scholarly journals Local field potentials primarily reflect inhibitory neuron activity in human and monkey cortex

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Bartosz Teleńczuk ◽  
Nima Dehghani ◽  
Michel Le Van Quyen ◽  
Sydney S. Cash ◽  
Eric Halgren ◽  
...  
Keyword(s):  
Local Field ◽  
Local Field Potentials ◽  
Inhibitory Neuron ◽  
Neuron Activity ◽  
Field Potentials

Concomitant Single Neuron Activity, Local Field Potentials, and Cerebral Microdialysis in Neurosurgical Patients

Neurosurgery ◽  
1998 ◽  
Vol 43 (3) ◽  
pp. 706-706 ◽  
Author(s):  
Itzhak Fried ◽  
Eric Behnke ◽  
Nigel Maidment ◽  
Anatole Bragin ◽  
Katherine MacDonald ◽  
...  
Keyword(s):  
Local Field ◽  
Single Neuron ◽  
Local Field Potentials ◽  
Cerebral Microdialysis ◽  
Neuron Activity ◽  
Field Potentials ◽  
Neurosurgical Patients ◽  
Single Neuron Activity

scholarly journals Local Field Potentials and Spikes in the Human Medial Temporal Lobe are Selective to Image Category

2007 ◽  
Vol 19 (3) ◽  
pp. 479-492 ◽  
Author(s):  
Alexander Kraskov ◽  
Rodrigo Quian Quiroga ◽  
Leila Reddy ◽  
Itzhak Fried ◽  
Christof Koch
Keyword(s):  
Temporal Lobe ◽  
Local Field ◽  
Medial Temporal Lobe ◽  
Local Field Potentials ◽  
Neuron Activity ◽  
Separate Analysis ◽  
Field Potentials ◽  
Semantic Categories ◽  
Depth Electrodes ◽  
Neurosurgical Patients

Local field potentials (LFPs) reflect the averaged dendrosomatic activity of synaptic signals of large neuronal populations. In this study, we investigate the selectivity of LFPs and single neuron activity to semantic categories of visual stimuli in the medial temporal lobe of nine neurosurgical patients implanted with intracranial depth electrodes for clinical reasons. Strong selectivity to the category of presented images was found for the amplitude of LFPs in 8% of implanted microelectrodes and for the firing rates of single and multiunits in 14% of microelectrodes. There was little overlap between the LFP- and spike-selective microelectrodes. Separate analysis of the power and phase of LFPs revealed that the mean phase was category-selective around the θ frequency range and that the power of the LFPs was category-selective for high frequencies around the γ rhythm. Of the 36 microelectrodes with amplitude-selective LFPs, 30 were found in the hippocampus. Finally, it was possible to readout information about the category of stimuli presented to the patients with both spikes and LFPs. Combining spiking and LFP activity enhanced the decoding accuracy in comparison with the accuracy obtained with each signal alone, especially for short time intervals.

scholarly journals Altered Emotional Phenotypes in Chronic Kidney Disease Following 5/6 Nephrectomy

2021 ◽  
Vol 11 (7) ◽  
pp. 882
Author(s):  
Yeon Hee Yu ◽  
Seong-Wook Kim ◽  
Dae-Kyoon Park ◽  
Ho-Yeon Song ◽  
Duk-Soo Kim ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Local Field ◽  
Smooth Muscle Actin ◽  
Local Field Potentials ◽  
Renal Tissue ◽  
Field Potentials ◽  
Wild Type ◽  
Sprague Dawley ◽  
Rat Models

Increased prevalence of chronic kidney disease (CKD) and neurological disorders including cerebrovascular disease, cognitive impairment, peripheral neuropathy, and dysfunction of central nervous system have been reported during the natural history of CKD. Psychological distress and depression are serious concerns in patients with CKD. However, the relevance of CKD due to decline in renal function and the pathophysiology of emotional deterioration is not clear. Male Sprague Dawley rats were divided into three groups: sham control, 5/6 nephrectomy at 4 weeks, and 5/6 nephrectomy at 10 weeks. Behavior tests, local field potentials, and histology and laboratory tests were conducted and investigated. We provided direct evidence showing that CKD rat models exhibited anxiogenic behaviors and depression-like phenotypes, along with altered hippocampal neural oscillations at 1–12 Hz. We generated CKD rat models by performing 5/6 nephrectomy, and identified higher level of serum creatinine and blood urea nitrogen (BUN) in CKD rats than in wild-type, depending on time. In addition, the level of α-smooth muscle actin (α-SMA) and collagen I for renal tissue was markedly elevated, with worsening fibrosis due to renal failures. The level of anxiety and depression-like behaviors increased in the 10-week CKD rat models compared with the 4-week rat models. In the recording of local field potentials, the power of delta (1–4 Hz), theta (4–7 Hz), and alpha rhythm (7–12 Hz) was significantly increased in the hippocampus of CKD rats compared with wild-type rats. Together, our findings indicated that anxiogenic behaviors and depression can be induced by CKD, and these abnormal symptoms can be worsened as the onset of CKD was prolonged. In conclusion, our results show that the hippocampus is vulnerable to uremia.

Sign in / Sign up

Export Citation Format

Share Document