scholarly journals Antitumorigenic effect of atmospheric-pressure dielectric barrier discharge on human colorectal cancer cells via regulation of Sp1 transcription factor

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Duksun Han ◽  
Jin Hyoung Cho ◽  
Ra Ham Lee ◽  
Woong Bang ◽  
Kyungho Park ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Transcription Factor ◽  
Atmospheric Pressure ◽  
Barrier Discharge ◽  
Human Colorectal Cancer ◽  
Dielectric Barrier ◽  
Sp1 Transcription Factor ◽  
Colorectal Cancer Cells ◽  
Antitumorigenic Effect ◽  
Human Colorectal Cancer Cells

scholarly journals Visfatin and Resveratrol Differentially Regulate the Expression of Thymidylate Synthase to Control the Sensitivity of Human Colorectal Cancer Cells to Capecitabine Cytotoxicity

Life ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1371
Author(s):  
Kuen-Lin Wu ◽  
Ko-Chao Lee ◽  
Chia-Kuang Yen ◽  
Cheng-Nan Chen ◽  
Shun-Fu Chang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Thymidylate Synthase ◽  
Human Colorectal Cancer ◽  
First Line ◽  
Sp1 Transcription Factor ◽  
Potential Capacity ◽  
Colorectal Cancer Cells ◽  
Line Drug ◽  
Human Colorectal Cancer Cells ◽  
Natural Component

Colorectal cancer (CRC) is a highly lethal malignant cancer. Capecitabine, a 5-fluororacil (5-FU) derivate, is its first-line drug, but the resistance of CRC to capecitabine is still the most challenging factor for curing patients. It has been suggested that thymidylate synthase (TYMS) level might affect the capecitabine efficacy in CRC patients, but the mechanism still needs more elucidation. Obesity is a risk factor for CRC. Recently, a correlation between serum visfatin, an obesity-elicited adipokine, and CRC development has been found. Thus, the aim of present study is to examine the visfatin capacity in TYMS expression and in the development of capecitabine resistance of CRC. Moreover, an attractive natural component, i.e., resveratrol, has been proposed in anticancer therapy and has hence been examined in the present study to see its potential capacity in the alleviation of CRC resistance. Our results found that visfatin significantly reduces the CRC sensitivity to capecitabine by controlling the TYMS expression via p38 signaling and Sp1 transcription factor. Moreover, resveratrol could significantly alleviate the visfatin effect on capecitabine-treated CRC cells. These results provided new insights to understand the capecitabine susceptibility of CRC under a visfatin-containing environment and a possible therapeutic application of resveratrol in CRC patients with obesity.

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