scholarly journals Intratumoral and peritumoral lymphatic vessel density both correlate with lymph node metastasis in breast cancer

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Song Zhang ◽  
Shanhong Yi ◽  
Dong Zhang ◽  
Mingfu Gong ◽  
Yuanqing Cai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Lymphatic Vessel ◽  
Vessel Density ◽  
Lymphatic Vessel Density ◽  
Node Metastasis

Clinical significance of FAP-α on microvessel and lymphatic vessel density in lung squamous cell carcinoma

2018 ◽  
Vol 71 (8) ◽  
pp. 721-728 ◽  
Author(s):  
Ling Chen ◽  
Meihui Chen ◽  
Zenglei Han ◽  
Fengxing Jiang ◽  
Chunyuan Xu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymphatic Vessel ◽  
Lung Squamous Cell Carcinoma ◽  
Vessel Density ◽  
Lymphatic Vessel Density ◽  
Node Metastasis

AimsWe aimed to determine whether cancer-associated fibroblasts (CAFs) are associated with microvessel density (MVD) and lymphatic vessel density (LVD) in lung squamous cell carcinoma, as well as their clinical significance in predicting survival.Methods122 patients were enrolled in the study. Samples were obtained on resection at the Department of Thoracic Surgery of the Qingdao Municipal Hospital between January 2011 and December 2014. Immunohistochemistry was used to determine vessel and lymphatic vessel density, and CAF abundance (fibroblast activation protein α (FAP-α) positivity). Statistical analyses were performed on 85 patients to test for correlation of CAF density and other clinicopathological variables with 3-year overall survival (OS) and disease-free survival (DFS).ResultsHigh stromal CAF abundance significantly correlated with increased MVD and LVD in lung squamous cell carcinoma (p<0.05). χ2 test revealed a significant association of CAF density with lymph node metastasis. Cox proportional hazards model showed that both higher CAF density and lymph node metastasis negatively correlate with survival. CAF density or lymph node status can be used as an independent prognostic factor to predict 3-year OS and DFS.ConclusionsCAF density, identified by FAP-α staining pattern, should be considered as a novel biomarker for disease prognosis in patients with lung squamous cell carcinoma.

scholarly journals Association of lymph vessel density with occult lymph node metastasis and prognosis in oral squamous cell carcinoma

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Simone E. S. Faustino ◽  
Kellen C. Tjioe ◽  
Agnes Assao ◽  
Michele C. Pereira ◽  
André L. Carvalho ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Squamous Cell ◽  
Lymphatic Vessel ◽  
Vessel Density ◽  
Lymph Vessel ◽  
Occult Metastasis ◽  
Lymphatic Vessel Density ◽  
Node Metastasis ◽  
Occult Lymph Node Metastasis

Abstract Background The aims of this study were to determine intra (ILVD) and peritumoral (PLVD) lymphatic vessel density (LVD), and to investigate the relationship of LVD with occult metastasis and prognosis. Methods Eighty-seven oral squamous cell carcinomas, in clinical stages I or II, arising in the tongue or floor of the mouth were stained with podoplanin. Lymphatic vessels were quantified in intra and peritumoral areas by sequential analysis and hot spot evaluation. Associations of the ILVD and PLVD with clinicopathologic parameters were determined by Chi-square or Fisher’s exact test. The 5 and 10-year survival rates were calculated by the Kaplan–Meier and compared using the log-rank test. Results No significant association was observed between ILVD or PLDV and clinicopathologic variables including occult lymph node metastasis, or clinical follow-up. However, ILVD showed a significant association with regional recurrence (p = 0.040). The perineural invasion was associated with PLVD (p = 0.041). Disease-specific (p = 0.044) and disease-free survivals (p = 0.016) had significant association with PLVD. Conclusions The intra or peritumoral lymphatic vessel density had no predictive value for occult lymph node metastasis in the early stages of oral cancer arising in the tongue or floor of mouth.

Increased Intratumoral Lymphatic Vessel Density Correlates with Lymph Node Metastasis in Early Gastric Carcinoma

2009 ◽  
Vol 17 (1) ◽  
pp. 73-80 ◽  
Author(s):  
Kyoungbun Lee ◽  
Do Joong Park ◽  
Gheeyoung Choe ◽  
Hyung Ho Kim ◽  
Woo Ho Kim ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Gastric Carcinoma ◽  
Lymphatic Vessel ◽  
Vessel Density ◽  
Early Gastric Carcinoma ◽  
Lymphatic Vessel Density ◽  
Node Metastasis

Lymphatic vessel density and lymph node metastasis in prostate cancer

The Prostate ◽  
2005 ◽  
Vol 65 (3) ◽  
pp. 222-230 ◽  
Author(s):  
Yiping Zeng ◽  
Kenneth Opeskin ◽  
Lisa G. Horvath ◽  
Robert L. Sutherland ◽  
Elizabeth D. Williams
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Lymphatic Vessel ◽  
Vessel Density ◽  
Lymphatic Vessel Density ◽  
Node Metastasis
Sign in / Sign up

Export Citation Format

Share Document