scholarly journals Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Shuquan Rao ◽  
Yao Yao ◽  
Joanne Ryan ◽  
Chunhui Jin ◽  
Yong Xu ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Genetic Association ◽  
Chinese Populations ◽  
Schizophrenia Susceptibility

scholarly journals Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations

2009 ◽  
Vol 18 (24) ◽  
pp. 4897-4904 ◽  
Author(s):  
Yang Li ◽  
Wen-Jing Wang ◽  
Huiqing Cao ◽  
Jiehua Lu ◽  
Chong Wu ◽  
...  
Keyword(s):  
Genetic Association ◽  
Han Chinese ◽  
Chinese Populations

scholarly journals Association of the PINX1 Variant rs6984094, Which Lengthens Telomeres, with Systemic Lupus Erythematosus Susceptibility in Chinese Populations

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Yuan-yuan Qi ◽  
Xin-ran Liu ◽  
Ying-xin He ◽  
Min Zhou ◽  
Xiang-hui Ning ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Genetic Association ◽  
Lupus Erythematosus ◽  
Genome Wide Association Study ◽  
Mononuclear Cells ◽  
Critical Role ◽  
Systemic Lupus ◽  
Peripheral Blood Mononuclear ◽  
Chinese Populations ◽  
Genetic Heritability

A recent genome-wide association study (GWAS) of Asian ancestry reported that single nucleotide polymorphism (SNP) in TERT (telomerase reverse transcriptase) was associated with systemic lupus erythematosus (SLE). TERT has a critical role in maintaining the chromosomal stability and the length of telomere. Given that only a small portion of the genetic heritability of SLE has been explained so far, we aimed to identify novel loci in telomere-related genes responsible for SLE susceptibility in Chinese populations. We performed a comprehensive genetic association analysis of SLE with telomere-related genes. To identify functional significance, we analyzed the publicly available HaploReg v4.1 and RegulomeDB databases. Differential gene expression analysis was also performed using ArrayExpress. A novel signal of PINX1 rs6984094 was identified ( P discovery = 4.13 × 10 − 2 , OR = 0.58 , 95% CI 0.35-0.98) and successfully replicated ( P replication = 5.73 × 10 − 3 , OR = 0.45 , 95% CI 0.26-0.81). Multiple layers of functional analysis suggested that the PINX1 rs6984094 risk T allele exhibited increased nuclear protein binding. We also observed an increased expression of PINX1 mRNA in peripheral blood mononuclear cells from SLE patients compared with healthy controls. Overall, we observed a novel genetic association between PINX1 (encodes the PinX1 protein, an inhibitory telomerase enzyme that lengthens telomeres) and SLE susceptibility in Chinese populations.

scholarly journals Genetic association of the Phosphoinositide‐3 kinase in schizophrenia and bipolar disorder and interaction with a BDNF gene polymorphism

2011 ◽  
Vol 1 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Anthony Carrard ◽  
Annick Salzmann ◽  
Nader Perroud ◽  
Jérémie Gafner ◽  
Alain Malafosse ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Gene Polymorphism ◽  
Genetic Association ◽  
Bdnf Gene ◽  
Phosphoinositide 3 Kinase

The genetic association of DUSP6 with bipolar disorder and its effect on ERK activity

2011 ◽  
Vol 26 ◽  
pp. e172
Author(s):  
Se Hyun Kim ◽  
Kyu Young Lee ◽  
Soon Young Shin ◽  
Eun Jeong Joo ◽  
Joo Youn Song ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Genetic Association ◽  
Erk Activity

scholarly journals Genetic association of cyclic AMP signaling genes with bipolar disorder

2012 ◽  
Vol 2 (10) ◽  
pp. e169-e169 ◽  
Author(s):  
M-L McDonald ◽  
C MacMullen ◽  
D J Liu ◽  
S M Leal ◽  
R L Davis
Keyword(s):  
Bipolar Disorder ◽  
Cyclic Amp ◽  
Genetic Association ◽  
Cyclic Amp Signaling

scholarly journals Genetic association of bipolar disorder with the β3 nicotinic receptor subunit gene

2011 ◽  
Vol 21 (2) ◽  
pp. 77-84 ◽  
Author(s):  
Sarah M. Hartz ◽  
Peng Lin ◽  
Howard J. Edenberg ◽  
Xiaoling Xuei ◽  
Nanette Rochberg ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Genetic Association ◽  
Nicotinic Receptor ◽  
Receptor Subunit ◽  
Subunit Gene
Sign in / Sign up

Export Citation Format

Share Document