scholarly journals Impact of Dehydroepiandrosterone Sulfate on Newborn Leukocyte Telomere Length

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Han Liu ◽  
Guangdi Zhou ◽  
Qian Chen ◽  
Fengxiu Ouyang ◽  
Julian Little ◽  
...  
Keyword(s):  
Telomere Length ◽  
Dehydroepiandrosterone Sulfate ◽  
Leukocyte Telomere Length

scholarly journals Leukocyte Telomere Length and Serum Levels of High-Molecular-Weight Adiponectin and Dehydroepiandrosterone-Sulfate Could Reflect Distinct Aspects of Longevity in Japanese Centenarians

2017 ◽  
Vol 3 ◽  
pp. 233372141769667
Author(s):  
Yuji Aoki ◽  
Masato Aoki ◽  
Kazuya Yamada
Keyword(s):  
Molecular Weight ◽  
Telomere Length ◽  
High Molecular Weight ◽  
Performance Status ◽  
Serum Levels ◽  
Dehydroepiandrosterone Sulfate ◽  
Leukocyte Telomere Length ◽  
Protection Assay ◽  
High Molecular Weight Adiponectin ◽  
And Performance

Leukocyte telomere length and serum levels of high-molecular-weight adiponectin and dehydroepiandrosterone-sulfate (DHEA-S) were assessed in association with nutrition and performance status (PS) in Japanese centenarians. Twenty-three centenarians (five men, 18 women) were classified according to their PS 1 (nearly fully ambulatory, n = 2), 2 (in bed less than 50% of daytime, n = 10), 3 (in bed greater than 50%, n = 6), and 4 (completely bedridden, n = 5). Leukocyte telomere length was determined by the hybridization protection assay, and the adiponectin and DHEA-S levels were measured by chemiluminescent enzyme immunoassay. Among variables of PS, body mass index (BMI), albumin, adiponectin, DHEA-S, and telomere length, there were significant correlations between PS and albumin ( r = −.694, p < .01), between telomere length and BMI ( r = .522, p < .05), between adiponectin and BMI ( r = −.574, p < .01), and between DHEA-S and albumin ( r = .530, p < .01). When excluding two cancer-bearing centenarians with short telomere, telomere length significantly correlated with PS ( r = −.632, p < .01). It was indicated that the short leukocyte telomere was associated with poor PS and cancer development and that the adiponectin or DHEA-S was associated with adiposity or nutritional status. Despite a small number of subjects, these biomarkers seemed to reflect distinct aspects of longevity in Japanese centenarians.

scholarly journals Association of leukocyte telomere length with chronic kidney disease in East Asians with type 2 diabetes: A Mendelian randomization study

2021 ◽  
Author(s):  
Resham L Gurung ◽  
Rajkumar Dorajoo ◽  
Yiamunaa M ◽  
Ling Wang ◽  
Sylvia Liu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Telomere Length ◽  
Mendelian Randomization ◽  
Random Effect ◽  
Leukocyte Telomere Length ◽  
Increased Risk ◽  
Genetically Determined

Abstract Background Chronic kidney disease (CKD) is common among type 2 diabetes (T2D) and increases the risk of kidney failure and cardiovascular diseases. Shorter leukocyte telomere length is associated with CKD in patients with T2D. We previously reported single nucleotide polymorphisms (SNPs) associated with leukocyte telomere length in Asian population. In this study, we elucidated the association of these SNPs with CKD in patients with T2D using Mendelian randomization (MR) approach. Methods The cross-sectional association of 16 leukocyte telomere length SNPs with CKD, defined as an estimated glomerular filtration rate of less than 60 ml/min/1.73m2 was assessed among 4,768 (1,628 cases, 3,140 controls) participants in the Singapore Study of Macro-angiopathy and Micro-vascular Reactivity in Type 2 Diabetes and Diabetic Nephropathy cohorts. MR analysis was performed using the random-effect inverse-variance weighted (IVW) method, the weighted median, MR-Egger and Radial MR adjusted for age and sex-stratified by cohorts and ethnicity (Chinese and Malays), then meta-analysed. Results Genetically determined shorter leukocyte telomere length was associated with increased risk of CKD in patients with T2D (meta-IVW adjusted odds ratio = 1.51 [95% confidence interval, 1.12 - 2.12; P = 0.007; Phet= 0.547]). Similar results were obtained following sensitivity analysis. MR-Egger analysis (intercept) suggested no evidence of horizontal pleiotropy (β  =  0.010, P = 0.751). Conclusions Our findings suggest that genetically determined leukocyte telomere length is associated with CKD in patients with T2D. Further studies are warranted to elucidate the causal role of telomere length in CKD progression.

scholarly journals Association between leukocyte telomere length and sex by quantile regression analysis

2021 ◽  
Author(s):  
Fernanda Gutierrez-Rodrigues ◽  
Raquel M. Alves-Paiva ◽  
Natália F. Scatena ◽  
Edson Z. Martinez ◽  
Priscila S. Scheucher ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Quantile Regression ◽  
Telomere Length ◽  
Leukocyte Telomere Length ◽  
Quantile Regression Analysis

Leukocyte telomere length: a potential biomarker for the prognosis of coronary artery disease

2020 ◽  
Vol 14 (11) ◽  
pp. 933-941
Author(s):  
Ying Sun ◽  
Wei Wang ◽  
Yue-Ru Jiao ◽  
Jian Ren ◽  
Lei Gao ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Telomere Length ◽  
Healthy Subjects ◽  
Independent Predictor ◽  
Cox Proportional Hazards ◽  
Leukocyte Telomere Length ◽  
Cardiac Events ◽  
Potential Biomarker ◽  
Artery Disease

Aim: This study aimed to explore the prognostic value of leukocyte telomere length (LTL) in patients with coronary artery disease (CAD). Materials & methods: We enrolled 366 CAD patients and 76 healthy subjects in this study. LTL was measured. All subjects were followed up for 6 months for further analysis regarding major adverse cardiac events (MACEs). Results: CAD patients had a significantly shortened LTL compared with healthy subjects (p < 0.05). The area under the curve for LTL prediction of MACEs was 0.769 (p < 0.001), with a shorter LTL being an independent predictor of MACEs (Cox proportional hazards regression, hazard ratio: 2.866; p < 0.001). Conclusion: LTL could be considered as an independent predictor of short-term MACEs in CAD.

Association between leukocyte telomere length and bone mineral density in women 25–93years of age

2015 ◽  
Vol 66 ◽  
pp. 25-31 ◽  
Author(s):  
Barbara Rubek Nielsen ◽  
Allan Linneberg ◽  
Laila Bendix ◽  
Maria Harboe ◽  
Kaare Christensen ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Telomere Length ◽  
Bone Mineral ◽  
Leukocyte Telomere Length ◽  
Mineral Density
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