scholarly journals Clinical Roles of Lung Volumes Detected by Body Plethysmography and Helium Dilution in Asthmatic Patients: A Correlation and Diagnosis Analysis

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jian Luo ◽  
Dan Liu ◽  
Guo Chen ◽  
Binmiao Liang ◽  
Chuntao Liu
Keyword(s):  
Body Plethysmography ◽  
Lung Volumes ◽  
Asthmatic Patients ◽  
Helium Dilution

scholarly journals Can the single-breath helium dilution method predict lung volumes as measured by whole-body plethysmography?

2013 ◽  
Vol 39 (6) ◽  
pp. 675-685 ◽  
Author(s):  
Patrícia Chaves Coertjens ◽  
Marli Maria Knorst ◽  
Anelise Dumke ◽  
Adriane Schmidt Pasqualoto ◽  
João Riboldi ◽  
...  
Keyword(s):  
Lung Function ◽  
Whole Body ◽  
Normal Lung ◽  
Regression Equations ◽  
Body Plethysmography ◽  
Lung Volumes ◽  
Single Breath ◽  
Normal Lung Function ◽  
Helium Dilution ◽  
Whole Body Plethysmography

OBJECTIVE: To compare TLC and RV values obtained by the single-breath helium dilution (SBHD) method with those obtained by whole-body plethysmography (WBP) in patients with normal lung function, patients with obstructive lung disease (OLD), and patients with restrictive lung disease (RLD), varying in severity, and to devise equations to estimate the SBHD results.METHODS: This was a retrospective cross-sectional study involving 169 individuals, of whom 93 and 49 presented with OLD and RLD, respectively, the remaining 27 having normal lung function. All patients underwent spirometry and lung volume measurement by both methods.RESULTS: TLC and RV were higher by WBP than by SBHD. The discrepancy between the methods was more pronounced in the OLD group, correlating with the severity of airflow obstruction. In the OLD group, the correlation coefficient of the comparison between the two methods was 0.57 and 0.56 for TLC and RV, respectively (p < 0.001 for both). We used regression equations, adjusted for the groups studied, in order to predict the WBP values of TLC and RV, using the corresponding SBHD values. It was possible to create regression equations to predict differences in TLC and RV between the two methods only for the OLD group. The TLC and RV equations were, respectively, ∆TLCWBP-SBHD in L = 5.264 − 0.060 × FEV1/FVC (r2= 0.33; adjusted r2 = 0.32) and ∆RVWBP-SBHD in L = 4.862 − 0.055 × FEV1/FVC (r2= 0.31; adjusted r2 = 0.30).CONCLUSIONS: The correction of TLC and RV results obtained by SBHD can improve the accuracy of this method for assessing lung volumes in patients with OLD. However, additional studies are needed in order to validate these equations.

Ventilation Heterogeneity in Asthma and COPD: The Value of the Poorly Communicating Fraction as the Ratio of Total Lung Capacity to Alveolar Volume

Respiration ◽  
2021 ◽  
pp. 1-7
Author(s):  
Roberta Pisi ◽  
Marina Aiello ◽  
Luigino Calzetta ◽  
Annalisa Frizzelli ◽  
Veronica Alfieri ◽  
...  
Keyword(s):  
Total Lung Capacity ◽  
Airflow Obstruction ◽  
Diffusing Capacity ◽  
Body Plethysmography ◽  
Alveolar Volume ◽  
Asthmatic Patients ◽  
Lung Capacity ◽  
Copd Patients ◽  
Ventilation Heterogeneity ◽  
Patient Groups

<b><i>Background:</i></b> The ventilation heterogeneity (VH) is reliably assessed by the multiple-breath nitrogen washout (MBNW), which provides indices of conductive (<i>S</i><sub>cond</sub>) and acinar (<i>S</i><sub>acin</sub>) VH as well as the lung clearance index (LCI), an index of global VH. VH can be alternatively measured by the poorly communicating fraction (PCF), that is, the ratio of total lung capacity by body plethysmography to alveolar volume from the single-breath lung diffusing capacity measurement. <b><i>Objectives:</i></b> Our objective was to assess VH by PCF and MBNW in patients with asthma and with COPD and to compare PCF and MBNW parameters in both patient groups. <b><i>Method:</i></b> We studied 35 asthmatic patients and 45 patients with COPD. Each patient performed spirometry, body plethysmography, diffusing capacity, and MBNW test. <b><i>Results:</i></b> Compared to COPD patients, asthmatics showed a significantly lesser degree of airflow obstruction and lung hyperinflation. In asthmatic patients, both PCF and LCI and <i>S</i><sub>acin</sub> values were significantly lower than the corresponding ones of COPD patients. In addition, in both patient groups, PCF showed a positive correlation with LCI (<i>p</i> &#x3c; 0.05) and <i>S</i><sub>acin</sub> (<i>p</i> &#x3c; 0.05), but not with <i>S</i><sub>cond</sub>. Lastly, COPD patients with PCF &#x3e;30% were highly likely to have a value ≥2 of the mMRC dyspnea scale. <b><i>Conclusions:</i></b> These results showed that PCF, a readily measure derived from routine pulmonary function testing, can provide a comprehensive measure of both global and acinar VH in asthma and in COPD patients and can be considered as a comparable tool to the well-established MBNW technique.

scholarly journals Flow-Volume Parameters in COPD Related to Extended Measurements of Lung Volume, Diffusion, and Resistance

