scholarly journals A novel treatment for metastatic lymph nodes using lymphatic delivery and photothermal therapy

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Adewale O. Oladipo ◽  
Oluwatobi S. Oluwafemi ◽  
Sandile P. Songca ◽  
Ariunbuyan Sukhbaatar ◽  
Shiro Mori ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Photothermal Therapy ◽  
Metastatic Lymph Nodes ◽  
Novel Treatment ◽  
Metastatic Lymph ◽  
Lymphatic Delivery

scholarly journals Novel Multifunctional Nanoagent for Visual Chemo/Photothermal Therapy of Metastatic Lymph Nodes via Lymphatic Delivery

ACS Omega ◽  
2020 ◽  
Vol 5 (7) ◽  
pp. 3194-3206 ◽  
Author(s):  
Juan Cheng ◽  
Ying Liu ◽  
Lingyun He ◽  
Weiwei Liu ◽  
Yuli Chen ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Photothermal Therapy ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph ◽  
Lymphatic Delivery

scholarly journals The Therapeutic Effect of Second Near-Infrared Absorbing Gold Nanorods on Metastatic Lymph Nodes via Lymphatic Delivery System

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1359
Author(s):  
Adewale O. Oladipo ◽  
Thabang C. Lebepe ◽  
Vuyelwa Ncapayi ◽  
Ncediwe Tsolekile ◽  
Sundararajan Parani ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Laser Irradiation ◽  
Gold Nanorods ◽  
Axillary Lymph Node ◽  
Axillary Lymph ◽  
Metastatic Lymph Nodes ◽  
Non Invasive ◽  
Metastatic Lymph ◽  
Lymphatic Delivery

Photothermal therapy has been established recently as a non-invasive treatment protocol for cancer metastatic lymph nodes. Although this treatment approach shows efficient tumour ablation towards lymph node metastasis, the monitoring and reporting of treatment progress using the lymphatic delivery channel still need to be explored. Herein, we investigated the anti-tumour effect of pegylated gold nanorods with a high aspect ratio (PAuNRs) delivered via the lymphatic route in a mouse model. In this study, breast carcinoma (FM3A-Luc) cells were inoculated in the subiliac lymph node (SiLN) to induce metastasis in the proper axillary lymph node (PALN). The treatment was initiated by injecting the PAuNRs into the accessory axillary lymph node (AALN) after tumour metastasis was confirmed in the PALN followed by external NIR laser irradiation under a temperature-controlled cooling system. The anti-tumour impact of the treatment was evaluated using an in vivo bioluminescence imaging system (IVIS). The results showed a time-dependent reduction in tumour activity with significant treatment response. Tumour growth was inhibited in all mice treated with PAuNRs under laser irradiation; results were statistically significant (** p < 0.01) even after treatment was concluded on day 3. We believe that this non-invasive technique would provide more information on the dynamics of tumour therapy using the lymphatically administered route in preclinical studies.

scholarly journals New Application of Old Material: Chinese Traditional Ink for Photothermal Therapy of Metastatic Lymph Nodes

ACS Omega ◽  
2017 ◽  
Vol 2 (8) ◽  
pp. 5170-5178 ◽  
Author(s):  
Sheng Wang ◽  
Yongbin Cao ◽  
Qin Zhang ◽  
Haibao Peng ◽  
Lei Liang ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Photothermal Therapy ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph

scholarly journals A novel targeted multifunctional nanoplatform for visual chemo-hyperthermia synergy therapy on metastatic lymph nodes via lymphatic delivery

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Weiwei Liu ◽  
Xiaoping Ye ◽  
Lingyun He ◽  
Juan Cheng ◽  
Wenpei Luo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Carbon Nanoparticles ◽  
Combined Chemotherapy ◽  
Metastatic Lymph Nodes ◽  
Node Metastasis ◽  
Metastatic Lymph ◽  
Lymphatic Delivery

Abstract Background Distant metastasis to vital organs is the major contributor to breast cancer mortality, and regional lymph node metastasis is an important facilitator of distant metastasis and recurrence in this cancer. The early diagnosis and precise treatment of lymph node metastasis are crucial for staging and prognosis in breast cancer. Herein, we report a visualized precision medicine nanoplatform of metastatic lymph nodes for ultrasonic/photoacoustic (US/PA) dual modal imaging-guided in situ targeted hyperthermia-combined chemotherapy. Results Carbon nanoparticles (CNs), approved by the China Food and Drug Administration, were loaded with docetaxel and rationally combined with anti-hypoxia-inducible factor 1α antibody-modified poly (lactic-co-glycolic acid) (PLGA) nanoparticles to achieve the combination of passive targeting at the lymph nodes and intracellular targeting at HIF 1α factor. The accumulation and retention of nanoparticles in metastatic lymph nodes via lymphatic delivery were enhanced. Docetaxel could be effectively offloaded by CNs that have active carbon nanoparticles, and the PLGA membrane prevented drug leakage. The nanoparticles exhibited excellent photothermal performance with a photothermal conversion efficiency of 28.9%, killing tumor cells in metastatic lymph nodes through hyperthermia. In vitro and in vivo systematic evaluations revealed that hyperpyrexia triggered the rupture of nanoparticles caused by the phase transition of perfluorohexane, resulting in docetaxel release for achieving in situ hyperthermia-combined chemotherapy. Conclusions The laser-triggered highly efficient in situ chemotherapy nanosystem achieves targeted synergistic chemo-hyperthermia treatment of metastatic lymph nodes, and lymphatic delivery represents a strategy to avoid additional injury caused by drugs entering the blood circulation. Graphical Abstract

Differentiation of Hyperplastic from Metastatic Lymph Nodes Using a Lymph Node Specific MR Contrast Agent Gadofluorine M

2006 ◽  
Vol 55 (2) ◽  
pp. 183 ◽  
Author(s):  
Joo Hee Cha ◽  
Woo Kyung Moon ◽  
Jung Eun Cheon ◽  
Young Hwan Koh ◽  
Eun Hye Lee ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Contrast Agent ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph ◽  
Gadofluorine M

ENT private eye for unknown primary metastatic lymph nodes

ORL ro ◽  
2019 ◽  
Vol 1 (42) ◽  
pp. 20
Author(s):  
Daniela Vrînceanu ◽  
Mihai Dumitru ◽  
Adriana Nica
Keyword(s):  
Lymph Nodes ◽  
Unknown Primary ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph ◽  
Private Eye
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