scholarly journals To Find a Better Dosimetric Parameter in the Predicting of Radiation-Induced Lung Toxicity Individually: Ventilation, Perfusion or CT based

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Lin-Lin Xiao ◽  
Guoren Yang ◽  
Jinhu Chen ◽  
Xiaohui Wang ◽  
Qingwei Wu ◽  
...  
Keyword(s):  
Lung Toxicity ◽  
Dosimetric Parameter ◽  
Radiation Induced

scholarly journals OC-0085: Mitochondrial DNA variation as a biomarker for the development of radiation-induced lung toxicity

2015 ◽  
Vol 115 ◽  
pp. S43
Author(s):  
A. Voets ◽  
C. Oberije ◽  
G. Nalbantov ◽  
A.P. Stassen ◽  
A.T. Hendrickx ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Lung Toxicity ◽  
Dna Variation ◽  
Radiation Induced

scholarly journals Impact of radiation techniques on lung toxicity in patients with mediastinal Hodgkin’s lymphoma

2020 ◽  
Author(s):  
Niklas Benedikt Pepper ◽  
Michael Oertel ◽  
Christopher Kittel ◽  
Kai Jannes Kröger ◽  
Khaled Elsayad ◽  
...  
Keyword(s):  
Normal Tissue ◽  
Hodgkin’S Lymphoma ◽  
Radiation Pneumonitis ◽  
Organs At Risk ◽  
Normal Tissue Complication Probability ◽  
Lung Toxicity ◽  
Hodgkin's Lymphoma ◽  
Significant Difference ◽  
Radiation Induced ◽  
Increase In Risk

Abstract Purpose Mediastinal radiotherapy (RT), especially when combined with bleomycin, may result in substantial pulmonary morbidity and mortality. The use of modern RT techniques like intensity-modulated radiotherapy (IMRT) is gaining interest to spare organs at risk. Methods We evaluated 27 patients who underwent RT for Hodgkin’s lymphoma between 2009 and 2013 at our institution. For each patient, three different treatment plans for a 30-Gy involved-field RT (IFRT) were created (anterior-posterior-posterior-anterior setup [APPA], 5‑field IMRT, and 7‑field IMRT) and analyzed concerning their inherent “normal tissue complication probability” (NTCP) for pneumonitis and secondary pulmonary malignancy. Results The comparison of different radiation techniques showed a significant difference in favor of standard APPA (p < 0.01). The risk of lung toxicity was significantly higher in plans using 7‑field IMRT than in plans using 5‑field IMRT. The absolute juxtaposition showed an increase in risk for radiation pneumonitis of 1% for plans using 5‑field IMRT over APPA according to QUANTEC (Quantitative Analyses of Normal Tissue Effects in the Clinic) parameters (Burman: 0.15%) and 2.6% when using 7‑field IMRT over APPA (Burman: 0.7%) as well as 1.6% when using 7‑field IMRT over 5‑field IMRT (Burman: 0.6%). Further analysis showed an increase in risk for secondary pulmonary malignancies to be statistically significant (p < 0.01); mean induction probability for pulmonary malignoma was 0.1% higher in plans using 5‑field IMRT than APPA and 0.19% higher in plans using 7‑field IMRT than APPA as well as 0.09% higher in plans using 7‑field IMRT than 5‑field IMRT. During a median follow-up period of 65 months (95% confidence interval: 53.8–76.2 months), only one patient developed radiation-induced pneumonitis. No secondary pulmonary malignancies have been detected to date. Conclusion Radiation-induced lung toxicity is rare after treatment for Hodgkin lymphoma but may be influenced significantly by the RT technique used. In this study, APPA RT plans demonstrated a decrease in potential radiation pneumonitis and pulmonary malignancies. Biological planning using NTCP may have the potential to define personalized RT strategies

Sign in / Sign up

Export Citation Format

Share Document