scholarly journals Erratum: Corrigendum: Long intergenic non-coding RNA 271 is predictive of a poorer prognosis of papillary thyroid cancer

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Ben Ma ◽  
Tian Liao ◽  
Duo Wen ◽  
Chuanpeng Dong ◽  
Li Zhou ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Non Coding Rna

Long non‐coding RNA TTN‐AS1 facilitates tumorigenesis of papillary thyroid cancer through modulating the miR‐153‐3p/ZNRF2 axis

2019 ◽  
Vol 21 (5) ◽  
pp. e3083 ◽  
Author(s):  
Zhenghui Cui ◽  
Zhiyan Luo ◽  
Zimei Lin ◽  
Liuhong Shi ◽  
Yurong Hong ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Abstract 3570: Investigating coding and non-coding RNA in papillary thyroid cancer

2019 ◽  
Author(s):  
Sina Dadafarin ◽  
Anvita Gupta ◽  
Katharine Dermigny ◽  
Leyla Cavdar ◽  
Brandon Pecchia ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Non Coding Rna

scholarly journals The NEAT1_2/miR-491 Axis Modulates Papillary Thyroid Cancer Invasion and Metastasis Through TGM2/NFκb/FN1 Signaling

2021 ◽  
Vol 11 ◽  
Author(s):  
Wei Sun ◽  
Yuan Qin ◽  
Zhihong Wang ◽  
Wenwu Dong ◽  
Liang He ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Nuclear Translocation ◽  
Transglutaminase 2 ◽  
Luciferase Reporter ◽  
Papillary Thyroid ◽  
Invasion And Metastasis ◽  
Non Coding Rna ◽  
Reporter Assays ◽  
Functional Analyses

NEAT1 (nuclear paraspeckle assembly transcript 1) is an oncogenic long non-coding RNA (lncRNA) that facilitates tumorigenesis in multiple cancers. In papillary thyroid cancer (PTC), the molecular mechanism by which NEAT1 affects invasion and metastasis remains elusive. RNA sequencing was used to discover differentially expressed NEAT1_2 downstream genes. Protein and RNA expression analyses and immunohistochemistry detected the expression of NEAT1_2, Transglutaminase 2 (TGM2), and microRNA-491 (miR-491) among PTC and non-cancerous tissues. Transwell and wound healing assays, and a mouse model of lung metastasis were used for further functional analyses. Bioinformatics was performed to predict miRNAs binding to both NEAT1_2 and TGM2. Rescue experiments and dual-luciferase reporter assays were performed. In PTC tissues, NEAT1_2 expression was markedly increased and regulated TGM2 expression. TGM2 was overexpressed in PTC, correlating positively with exthyroidal extension and lymph node metastasis. TGM2 knockdown significantly inhibited invasion and metastasis. NEAT1_2 sponged miR-491, acting as a competing endogenous RNA to regulate TGM2 expression. Fibronectin 1 (FN1) was predicted as a TGM2 target. TGM2 could transcriptionally activate FN1 by promoting nuclear factor kappa B (NFκb) p65 nuclear translocation, ultimately promoting PTC invasion/metastasis. These findings identify that NEAT1_2 sponges miR-491 to regulate TGM2 expression. TGM2 activates FN1 via NFκb to promote PTC invasion and metastasis.

scholarly journals Increased Expression of hsa_circ_0002111 and Its Clinical Significance in Papillary Thyroid Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Gongbo Du ◽  
Runsheng Ma ◽  
Hongqiang Li ◽  
Jiao He ◽  
Kaixiang Feng ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Cell Function ◽  
Characteristic Curve ◽  
Circular Rna ◽  
Cell Counting ◽  
Migration And Invasion ◽  
Papillary Thyroid ◽  
Non Coding Rna

Circular RNA (circRNA) is a newly discovered non-coding RNA. Recent reports suggest that circRNAs are key regulators of tumorigenesis because of their special structure. In order to investigate the role of hsa_circ_0002111 in papillary thyroid cancer (PTC), we use quantitative real-time polymerase chain reaction (qRT-PCR) to determine the expression pattern of hsa_circ_0002111 in 82 paired PTC and adjacent non-cancerous thyroid tissues. Cell counting kit-8, colony formation, and transwell assays were conducted to assess the effect of hsa_circ_0002111 on PTC cell proliferation, migration, and invasion. We found that the expression of hsa_circ_0002111 was significantly up-regulated in PTC tissues compared with adjacent non-cancerous tissues (P < 0.0001). Expression of hsa_circ_0002111 was also associated with advanced TNM stage and lymph-node metastasis of patients with PTC. The area under the receiver operating characteristic curve was 0.833. Further, cell function assays showed that hsa_circ_0002111 inhibition significantly suppressed the proliferation and invasion abilities of PTC cells in vitro. In conclusions, the study findings show that the over-expression of hsa_circ_0002111 promotes PTC, and thus hsa_circ_0002111 may be a potential diagnostic biomarker and therapeutic target for PTC.

scholarly journals Identification of novel long non-coding RNA biomarkers for prognosis prediction of papillary thyroid cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (28) ◽  
pp. 46136-46144 ◽  
Author(s):  
Qiuying Li ◽  
Haihong Li ◽  
Lu Zhang ◽  
Chunming Zhang ◽  
Wentao Yan ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Prognosis Prediction ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Rna Biomarkers

scholarly journals Long non-coding RNA AGAP2-AS1 increases the invasiveness of papillary thyroid cancer

Aging ◽  
2020 ◽  
Vol 12 (18) ◽  
pp. 18019-18032
Author(s):  
Liang Shao ◽  
Wei Sun ◽  
Hao Zhang ◽  
Ping Zhang ◽  
Zhihong Wang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Non Coding Rna ◽  
Long Non Coding Rna
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