scholarly journals Phenotype of postural instability/gait difficulty in Parkinson disease: relevance to cognitive impairment and mechanism relating pathological proteins and neurotransmitters

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Li-Jun Zuo ◽  
Ying-Shan Piao ◽  
Li-Xia Li ◽  
Shu-Yang Yu ◽  
Peng Guo ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Parkinson Disease ◽  
Postural Instability ◽  
Postural Instability Gait Difficulty ◽  
Disease Relevance

scholarly journals Author Correction: Parkinson disease-associated cognitive impairment

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Dag Aarsland ◽  
Lucia Batzu ◽  
Glenda M. Halliday ◽  
Gert J. Geurtsen ◽  
Clive Ballard ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Parkinson Disease

scholarly journals Parkinson disease-associated cognitive impairment

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Dag Aarsland ◽  
Lucia Batzu ◽  
Glenda M. Halliday ◽  
Gert J. Geurtsen ◽  
Clive Ballard ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Parkinson Disease

scholarly journals White matter abnormalities in the corpus callosum with cognitive impairment in Parkinson disease

Neurology ◽  
2018 ◽  
Vol 91 (24) ◽  
pp. e2244-e2255 ◽  
Author(s):  
Ian O. Bledsoe ◽  
Glenn T. Stebbins ◽  
Doug Merkitch ◽  
Jennifer G. Goldman
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Corpus Callosum ◽  
Parkinson Disease ◽  
Information Transfer ◽  
Diffusion Tensor ◽  
Anterior Segment ◽  
Mean Diffusivity ◽  
Cognitive Domain ◽  
White Matter Abnormalities

ObjectiveTo evaluate microstructural characteristics of the corpus callosum using diffusion tensor imaging (DTI) and their relationships to cognitive impairment in Parkinson disease (PD).MethodsSeventy-five participants with PD and 24 healthy control (HC) participants underwent structural MRI brain scans including DTI sequences and clinical and neuropsychological evaluations. Using Movement Disorder Society criteria, PD participants were classified as having normal cognition (PD-NC, n = 23), mild cognitive impairment (PD-MCI, n = 35), or dementia (PDD, n = 17). Cognitive domain (attention/working memory, executive function, language, memory, visuospatial function) z scores were calculated. DTI scalar values, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD), were established for 5 callosal segments on a midsagittal plane, single slice using a topographically derived parcellation method. Scalar values were compared among participant groups. Regression analyses were performed on cognitive domain z scores and DTI metrics.ResultsParticipants with PD showed increased AD values in the anterior 3 callosal segments compared to healthy controls. Participants with PDD had significantly increased AD, MD, and RD in the anterior 2 segments compared to participants with PD-NC and most anterior segment compared to participants with PD-MCI. FA values did not differ significantly between participants with PD and participants with HC or among PD cognitive groups. The strongest associations for the DTI metrics and cognitive performance occurred in the most anterior and most posterior callosal segments, and also reflected fronto-striatal and posterior cortical type cognitive deficits, respectively.ConclusionsMicrostructural white matter abnormalities of the corpus callosum, as measured by DTI, may contribute to PD cognitive impairment by disrupting information transfer across interhemispheric and callosal–cortical projections.

scholarly journals Prevalence and Risk Factors of Cognitive Impairment in Parkinson Disease

Medicine ◽  
2015 ◽  
Vol 94 (17) ◽  
pp. e782 ◽  
Author(s):  
Yu-Ching Huang ◽  
Shwu-Tzy Wu ◽  
Juei-Jueng Lin ◽  
Che-Chen Lin ◽  
Chia-Hung Kao
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Parkinson Disease

scholarly journals Parkinson disease and cognitive impairment

2016 ◽  
Vol 6 (5) ◽  
pp. 452-458 ◽  
Author(s):  
Albert A. Davis ◽  
Brad Racette
Keyword(s):  
Cognitive Impairment ◽  
Parkinson Disease

A Randomized Trial of Oral and Transdermal Rivastigmine for Postural Instability in Parkinson Disease Dementia

2018 ◽  
Vol 41 (3) ◽  
pp. 87-93 ◽  
Author(s):  
Jaime McDonald ◽  
Emmanuelle Pourcher ◽  
Alexandra Nadeau ◽  
Philippe Corbeil
Keyword(s):  
Parkinson Disease ◽  
Randomized Trial ◽  
Postural Instability

COWAT Performance of Persons with Alzheimer Dementia, Vascular Dementia, and Parkinson Disease Dementia According to Stage of Cognitive Impairment

PM&R ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 737-744
Author(s):  
Kil‐Byung Lim ◽  
Jiyong Kim ◽  
Hong‐Jae Lee ◽  
Jeehyun Yoo ◽  
Ha Seong Kim ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Parkinson Disease ◽  
Vascular Dementia ◽  
Alzheimer Dementia
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