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Linnea Jarenbäck ◽  
Jaro Ankerst ◽  
Leif Bjermer ◽  
Ellen Tufvesson
Keyword(s):  
Lung Function ◽  
Forced Expiratory Volume ◽  
Flow Volume ◽  
Impulse Oscillometry ◽  
Body Plethysmography ◽  
Additional Information ◽  
Single Breath ◽  
Gold Stage ◽  
Copd Patients ◽  
Helium Dilution

Classification of COPD into different GOLD stages is based on forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) but has shown to be of limited value. The aim of the study was to relate spirometry values to more advanced measures of lung function in COPD patients compared to healthy smokers. The lung function of 65 COPD patients and 34 healthy smokers was investigated using flow-volume spirometry, body plethysmography, single breath helium dilution with CO-diffusion, and impulse oscillometry. All lung function parameters, measured by body plethysmography, CO-diffusion, and impulse oscillometry, were increasingly affected through increasing GOLD stage but did not correlate with FEV1within any GOLD stage. In contrast, they correlated fairly well with FVC%p, FEV1/FVC, and inspiratory capacity. Residual volume (RV) measured by body plethysmography increased through GOLD stages, while RV measured by helium dilution decreased. The difference between these RV provided valuable additional information and correlated with most other lung function parameters measured by body plethysmography and CO-diffusion. Airway resistance measured by body plethysmography and impulse oscillometry correlated within COPD stages. Different lung function parameters are of importance in COPD, and a thorough patient characterization is important to understand the disease.

Failure of body plethysmography in bronchial asthma

1982 ◽  
Vol 52 (4) ◽  
pp. 939-948 ◽  
Author(s):  
D. C. Stanescu ◽  
D. Rodenstein ◽  
M. Cauberghs ◽  
K. P. Van de Woestijne
Keyword(s):  
Airway Obstruction ◽  
Esophageal Pressure ◽  
Mean Difference ◽  
Lung Mechanics ◽  
Body Plethysmography ◽  
Asthmatic Patients ◽  
Thoracic Gas Volume ◽  
Volume Measurements ◽  
Acute Changes ◽  
Extrathoracic Airway

To determine whether acute changes in lung volumes in asthma are accurately measured by body plethysmography, we induced acute changes in lung mechanics with acetylcholine in nine asthmatic patients and with salbutamol in six others. Total lung capacity (TLC) was measured with a body plethysmograph and derived from mouth pressure vs. box volume (Vbox) changes (TLCm) or esophageal pressure vs. Vbox changes (TLCes). In six patients (4 after acetylcholine) TLCm was significantly (P less than 0.05) different from prechallenge values (differences ranged from 0.29 to 1.55 liters), but TLCes did not change. In three additional patients both TLCm (mean difference 0.62 liter) and TLCes (mean difference 0.43 liter) changed (P less than 0.05), but no changes occurred in six others. An electrical analog of the lung demonstrates in the presence of intrathoracic airway obstruction overestimation of thoracic gas volume and TLC. This is due to the presence of a compliant extrathoracic airway that acts as a shunt impedance. The magnitude of the overestimation of TGV appears to depend on the distensibility of the extrathoracic airway and the degree of airway obstruction. We conclude that the plethysmographic method may introduce important errors in lung volume measurements in the obstructive syndrome, especially a severe one. Some of previously reported acute increases in TLC in asthmatics may be artifactual.

The Measurement of Lung Volumes Using Body Plethysmography: A Comparison of Methodologies

2012 ◽  
Vol 57 (7) ◽  
pp. 1076-1083 ◽  
Author(s):  
Brigitte M Borg ◽  
Bruce R Thompson
Keyword(s):  
Body Plethysmography ◽  
Lung Volumes

scholarly journals Official ERS technical standard: Global Lung Function Initiative reference values for static lung volumes in individuals of European ancestry

2021 ◽  
Vol 57 (3) ◽  
pp. 2000289
Author(s):  
Graham L. Hall ◽  
Nicole Filipow ◽  
Gregg Ruppel ◽  
Tolu Okitika ◽  
Bruce Thompson ◽  
...  
Keyword(s):  
Lung Function ◽  
Lung Volume ◽  
Additive Models ◽  
European Ancestry ◽  
Reference Ranges ◽  
Body Plethysmography ◽  
Lung Volumes ◽  
Reference Equations ◽  
Gas Dilution ◽  
The Impact

BackgroundMeasurement of lung volumes across the life course is critical to the diagnosis and management of lung disease. The aim of the study was to use the Global Lung Function Initiative methodology to develop all-age multi-ethnic reference equations for lung volume indices determined using body plethysmography and gas dilution techniques.MethodsStatic lung volume data from body plethysmography and gas dilution techniques from individual, healthy participants were collated. Reference equations were derived using the LMS (lambda-mu-sigma) method and the generalised additive models of location shape and scale programme in R. The impact of measurement technique, equipment type and being overweight or obese on the derived lung volume reference ranges was assessed.ResultsData from 17 centres were submitted and reference equations were derived from 7190 observations from participants of European ancestry between the ages of 5 and 80 years. Data from non-European ancestry populations were insufficient to develop multi-ethnic equations. Measurements of functional residual capacity (FRC) collected using plethysmography and dilution techniques showed physiologically insignificant differences and were combined. Sex-specific reference equations including height and age were developed for total lung capacity (TLC), FRC, residual volume (RV), inspiratory capacity, vital capacity, expiratory reserve volume and RV/TLC. The derived equations were similar to previously published equations for FRC and TLC, with closer agreement during childhood and adolescence than in adulthood.ConclusionsGlobal Lung Function Initiative reference equations for lung volumes provide a generalisable standard for reporting and interpretation of lung volumes measurements in individuals of European ancestry.

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