scholarly journals Evaluation of the impact of polyclonal infection and heteroresistance on treatment of tuberculosis patients

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Mansour Kargarpour Kamakoli ◽  
Hamid Reza Sadegh ◽  
Ghazaleh Farmanfarmaei ◽  
Morteza Masoumi ◽  
Abolfazl Fateh ◽  
...  
Pharmacy ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 86
Author(s):  
Fauna Herawati ◽  
Yuni Megawati ◽  
Aslichah ◽  
Retnosari Andrajati ◽  
Rika Yulia

The long period of tuberculosis treatment causes patients to have a high risk of forgetting or stopping the medication altogether, which increases the risk of oral anti-tuberculosis drug resistance. The patient’s knowledge and perception of the disease affect the patient’s adherence to treatment. This research objective was to determine the impact of educational videos in the local language on the level of knowledge, perception, and adherence of tuberculosis patients in the Regional General Hospital (RSUD) Bangil. This quasi-experimental study design with a one-month follow-up allocated 62 respondents in the intervention group and 60 in the control group. The pre- and post-experiment levels of knowledge and perception were measured with a validated set of questions. Adherence was measured by pill counts. The results showed that the intervention increases the level of knowledge of the intervention group higher than that of the control group (p-value < 0.05) and remained high after one month of follow-up. The perceptions domains that changed after education using Javanese (Ngoko) language videos with the Community Based Interactive Approach (CBIA) method were the timeline, personal control, illness coherence, and emotional representations (p-value < 0.05). More than 95% of respondents in the intervention group take 95% of their pill compared to 58% of respondents in the control group (p-value < 0.05). Utilization of the local languages for design a community-based interactive approach to educate and communicate is important and effective.


PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e76189 ◽  
Author(s):  
Dorai Deepa ◽  
Shanta Achanta ◽  
Jyoti Jaju ◽  
Koteswara Rao ◽  
Rani Samyukta ◽  
...  

Author(s):  
Mikhail Valerevich Sinitsyn ◽  
S. E. Borisov ◽  
E. M. Belilovskiy ◽  
E. M. Bogorodskaya

The study is devoted to the evaluation of the impact of the spread of HIV infection on the epidemiological indicators of tuberculosis in a megacity. Based on information from the registers of the tuberculosis monitoring system in Moscow for 2014-2015. A comparative analysis of indicators for patients with tuberculosis was conducted with the presence and absence of co-infected HIV infection. The results showed that among patients with tuberculosis combined with HIV infection, patients from the city’s permanent population, from the age group of 31-40 years old, non-working, injecting drug users are much more likely than other TB patients. The number of tuberculosis patients who died of HIV infection, in comparison with the number of patients who died from tuberculosis, accounted for more than a third of the total number of tuberculosis-related deaths. Thus, when assessing the epidemiological situation of tuberculosis, it is necessary to take into account the significant contribution of HIV infection to the values of the main indicators and their dynamics.


Author(s):  
Gagan Chooramani ◽  
Pooja Singh

The World Health Organization has declared that the spread of tuberculosis is a global emergency. Despite the implementation of strong tuberculosis-control initiatives by WHO, this highly infectious disease continues to affect all vulnerable populations, including the elderly population. Adverse social factors and poor living conditions also affect the elderly much more than the young. The clinical characteristics of tuberculosis in older adults can be unusual and may be confused with age-related illnesses. Various factors related to old age can also cause complications in the diagnosis, treatment, and disease outcomes for tuberculosis patients. The contributory factors may be poor memory, deafness, mental confusion, or impairment of speech. In addition, therapy for tuberculosis in elderly individuals is challenging because of the increased incidence of adverse drug reactions. Hence, understanding the impact of these substantial aspects will help to overcome the problem of tuberculosis in the elderly population.


