scholarly journals Acid phosphatase 2 (ACP2) is required for membrane fusion during influenza virus entry

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jihye Lee ◽  
Jinhee Kim ◽  
Kidong Son ◽  
Anne-Laure Pham Humg d’Alexandry d’Orengiani ◽  
Ji-Young Min
Keyword(s):  
Influenza Virus ◽  
Acid Phosphatase ◽  
Membrane Fusion ◽  
Virus Entry

scholarly journals Small Molecule Inhibitors of Influenza Virus Entry

2021 ◽  
Vol 14 (6) ◽  
pp. 587
Author(s):  
Zhaoyu Chen ◽  
Qinghua Cui ◽  
Michael Caffrey ◽  
Lijun Rong ◽  
Ruikun Du
Keyword(s):  
Influenza Virus ◽  
Membrane Fusion ◽  
Small Molecule ◽  
Drug Target ◽  
Small Molecule Inhibitors ◽  
Virus Entry ◽  
Critical Role ◽  
Structural Basis ◽  
Future Directions ◽  
The Past

Hemagglutinin (HA) plays a critical role during influenza virus receptor binding and subsequent membrane fusion process, thus HA has become a promising drug target. For the past several decades, we and other researchers have discovered a series of HA inhibitors mainly targeting its fusion machinery. In this review, we summarize the advances in HA-targeted development of small molecule inhibitors. Moreover, we discuss the structural basis and mode of action of these inhibitors, and speculate upon future directions toward more potent inhibitors of membrane fusion and potential anti-influenza drugs.

scholarly journals Synthesis of Four Pentacyclic Triterpene–Sialylglycopeptide Conjugates and Their Affinity Assays with Hemagglutinin

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 895
Author(s):  
Mei Luo ◽  
Ximin Wu ◽  
Yiming Li ◽  
Fujiang Guo
Keyword(s):  
Influenza Virus ◽  
Virus Entry ◽  
Cycloaddition Reaction ◽  
Pentacyclic Triterpene ◽  
Entry Inhibitors ◽  
Important Target ◽  
Virus Entry Inhibitors ◽  
Influenza Outbreaks ◽  
Ha Protein ◽  
Dissociation Constant Kd

Influenza outbreaks pose a serious threat to human health. Hemagglutinin (HA) is an important target for influenza virus entry inhibitors. In this study, we synthesized four pentacyclic triterpene conjugates with a sialylglycopeptide scaffold through the Cu(I)-catalyzed alkyne-azide cycloaddition reaction (CuAAC) and prepared affinity assays of these conjugates with two HAs, namely H1N1 (A/WSN/1933) and H5N1 (A/Hong Kong/483/97), respectively. With a dissociation constant (KD) of 6.89 μM, SCT-Asn-betulinic acid exhibited the strongest affinity with the H1N1 protein. Furthermore, with a KD value of 9.10 μM, SCT-Asn-oleanolic acid exhibited the strongest affinity with the H5N1 protein. The conjugates considerably enhanced antiviral activity, which indicates that pentacyclic triterpenes can be used as a ligand to improve the anti-influenza ability of the sialylglycopeptide molecule by acting on the HA protein.

scholarly journals Treatment of influenza virus with Beta-propiolactone alters viral membrane fusion

2014 ◽  
Vol 1838 (1) ◽  
pp. 355-363 ◽  
Author(s):  
Pierre Bonnafous ◽  
Marie-Claire Nicolaï ◽  
Jean-Christophe Taveau ◽  
Michel Chevalier ◽  
Fabienne Barrière ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Membrane Fusion ◽  
Viral Membrane ◽  
Viral Membrane Fusion

Design, synthesis and biological activity evaluation of novel conjugated sialic acid and pentacyclic triterpene derivatives as anti-influenza entry inhibitors

MedChemComm ◽  
2016 ◽  
Vol 7 (10) ◽  
pp. 1932-1945 ◽  
Author(s):  
Xu Han ◽  
Yongying Shi ◽  
Longlong Si ◽  
Zibo Fan ◽  
Han Wang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Biological Activity ◽  
Sialic Acid ◽  
Virus Entry ◽  
Pentacyclic Triterpene ◽  
Design Synthesis ◽  
Entry Inhibitors ◽  
Activity Evaluation ◽  
Virus Entry Inhibitors

A total of 24 novel sialic acid–pentacyclic triterpene conjugates were synthesized and evaluated as anti-influenza virus entry inhibitors.

scholarly journals Studies on the Structure of the Influenza Virus Haemagglutinin at the pH of Membrane Fusion

1988 ◽  
Vol 69 (11) ◽  
pp. 2785-2795 ◽  
Author(s):  
R. W. H. Ruigrok ◽  
A. Aitken ◽  
L. J. Calder ◽  
S. R. Martin ◽  
J. J. Skehel ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Membrane Fusion ◽  
Influenza Virus Haemagglutinin ◽  
Virus Haemagglutinin

Design and Synthesis of Oleanolic Acid Trimers to Enhance Inhibition of Influenza Virus Entry

2021 ◽  
Author(s):  
Liang Shao ◽  
Fan Yang ◽  
Yangqing Su ◽  
Weijia Li ◽  
Jihong Zhang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Oleanolic Acid ◽  
Virus Entry ◽  
Design And Synthesis
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