scholarly journals Bis(3,5-diiodo-2,4,6-trihydroxyphenyl)squaraine photodynamic therapy disrupts redox homeostasis and induce mitochondria-mediated apoptosis in human breast cancer cells

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
P. S. Saneesh Babu ◽  
Prasad M. Manu ◽  
T. Jayaram Dhanya ◽  
Pradhan Tapas ◽  
R. Nair Meera ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Redox Homeostasis ◽  
Human Breast Cancer Cells ◽  
Human Breast

scholarly journals Photodynamic effect of Zirconium phosphate biocompatible nano-bilayers containing methylene blue on cancer and normal cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Reza Hosseinzadeh ◽  
Khatereh Khorsandi
Keyword(s):  
Breast Cancer ◽  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Zirconium Phosphate ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Therapy Efficacy

Abstract Pharmaceutical applications of methylene blue, especially as photosensitizer, have been limited due to its rapid enzymatic reduction in the biological systems. In this study nano-platelet zirconium phosphate was synthesized and its biocompatibility was evaluated. The synthesized material was considered as drug delivery vehicle for methylene blue to enhance the photodynamic therapy efficacy in human breast cancer cells. Zirconium phosphate-methylene blue nano-hybrids were characterized by X-Ray Powder Diffraction (XRPD), Scanning Electron Microscopy (SEM), and Thermo gravimetric Analysis (TGA). Biocompatibility of synthesized nano materials were studied on Hu02 human fibroblast normal cell and MDA-MB-231 human breast cancer cell. The results clarified that ZrP-MB nanoparticles could decrease the dark toxicity of free methylene blue. Photodynamic therapy using zirconium phosphate-methylene blue on MDA-MB-231 human breast cancer was evaluated by MTT assay, colony forming ability assay, AO/EB dual staining and flow cytometry detection of apoptosis. The results suggest that zirconium phosphate-methylene blue nano-hybrids significantly enhance photodynamic therapy efficacy probably via apoptosis cell death mechanism against human breast cancer cells. According to the results, zirconium phosphate nanoparticles could be suggested as a promising nano-carrier for photosensitizer delivery in photodynamic therapy.

scholarly journals Photodynamic therapy with the dual-mode association of IR780 to PEG-PLA nanocapsules and the effects on human breast cancer cells

2022 ◽  
Vol 145 ◽  
pp. 112464
Author(s):  
Marina Guimarães Carvalho Machado ◽  
Maria Alice de Oliveira ◽  
Elisa Gomes Lanna ◽  
Raoni Pais Siqueira ◽  
Gwenaelle Pound-Lana ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Dual Mode

Curcumin intercalated layered double hydroxide nanohybrid as a potential drug delivery system for effective photodynamic therapy in human breast cancer cells

RSC Advances ◽  
2015 ◽  
Vol 5 (114) ◽  
pp. 93987-93994 ◽  
Author(s):  
Khatereh Khorsandi ◽  
Reza Hosseinzadeh ◽  
Mohsen Fateh
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Potential Drug ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Double Hydroxide

Curcumin intercalated layered double hydroxide nanohybrid as a potential drug delivery system has been used for effective photodynamic therapy (PDT) in human breast cancer cells.

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