scholarly journals Accuracy and safety verification of ovarian reserve assessment technique for ovarian tissue transplantation using optical coherence tomography in mice ovary

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Seido Takae ◽  
Kosuke Tsukada ◽  
Yorino Sato ◽  
Naoki Okamoto ◽  
Tai Kawahara ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Ovarian Reserve ◽  
Ovarian Tissue ◽  
Tissue Transplantation ◽  
Optical Coherence ◽  
Safety Verification ◽  
Ovarian Tissue Transplantation ◽  
Assessment Technique

Ovarian tissue transplantation

2011 ◽  
pp. 357-366 ◽  
Author(s):  
Jacques Donnez ◽  
Jean Squifflet ◽  
Marie-Madeleine Dolmans
Keyword(s):  
Ovarian Tissue ◽  
Tissue Transplantation ◽  
Ovarian Tissue Transplantation

Livebirth after cryopreserved ovarian tissue transplantation – Authors' reply

The Lancet ◽  
2012 ◽  
Vol 380 (9837) ◽  
pp. 107
Author(s):  
J Donnez ◽  
MM Dolmans ◽  
D Demylle ◽  
P Jadoul ◽  
C Pirard ◽  
...  
Keyword(s):  
Ovarian Tissue ◽  
Tissue Transplantation ◽  
Ovarian Tissue Transplantation ◽  
Cryopreserved Ovarian Tissue

scholarly journals Is Ovarian Tissue Transplantation Safe in Patients with Central Nervous System Primitive Neuroectodermal Tumors?

2020 ◽  
Vol 9 (12) ◽  
pp. 4101
Author(s):  
Thu Yen Thi Nguyen ◽  
Alessandra Camboni ◽  
Rossella Masciangelo ◽  
Jacques Donnez ◽  
Marie-Madeleine Dolmans
Keyword(s):  
Cancer Cells ◽  
Ovarian Tissue ◽  
Neuron Specific Enolase ◽  
Cancer Recurrence ◽  
Tissue Transplantation ◽  
Ovarian Tissue Transplantation ◽  
Primitive Neuroectodermal Tumors ◽  
Immunodeficient Mice ◽  
Neuroectodermal Tumors ◽  
Digital Polymerase Chain Reaction

The risk of reseeding malignancy harbored in cryopreserved and transplanted ovarian tissue has been a source of concern. This study aimed to determine the potential relationship between frozen–thawed ovarian tissue transplantation and primary cancer recurrence. Three patients with cerebral primitive neuroectodermal tumors (PNET) were included in this study. One woman gave birth to three healthy babies following reimplantation of her cryopreserved ovarian tissue, but subsequently died due to cancer relapse six years after ovarian tissue transplantation. The second subject died from progressive cancer, while the third is still alive and awaiting reimplantation of her ovarian tissue in due course. Frozen ovarian cortex from all three patients was analyzed and xenotransplanted to immunodeficient mice for five months. Main outcomes were the presence of cancer cells in the thawed and xenografted ovarian tissue at histology, immunostaining (expression of neuron-specific enolase and glial fibrillary acidic protein (GFAP)), and reverse-transcription droplet digital polymerase chain reaction (RT-ddPCR) (levels of enolase 2 and GFAP). In conclusion, no malignant cells were detected in ovarian tissue from patients with PNET, even in those who experienced recurrence of the disease, meaning that the risk of reseeding cancer cells with ovarian tissue transplantation in these patients can be considered low.

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