scholarly journals Practical whole-tooth restoration utilizing autologous bioengineered tooth germ transplantation in a postnatal canine model

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Mitsuaki Ono ◽  
Masamitsu Oshima ◽  
Miho Ogawa ◽  
Wataru Sonoyama ◽  
Emilio Satoshi Hara ◽  
...  
Keyword(s):  
Tooth Germ ◽  
Canine Model ◽  
Bioengineered Tooth

scholarly journals Whole Tooth Regenerative Therapy Using a Bioengineered Tooth Germ

2013 ◽  
Vol 1 (1) ◽  
pp. 43-49
Author(s):  
Kei Nakajima ◽  
Masamitsu Oshima ◽  
Takashi Tsuji
Keyword(s):  
Tooth Germ ◽  
Regenerative Therapy ◽  
Bioengineered Tooth

V1540: Potassium-Titanyl-Phosphate (KTP) Laser Nerve-Sparing Laparoscopic Radical Prostatectomy: Effects on Cavernous Nerve Function in a Canine Model

2007 ◽  
Vol 177 (4S) ◽  
pp. 508-509
Author(s):  
Troy R. Gianduzzo ◽  
Jose R. Colombo ◽  
Georges-Pascal Haber ◽  
Kester Nahen ◽  
Cristina Magi-Galluzzi ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Canine Model ◽  
Laparoscopic Radical Prostatectomy ◽  
Potassium Titanyl Phosphate ◽  
Nerve Sparing ◽  
Ktp Laser ◽  
Nerve Function ◽  
Cavernous Nerve

1412: Corporal Cavernosal Apoptosis Following Radical Prostatectomy in the Canine Model

2004 ◽  
Vol 171 (4S) ◽  
pp. 372-372
Author(s):  
Carlumandarlo E.B. Zaramo ◽  
Nina G. Hall ◽  
Rupesh Raina ◽  
Ashok Agarwal ◽  
Inderbir S. Gill ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Canine Model

Autoradiography of Incorporated Leucine-H3 in the Enamel Matrix and Enamel Organ of the Upper Incisor of the Rat

1964 ◽  
Vol 04 (02) ◽  
pp. 186-192
Author(s):  
Leonel Costacurta
Keyword(s):  
Amino Acid ◽  
Blood Vessels ◽  
Tooth Germ ◽  
Longitudinal Section ◽  
Equal Length ◽  
Enamel Organ ◽  
Enamel Matrix ◽  
Distal Extremity ◽  
Old Rats ◽  
Thin Band

SummaryDental germs of the upper incisors of six-days old rats were studied for the uptake of leucine-H3 by different layers of the enamel organ in correlation to the various stages of the development of enamel.The longitudinal section of the tooth germ was divided into 15 zones of about equal length in order to facilitate the description and interpretation of results. Autoradiographic images of the histologic preparations from rats sacrificed 30 minutes, 1 hour, 1 day and 3 days after the injection were made. The strongest reactions were observed in dental germs of rats sacrificed 1 hour, and particularly one day, after the leucine-H3 injection.The uptake of this compound by the enamel matrix increases progressively up to the young enamel and then decreases to the distal extremity; the greatest quantity of this labeled amino-acid was observed in the primary and young enamel. The reactions were present in the transitional enamel only along a thin band close to the dentine-enamel junction.In the enamel organ leucine-H3 incorporation was greatest in the three layers, the zones corresponding to primary and young enamel. In zones corresponding to transitional enamel, the inner epithelium showed a small quantity, and the stellate reticulum a blackening only in its superficial part, were the blood vessels reach the enamel organ.

Comparison of High Purity Factor IX Concentrates and a Prothrombin Complex Concentrate in a Canine Model of Thrombogenicity

1991 ◽  
Vol 66 (05) ◽  
pp. 609-613 ◽  
Author(s):  
I R MacGregor ◽  
J M Ferguson ◽  
L F McLaughlin ◽  
T Burnouf ◽  
C V Prowse
Keyword(s):  
High Purity ◽  
Time Course ◽  
Prothrombin Complex Concentrate ◽  
Degradation Products ◽  
Canine Model ◽  
Factor Ix ◽  
In Vitro Tests ◽  
Albumin Infusion

SummaryA non-stasis canine model of thrombogenicity has been used to evaluate batches of high purity factor IX concentrates from 4 manufacturers and a conventional prothrombin complex concentrate (PCC). Platelets, activated partial thromboplastin time (APTT), fibrinogen, fibrin(ogen) degradation products and fibrinopeptide A (FPA) were monitored before and after infusion of concentrate. Changes in FPA were found to be the most sensitive and reproducible indicator of thrombogenicity after infusion of batches of the PCC at doses of between 60 and 180 IU/kg, with a dose related delayed increase in FPA occurring. Total FPA generated after 100-120 IU/kg of 3 batches of PCC over the 3 h time course was 9-12 times that generated after albumin infusion. In contrast the amounts of FPA generated after 200 IU/kg of the 4 high purity factor IX products were in all cases similar to albumin infusion. It was noted that some batches of high purity concentrates had short NAPTTs indicating that current in vitro tests for potential thrombogenicity may be misleading in predicting the effects of these concentrates in vivo.

The Development of Homologous (Canine/Anti-Canine) Antibodies in Dogs with Haemophilia A (Factor VIII Deficiency): A Ten-Year Longitudinal Study

1993 ◽  
Vol 69 (01) ◽  
pp. 021-024 ◽  
Author(s):  
Shawn Tinlin ◽  
Sandra Webster ◽  
Alan R Giles
Keyword(s):  
Factor Viii ◽  
Canine Model ◽  
Significant Inhibition ◽  
Human Condition ◽  
Haemophilia A ◽  
Variable Expression ◽  
The Family ◽  
Over Time

SummaryThe development of inhibitors to factor VIII in patients with haemophilia A remains as a serious complication of replacement therapy. An apparently analogous condition has been described in a canine model of haemophilia A (Giles et al., Blood 1984; 63:451). These animals and their relatives have now been followed for 10 years. The observation that the propensity for inhibitor development was not related to the ancestral factor VIII gene has been confirmed by the demonstration of vertical transmission through three generations of the segment of the family related to a normal (non-carrier) female that was introduced for breeding purposes. Haemophilic animals unrelated to this animal have not developed functionally significant factor VIII inhibitors despite intensive factor VIII replacement. Two animals have shown occasional laboratory evidence of factor VIII inhibition but this has not been translated into clinical significant inhibition in vivo as assessed by clinical response and F.VIII recovery and survival characteristics. Substantial heterogeneity of inhibitor expression both in vitro and in vivo has been observed between animals and in individual animals over time. Spontaneous loss of inhibitors has been observed without any therapies designed to induce tolerance, etc., being instituted. There is also phenotypic evidence of polyclonality of the immune response with variable expression over time in a given animal. These observations may have relevance to the human condition both in determining the pathogenetic factors involved in this condition and in highlighting the heterogeneity of its expression which suggests the need for caution in the interpretation of the outcome of interventions designed to modulate inhibitor activity.

Mitral Annular Remodeling to Treat Functional Mitral Regurgitation: A Pilot Acute Study in a Canine Model

2010 ◽  
Vol 13 (4) ◽  
pp. E247-E250 ◽  
Author(s):  
Hideyuki Fumoto ◽  
Tohru Takaseya ◽  
Akira Shiose ◽  
Roberto M. Saraiva ◽  
Yoko Arakawa ◽  
...  
Keyword(s):  
Mitral Regurgitation ◽  
Canine Model ◽  
Functional Mitral Regurgitation ◽  
Acute Study
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