2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Tegegn Mulatu Ayana ◽  
Kedir Teji Roba ◽  
Myrla Obejero Mabalhin

Abstract Background In developing countries, the prevalence of psychological distress was higher among tuberculosis patients. Patients with tuberculosis infection were more prone to psychological distress than peoples without tuberculosis. However, little studies were conducted on psychological distress among tuberculosis patients in Ethiopia, particularly in the Eastern Ethiopian health institutions. Methods Institution-based cross-sectional study design was conducted. Based on the TB burden, four hospitals and six health centers were selected from Dire Dawa and Harar cities. Socio-demographic factors, psychological distress, TB related stigma experience, and alcohol use data were collected by face to face interview while TB and HIV related variables collected from TB registration book. All TB patients from the first month of TB treatment initiation through 6 were consecutively interviewed by trained data collectors from January to February 2018. The collected data were entered into Epi Data Version 3.1 software and exported into SPSS window version 20 for analysis. Bivariate and multivariate binary logistic regression was carried out. All variables with P-value ≤0.25 were taken into the multivariate model. Crude and adjusted odds ratios with a 95% confidence interval were estimated, and variables with P-value less than 0.05 in the final model were taken as significant predictors of psychological distress. Results The prevalence of psychological distress among tuberculosis in this study population was 63.3% (95% CI: 58.1, 68.1). Being from rural residence (AOR: 1. 98; 95% CI: 1.01,3.86), co-infection TB- HIV (AOR: 2.15; 95% CI:1.02, 4.56), presence of at least one chronic disease (AOR:3.04; 95% CI:1.59,5.79), experience of stigma (AOR: 1.71; 95% CI:1.01, 2.90), Pulmonary and MDR-TB (AOR:2.53; 95% CI:1.50,4.28) and smoking cigarette (AOR:2.53; 95% CI:1.06,6.03) were associated with psychological distress. Conclusions In this study, almost two-thirds of the tuberculosis patients had psychological distress. Chronic disease morbidity, HIV-TB co-infection and experienced TB related stigma were associated with psychological distress. Attention should be given to chronic diseases including HIV/AIDS diagnosis and referring to chronic disease units to prevent the impact on mental health. Consideration should be given for psychological distress and linking moderate to severe form of the disease to the Psychiatric clinics to hinder its effects.


2017 ◽  
Vol 89 (4) ◽  
pp. 2911-2919 ◽  
Author(s):  
ANDREZA R.V. LOPES ◽  
SILVANA S. DE MIRANDA ◽  
MARIA DAS GRAÇAS B. CECCATO ◽  
MICHELINE R. SILVEIRA ◽  
NATÁLIA H. DE RESENDE ◽  
...  

Infection ◽  
2008 ◽  
Vol 36 (4) ◽  
pp. 335-340 ◽  
Author(s):  
C.-S. Wang ◽  
H.-C. Chen ◽  
C.-J. Yang ◽  
W.-Y. Wang ◽  
I.-W. Chong ◽  
...  

2020 ◽  
Author(s):  
Han Nguyen ◽  
Khan Mai Xuan ◽  
Tuan Nguyen Chi ◽  
Tung Nguyen Thanh ◽  
Quyet Do

Abstract Background: According to the Global Tuberculosis Report 2019, Vietnam is one of the 20 countries with the highest TB prevalence in the world. Pulmonary tuberculosis has a significant effect on lung functions, causing many obstacles in daily activities and affects the quality of patient’s lives.Methods: The case-series study conducted on 43 newly-diagnosed pulmonary tuberculosis patients at the Department of Tuberculosis - Military Hospital 103 within 4 months. The aims of the current study were to evaluate the validity of the Vietnamese version of the St. George's Respiratory Questionnaire and to investigate the relationship between SGRQ scores and the clinical and subclinical symptoms in new pulmonary tuberculosis patients.Results: The results indicate that Vietnamese version of the SGRQ has high reliability with Cronbach's alpha of Total score was 0.9451, Cronbach's alpha of all domains was above 0.6, of which the Symptom domain was 0.6635, the Impact domain was 0.9069, the Activity domain was 0.9121. The study also showed that SGRQ score was proportional to the aggregate size of all cavities on chest X-ray (r = 0.3772) and inversely proportional to BMI (r = -0.2843), MGIT days to positivity (r = -0.1635).Conclusions: The Vietnamese version of the SGRQ is a highly reliable and valuable questionnaire in assessing symptoms and life effects in new PTB patients. We recommend it as symptom measurement and quality of life evaluation in patients with new PTB in future studies.Trial registration: The study protocol was approved by the Ethical Review Board Committee of Vietnam Military Medical University (IRB No. 250/2020/QĐ-HVQY) and by the local ethics committee of Military hospital 103. All participants had provided written informed consents for this study.


2019 ◽  
Vol 26 (5) ◽  
pp. E5-E12
Author(s):  
Suzanne M. Marks ◽  
Dolly J. Katz ◽  
Amy L. Davidow ◽  
Melissa A. Pagaoa ◽  
Larry D. Teeter ◽  
...  

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