scholarly journals BMP2-coprecipitated calcium phosphate granules enhance osteoinductivity of deproteinized bovine bone, and bone formation during critical-sized bone defect healing

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Tie Liu ◽  
Yuanna Zheng ◽  
Gang Wu ◽  
Daniel Wismeijer ◽  
Janak L. Pathak ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Bone Defect ◽  
Bovine Bone ◽  
Defect Healing ◽  
Bone Defect Healing ◽  
Deproteinized Bovine Bone

Design and Fabrication of Complex Scaffolds for Bone Defect Healing: Combined 3D Plotting of a Calcium Phosphate Cement and a Growth Factor-Loaded Hydrogel

2016 ◽  
Vol 45 (1) ◽  
pp. 224-236 ◽  
Author(s):  
Tilman Ahlfeld ◽  
Ashwini Rahul Akkineni ◽  
Yvonne Förster ◽  
Tino Köhler ◽  
Sven Knaack ◽  
...  
Keyword(s):  
Growth Factor ◽  
Calcium Phosphate ◽  
Bone Defect ◽  
Calcium Phosphate Cement ◽  
Defect Healing ◽  
Bone Defect Healing

scholarly journals Critical Size Bone Defect Healing Using Collagen–Calcium Phosphate Bone Graft Materials

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0168883 ◽  
Author(s):  
William Robert Walsh ◽  
Rema A. Oliver ◽  
Chris Christou ◽  
Vedran Lovric ◽  
Emma Rose Walsh ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Graft ◽  
Bone Defect ◽  
Critical Size ◽  
Defect Healing ◽  
Bone Defect Healing

scholarly journals Role of osteogenic Dickkopf-1 in bone remodeling and bone healing in mice with type I diabetes mellitus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nick Hildebrandt ◽  
Juliane Colditz ◽  
Caio Dutra ◽  
Paula Goes ◽  
Juliane Salbach-Hirsch ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Formation ◽  
Bone Defect ◽  
Serum Levels ◽  
Diabetic Control ◽  
Male Mice ◽  
Defect Healing ◽  
Bone Defect Healing ◽  
Dickkopf 1

AbstractType 1 diabetes mellitus (T1DM) is associated with low bone mass and a higher risk for fractures. Dickkopf-1 (Dkk1), which inhibits Wnt signaling, osteoblast function, and bone formation, has been found to be increased in the serum of patients with T1DM. Here, we investigated the functional role of Dkk1 in T1DM-induced bone loss in mice. T1DM was induced in 10-week-old male mice with Dkk1-deficiency in late osteoblasts/osteocytes (Dkk1f/f;Dmp1-Cre, cKO) and littermate control mice by 5 subsequent injections of streptozotocin (40 mg/kg). Age-matched, non-diabetic control groups received citrate buffer instead. At week 12, calvarial defects were created in subgroups of each cohort. After a total of 16 weeks, weight, fat, the femoral bone phenotype and the area of the bone defect were analyzed using µCT and dynamic histomorphometry. During the experiment, diabetic WT and cKO mice did not gain body weight compared to control mice. Further they lost their perigonadal and subcutaneous fat pads. Diabetic mice had highly elevated serum glucose levels and impaired glucose tolerance, regardless of their Dkk1 levels. T1DM led to a 36% decrease in trabecular bone volume in Cre− negative control animals, whereas Dkk1 cKO mice only lost 16%. Of note, Dkk1 cKO mice were completely protected from T1DM-induced cortical bone loss. T1DM suppressed the bone formation rate, the number of osteoblasts at trabecular bone, serum levels of P1NP and bone defect healing in both, Dkk1-deficient and sufficient, mice. This may be explained by increased serum sclerostin levels in both genotypes and the strict dependence on bone formation for bone defect healing. In contrast, the number of osteoclasts and TRACP 5b serum levels only increased in diabetic control mice, but not in Dkk1 cKO mice. In summary, Dkk1 derived from osteogenic cells does not influence the development of T1DM but plays a crucial role in T1DM-induced bone loss in male mice by regulating osteoclast numbers.

scholarly journals In vitro and in vivo assessment of nanostructured porous biphasic calcium phosphate ceramics for promoting osteogenesis in an osteoporotic environment

RSC Advances ◽  
2018 ◽  
Vol 8 (26) ◽  
pp. 14646-14653 ◽  
Author(s):  
Kun Zhang ◽  
Jieyu Zhang ◽  
Kelei Chen ◽  
Xuefeng Hu ◽  
Yunbing Wang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Defect ◽  
Biphasic Calcium Phosphate ◽  
Calcium Phosphate Ceramics ◽  
Defect Healing ◽  
Bone Defect Healing ◽  
In Vivo Assessment ◽  
Porous Biphasic Calcium Phosphate

Nanostructured porous biphasic calcium phosphate ceramics are able to significantly promote bone defect healing in an osteoporotic environment.

Evaluation of Bovine Bone Ash Particles for Tooth-Bearing Bone Defect Healing

2006 ◽  
pp. 37-40
Author(s):  
H.J. Kang ◽  
M.J. Cho ◽  
J.H. Lim ◽  
D.K. Kwon ◽  
J.M. Lee ◽  
...  
Keyword(s):  
Bone Defect ◽  
Bovine Bone ◽  
Defect Healing ◽  
Bone Defect Healing ◽  
Bone Ash

scholarly journals Systemically replicated organic and inorganic bony microenvironment for new bone formation generated by a 3D printing technology

RSC Advances ◽  
2016 ◽  
Vol 6 (14) ◽  
pp. 11546-11553 ◽  
Author(s):  
Wan-Gun La ◽  
Jinah Jang ◽  
Byoung Soo Kim ◽  
Min Suk Lee ◽  
Dong-Woo Cho ◽  
...  
Keyword(s):  
3D Printing ◽  
Bone Formation ◽  
Bone Defect ◽  
New Bone Formation ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Defect Healing ◽  
Bone Defect Healing ◽  
3D Printed

3D-printed bioimplants for enhanced bone defect healing using decellularized and demineralized ECM coating.

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