scholarly journals Roxatidine attenuates mast cell-mediated allergic inflammation via inhibition of NF-κB and p38 MAPK activation

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Minho Lee ◽  
Na Young Lee ◽  
Kyung-Sook Chung ◽  
Se-Yun Cheon ◽  
Kyung-Tae Lee ◽  
...  
Keyword(s):  
Mast Cell ◽  
P38 Mapk ◽  
Allergic Inflammation ◽  
Mapk Activation

scholarly journals Inhibition of the Stem Cell Factor-Induced Migration of Mast Cells by Dexamethasone

Endocrinology ◽  
2003 ◽  
Vol 144 (9) ◽  
pp. 4080-4086 ◽  
Author(s):  
Hyun-Ja Jeong ◽  
Ho-Jeong Na ◽  
Seung-Heon Hong ◽  
Hyung-Min Kim
Keyword(s):  
Mast Cell ◽  
Stem Cell ◽  
Mast Cells ◽  
P38 Mapk ◽  
Stem Cell Factor ◽  
Inflammatory Cytokine ◽  
Cytokine Production ◽  
Morphological Alteration ◽  
Mapk Activation ◽  
Inflammatory Cytokine Production

Abstract Mast cell accumulation can be causally related to several allergic inflammations. Previous work has demonstrated that glucocorticoids decreased tissue mast cell number, and stem cell factor (SCF)-induced migration of mast cells required p38 MAPK activation. In the present study we investigated the effects of dexamethasone on SCF-induced migration of rat peritoneal mast cells (RPMCs). SCF significantly induced the migration of RPMCs at 4 h. Dexamethasone dose-dependently inhibited SCF-induced migration of RPMCs (∼90.1% at 100 nm; P < 0.05). The MAPK p38 inhibitor SB203580 (20 μm) also inhibited the SCF-induced migration. The ability of SCF to enhance morphological alteration and filamentous actin formation was also abolished by treatment with dexamethasone. Dexamethasone inhibited SCF-induced p38 MAPK activation to near-basal levels and induced MAPK phosphatase-1 expression. In addition, SCF-induced inflammatory cytokine production was significantly inhibited by treatment with dexamethasone or SB203580 (P < 0.01). Our results show that dexamethasone potently regulates SCF-induced migration, p38 MAPK activation, and inflammatory cytokine production through the expression of MKP-1 protein in RPMCs. Such modulation may have functional consequences during dexamethasone treatment, especially mast cell-mediated allergic inflammation disorders.

scholarly journals GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yapeng Li ◽  
Junfeng Gao ◽  
Mohammad Kamran ◽  
Laura Harmacek ◽  
Thomas Danhorn ◽  
...  
Keyword(s):  
Mast Cell ◽  
Binding Sites ◽  
Cell Lineage ◽  
Allergic Inflammation ◽  
Chromatin Accessibility ◽  
Antigenic Stimulation ◽  
Parasitic Infections ◽  
Cell Identity ◽  
Super Enhancer ◽  
Determining Factors

AbstractMast cells are critical effectors of allergic inflammation and protection against parasitic infections. We previously demonstrated that transcription factors GATA2 and MITF are the mast cell lineage-determining factors. However, it is unclear whether these lineage-determining factors regulate chromatin accessibility at mast cell enhancer regions. In this study, we demonstrate that GATA2 promotes chromatin accessibility at the super-enhancers of mast cell identity genes and primes both typical and super-enhancers at genes that respond to antigenic stimulation. We find that the number and densities of GATA2- but not MITF-bound sites at the super-enhancers are several folds higher than that at the typical enhancers. Our studies reveal that GATA2 promotes robust gene transcription to maintain mast cell identity and respond to antigenic stimulation by binding to super-enhancer regions with dense GATA2 binding sites available at key mast cell genes.

scholarly journals cFLIP-L Inhibits p38 MAPK Activation

2003 ◽  
Vol 278 (29) ◽  
pp. 26831-26837 ◽  
Author(s):  
Annette Grambihler ◽  
Hajime Higuchi ◽  
Steven F. Bronk ◽  
Gregory J. Gores
Keyword(s):  
P38 Mapk ◽  
Mapk Activation

The Role of the Mast Cell in Acute and Chronic Allergic Inflammation

1994 ◽  
Vol 725 (1) ◽  
pp. 13-21 ◽  
Author(s):  
MARTIN K. CHURCH ◽  
YOSHIMICHI OKAYAMA ◽  
PETER BRADDING
Keyword(s):  
Mast Cell ◽  
Allergic Inflammation

p38 MAPK activation restores cardioprotection to the aged heart

2006 ◽  
Vol 41 (4) ◽  
pp. 743-743
Author(s):  
J. Peart ◽  
G. Gross ◽  
J. Headrick
Keyword(s):  
P38 Mapk ◽  
Mapk Activation

scholarly journals Hemin inhibits NO production by IL-1β-stimulated human astrocytes through induction of heme oxygenase-1 and reduction of p38 MAPK activation

2010 ◽  
Vol 7 (1) ◽  
pp. 51 ◽  
Author(s):  
Wen S Sheng ◽  
Shuxian Hu ◽  
Adam R Nettles ◽  
James R Lokensgard ◽  
Gregory M Vercellotti ◽  
...  
Keyword(s):  
P38 Mapk ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
No Production ◽  
Mapk Activation ◽  
Human Astrocytes

Effect of Chicoric Acid on Mast Cell-Mediated Allergic Inflammation in Vitro and in Vivo

2015 ◽  
Vol 78 (12) ◽  
pp. 2956-2962 ◽  
Author(s):  
Na Young Lee ◽  
Kyung-Sook Chung ◽  
Jong Sik Jin ◽  
Keuk Soo Bang ◽  
Ye-Jin Eom ◽  
...  
Keyword(s):  
Mast Cell ◽  
Allergic Inflammation ◽  
Chicoric Acid

Abrogation of NF-κB signaling in human neutrophils induces neutrophil survival through sustained p38-MAPK activation

2010 ◽  
Vol 88 (4) ◽  
pp. 655-664 ◽  
Author(s):  
Jeroen D. Langereis ◽  
Hanneke A. J. A. Raaijmakers ◽  
Laurien H. Ulfman ◽  
Leo Koenderman
Keyword(s):  
P38 Mapk ◽  
Human Neutrophils ◽  
Mapk Activation ◽  
Neutrophil Survival
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