scholarly journals Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Emilie Andrio ◽  
Romain Lotte ◽  
Daniel Hamaoui ◽  
Jacqueline Cherfils ◽  
Anne Doye ◽  
...  
Keyword(s):  
Cell Growth ◽  
Growth Control ◽  
Missense Mutations ◽  
Cell Growth Control

scholarly journals A new twist on cell growth control

Cell Cycle ◽  
2014 ◽  
Vol 13 (22) ◽  
pp. 3474-3475 ◽  
Author(s):  
Joseph F Cardiello ◽  
Jennifer F Kugel ◽  
James A Goodrich
Keyword(s):  
Cell Growth ◽  
Growth Control ◽  
Cell Growth Control

Lysozyme-dependent Proliferation Switch: Hematopoietic and Hybridoma Cell Growth Control with the Use of Antibody/GP130 Chimera

2002 ◽  
pp. 337-341
Author(s):  
Masahiro Kawahara ◽  
Akito Natsume ◽  
Satoshi Terada ◽  
Koichi Kato ◽  
Kouhei Tsumoto ◽  
...  
Keyword(s):  
Cell Growth ◽  
Growth Control ◽  
Cell Growth Control

scholarly journals The bisecting GlcNAc in cell growth control and tumor progression

2012 ◽  
Vol 29 (8-9) ◽  
pp. 609-618 ◽  
Author(s):  
Hazuki E. Miwa ◽  
Yinghui Song ◽  
Richard Alvarez ◽  
Richard D. Cummings ◽  
Pamela Stanley
Keyword(s):  
Cell Growth ◽  
Tumor Progression ◽  
Growth Control ◽  
Cell Growth Control ◽  
Bisecting Glcnac

Abstract A055: A novel cell growth control pathway repressed by the oncogene TBX2 in breast cancer cells

2013 ◽  
Author(s):  
Zenobia Carmel D'Costa ◽  
Catherine A. Higgins ◽  
Richard Williams ◽  
Paul B. Mullan
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Growth Control ◽  
Cell Growth Control

Nulliparous CCAAT/Enhancer Binding Proteinδ (C/EBPδ) Knockout Mice Exhibit Mammary Gland Ductal Hyperlasia

2003 ◽  
Vol 228 (3) ◽  
pp. 278-285 ◽  
Author(s):  
Andrew P. Gigliotti ◽  
Peter F. Johnson ◽  
Esta Sterneck ◽  
James W. DeWille
Keyword(s):  
Mammary Gland ◽  
Cell Growth ◽  
Epithelial Cell ◽  
Mammary Epithelial Cell ◽  
Mammary Epithelial Cells ◽  
Growth Control ◽  
Mammary Epithelial ◽  
Estrus Cycle ◽  
The Mean ◽  
Cell Growth Control

CCAAT/Enhancer binding proteins (C/EBPs) are a family of nuclear proteins that function in the control of cell growth, death, and differentiation. We previously reported that C/EBPδ plays a key role in mammary epithelial cell G0 growth arrest. In this report, we investigated the role of C/EBPδ in mammary gland development and function using female mice homozygous for a targeted deletion of C/EBPδ (C/EBPδ –/–). C/EBPδ –/– females develop normally and exhibit normal reproductive and lactational performance. Adult nulliparous C/EBPδ –/– females, however, exhibit mammary epithelial cell growth control defects. The mean number of mammary ductal branches is significantly higher in adult nulliparous C/EBPδ –/– females compared with C/EBPδ +/+ (wild-type control) females (66.8 ± 5.2 vs 42.9 * 6.3 branch points/field, P < 0.01). In addition, the mean total mammary gland cellular volume occupied by epithelium is significantly higher in adult nulliparous C/EBPδ –/– females compared with C/EBPδ +/+ controls (29.0± 1.4 vs 20.4 ± 1.3, P < 0.001). Our results showed that the BrdU labeling index was significantly higher in mammary epithelial cells from nulliparous C/EBPδ –/– females compared with C/EBPδ +/+ controls during the proestrus/estrus (4.55 ± 0.70 vs 2.14 ± 0.43, P < 0.01) and metestrus/diestrus (6.92 ± 0.75 vs 3.98 ± 0.43 P < 0.01) phases of the estrus cycle. In contrast, the percentage of mammary epithelial cells undergoing apoptosis during both phases of the estrus cycle did not differ between C/EBPδ –/– and C/EBPδ +/+ females. The increased epithelial cell content and proliferative capacity was restricted to the nulliparous C/EBPδ –/– females as no differences in mammary gland morphology, ductal branching or total epithelial content were observed between multiparous C/EBPδ –/– and C/EBPδ +/+ females. These results demonstrate that C/EBPδ plays a novel role in mammary epithelial cell growth control that appears to be restricted to the nulliparous mammary gland.

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