scholarly journals Real-time sentinel lymph node biopsy guidance using combined ultrasound, photoacoustic, fluorescence imaging: in vivo proof-of-principle and validation with nodal obstruction

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jeeun Kang ◽  
Jin Ho Chang ◽  
Sun Mi Kim ◽  
Hak Jong Lee ◽  
Haemin Kim ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Real Time ◽  
Fluorescence Imaging ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Proof Of Principle

Comparison of Real-Time Fluorescent Indocyanine Green and 99mTc-Nanocolloid Radiotracer Navigation in Sentinel Lymph Node Biopsy of Penile Cancer

2015 ◽  
Vol 13 (6) ◽  
pp. 574-580 ◽  
Author(s):  
Marcin Markuszewski ◽  
Wojciech Polom ◽  
Wojciech Cytawa ◽  
Piotr Czapiewski ◽  
Piotr Lass ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Indocyanine Green ◽  
Real Time ◽  
Penile Cancer ◽  
Lymph Node Biopsy ◽  
Node Biopsy

257. Sentinel Lymph Node Biopsy with Real-time 3D Virtual Navigation

2012 ◽  
Vol 38 (9) ◽  
pp. 815 ◽  
Author(s):  
M. Suzuki ◽  
K. Koda ◽  
M. Yamazaki ◽  
T. Tezuka ◽  
C. Kosugi ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Real Time ◽  
Lymph Node Biopsy ◽  
Virtual Navigation ◽  
Node Biopsy

scholarly journals Real-time in situ navigation system with indocyanine green fluorescence for sentinel lymph node biopsy in patients with breast cancer

2020 ◽  
Author(s):  
Zhaorui Wang ◽  
Xiaowei Yang ◽  
Peng Liu ◽  
Chunguang Han ◽  
Yubo Pan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Indocyanine Green ◽  
Real Time ◽  
Lymph Node Biopsy ◽  
Green Fluorescence ◽  
Indocyanine Green Fluorescence ◽  
Node Biopsy

Abstract Background: The naked-eye invisibility of indocyanine green fluorescence limits the application of near-infrared fluorescence imaging (NIR) systems for real-time navigation during sentinel lymph node biopsy (SLNB) in patients with breast cancer undergoing surgery. This study aims to evaluate the effectiveness and safety of a novel NIR system in visualizing indocyanine green fluorescence images in the surgical field and the application value of combined methylene blue (MB) and the novel NIR system in SLNB. Methods: Sixty patients with clinical node-negative breast cancer received indocyanine green (ICG) and MB as tracers. Two NIR system instruments, namely, lymphatic fluorescence imaging system (LFIS) designed by the University of Science and Technology of China and vascular imager by Langfang Mingde Medical Biotechnology Co., Ltd. (Langfang vascular imager), were used as navigation assistance to locate sentinel lymph nodes (SLNs). Excising the lymph nodes developed by both MB and ICG by two NIR systems or palpably suspicious as SLNs and undergoing rapid pathological examination. Results: Both instruments exhibited 95% (57/60) success for real-time lymphatic fluorescent images. A total of 186 SLNs were identified, of which two were pathologically confirmed as lacking any lymph node tissue. SLN identification rate was 100% (184/184) for MB plus LFIS and 86.96% (160/184) for MB alone. The average number of SLNs identified by LFIS combined with MB was 3 (range of 1–8), which was significantly higher than that by MB alone at 2 (range 1–7) (P<0.05). Conclusion: LFIS effectively detects SLNs in breast cancer, projects the fluorescence signals during surgery, and provides a continuous surgical navigation system without the need for a remote monitor. The ICG method navigated by combined LFIS and MB may be a promising alternative tracer for radioisotope in SLN mapping.

scholarly journals Optimising magnetic sentinel lymph node biopsy in an in vivo porcine model

2015 ◽  
Vol 11 (4) ◽  
pp. 993-1002 ◽  
Author(s):  
Muneer Ahmed ◽  
Bauke Anninga ◽  
Joost J. Pouw ◽  
Suzan Vreemann ◽  
Mirjam Peek ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Porcine Model ◽  
Lymph Node Biopsy ◽  
Node Biopsy

scholarly journals 160. Optimising magnetic sentinel lymph node biopsy in an in vivo porcine model

2014 ◽  
Vol 40 (11) ◽  
pp. S70-S71
Author(s):  
M. Ahmed ◽  
B. Anninga ◽  
J. Pouw ◽  
S. Vreeman ◽  
M. Peek ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Porcine Model ◽  
Lymph Node Biopsy ◽  
Node Biopsy

scholarly journals Real-time in Situ Navigation System with Indocyanine Green Fluorescence for Sentinel Lymph Node Biopsy in Patients with Breast Cancer

2020 ◽  
Author(s):  
Zhaorui Wang ◽  
Xiaowei Yang ◽  
Peng Liu ◽  
Chunguang Han ◽  
Yubo Pan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Indocyanine Green ◽  
Real Time ◽  
Lymph Node Biopsy ◽  
Green Fluorescence ◽  
Indocyanine Green Fluorescence ◽  
Node Biopsy

Abstract Background: The naked-eye invisibility of indocyanine green fluorescence limits the application of near-infrared fluorescence imaging (NIR) systems for real-time navigation during sentinel lymph node biopsy (SLNB) in patients with breast cancer undergoing surgery. This study aims to evaluate the effectiveness and safety of a novel NIR system in visualizing indocyanine green fluorescence images in the surgical field and the application value of combined methylene blue (MB) and the novel NIR system in SLNB.Methods: Sixty patients with clinical node-negative breast cancer received indocyanine green (ICG) and MB as tracers. Two NIR system instruments, namely, lymphatic fluorescence imaging system (LFIS) designed by the University of Science and Technology of China and vascular imager by Langfang Mingde Medical Biotechnology Co., Ltd. (Langfang vascular imager), were used as navigation assistance to locate sentinel lymph nodes (SLNs). Excising the lymph nodes developed by both MB and ICG by two NIR systems or palpably suspicious as SLNs and undergoing rapid pathological examination.Results: Both instruments exhibited 95% (57/60) success for real-time lymphatic fluorescent images. A total of 186 SLNs were identified, of which two were pathologically confirmed as lacking any lymph node tissue. SLN identification rate was 100% (184/184) for MB plus LFIS and 86.96% (160/184) for MB alone. The median number of SLNs identified by LFIS combined with MB was 3 (range of 1–8), which was significantly higher than that by MB alone at 2 (range 1–7) (P<0.05).Conclusion: LFIS effectively detects SLNs in breast cancer, projects the fluorescence signals during surgery, and provides a continuous surgical navigation system without the need for a remote monitor. The ICG method navigated by combined LFIS and MB may be a promising alternative tracer for radioisotope in SLN mapping.

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