biodegrability that make it a good candidate for bone regeneration. Materials and Methods: 20 rabbits of both sex were enrolled in this study, two monocortical defects were created on Mandible, one considered as control and the other implanted with chitosan, other two monocortical defects were created on Tibia on the same animal. Post-operative follow up date 7,14,21and 28 Days. C.T. scan was used as parameter for bone density measurement. Results: showed that non- significant difference at Day7 and14 in Mandible and significant at Day21 and 28 compared to control, While non-significant at Day 7 in Tibia and significant at 14 and 21 post-operatively with highly significant at Day28 compared to control. Conclusion: Chitosan has ability to osteogenesis when it is used alone and the process of osteogenesis was facilitating when it is mixed with Bone marrow.

Sign in / Sign up

Export Citation Format

Share Document