scholarly journals Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Elise Delage ◽  
Diégo Cordero Cervantes ◽  
Esthel Pénard ◽  
Christine Schmitt ◽  
Sylvie Syan ◽  
...  
Keyword(s):  
Tunneling Nanotubes ◽  
Differential Identity

Progress in promoting mechanism of tunneling nanotubes formation

2015 ◽  
Vol 36 (11) ◽  
pp. 1229
Author(s):  
Xiao-qing WANG ◽  
Xiao-wen YU ◽  
Ming-yuan LIU ◽  
Yang-tai GUAN
Keyword(s):  
Tunneling Nanotubes

scholarly journals Mitochondrial Transfer in Cancer: A Comprehensive Review

2021 ◽  
Vol 22 (6) ◽  
pp. 3245
Author(s):  
Luca X. Zampieri ◽  
Catarina Silva-Almeida ◽  
Justin D. Rondeau ◽  
Pierre Sonveaux
Keyword(s):  
Cancer Cells ◽  
Cancer Cell ◽  
Metabolic Pathways ◽  
Current Knowledge ◽  
Cancer Cell Proliferation ◽  
Tunneling Nanotubes ◽  
Comprehensive Review ◽  
Cancer Cell Death ◽  
Mitochondrial Transfer ◽  
Metabolic Activities

Depending on their tissue of origin, genetic and epigenetic marks and microenvironmental influences, cancer cells cover a broad range of metabolic activities that fluctuate over time and space. At the core of most metabolic pathways, mitochondria are essential organelles that participate in energy and biomass production, act as metabolic sensors, control cancer cell death, and initiate signaling pathways related to cancer cell migration, invasion, metastasis and resistance to treatments. While some mitochondrial modifications provide aggressive advantages to cancer cells, others are detrimental. This comprehensive review summarizes the current knowledge about mitochondrial transfers that can occur between cancer and nonmalignant cells. Among different mechanisms comprising gap junctions and cell-cell fusion, tunneling nanotubes are increasingly recognized as a main intercellular platform for unidirectional and bidirectional mitochondrial exchanges. Understanding their structure and functionality is an important task expected to generate new anticancer approaches aimed at interfering with gains of functions (e.g., cancer cell proliferation, migration, invasion, metastasis and chemoresistance) or damaged mitochondria elimination associated with mitochondrial transfer.

Two routes of direct intercellular communication in brain cancer

2021 ◽  
Vol 478 (6) ◽  
pp. 1283-1286
Author(s):  
Daniel D. Azorín ◽  
Frank Winkler
Keyword(s):  
Tumor Cells ◽  
Brain Cancer ◽  
State Of The Art ◽  
Tumor Resistance ◽  
Tunneling Nanotubes ◽  
Functional Studies ◽  
Membrane Tube ◽  
Biochemical Journal ◽  
Culture Model ◽  
Health And Disease

Glioblastoma is a particularly challenging disease characterized by the connection of tumor cells to functional multicellular networks that effectively resist therapies. In this issue of Biochemical Journal, Pinto et al. report the discovery of two distinct classes of intercellular membrane tube connections, tunneling nanotubes and tumor microtubes, in the same state-of-the-art culture model of patient-derived glioblastoma material. These findings contribute to our understanding of the heterogeneity of intercellular membrane tubes in health and disease, and pave the way for future functional studies on their various roles for disease progression and tumor resistance.

scholarly journals Tunneling Nanotubes are Novel Cellular Structures That Communicate Signals Between Trabecular Meshwork Cells

2017 ◽  
Vol 58 (12) ◽  
pp. 5298 ◽  
Author(s):  
Kate E. Keller ◽  
John M. Bradley ◽  
Ying Ying Sun ◽  
Yong-Feng Yang ◽  
Ted S. Acott
Keyword(s):  
Trabecular Meshwork ◽  
Cellular Structures ◽  
Tunneling Nanotubes ◽  
Trabecular Meshwork Cells

Tunneling Nanotubes

2010 ◽  
pp. 170-171
Author(s):  
Margit Pavelka ◽  
Jürgen Roth
Keyword(s):  
Tunneling Nanotubes

scholarly journals Investigating tunneling nanotubes in ovariancancer based on two-photon excitation FLIMFRET

2021 ◽  
Author(s):  
ShiQi Wang ◽  
yanping li ◽  
Yihua zhao ◽  
Fangrui Lin ◽  
Junle Qu ◽  
...  
Keyword(s):  
Tunneling Nanotubes ◽  
Two Photon ◽  
Photon Excitation ◽  
Two Photon Excitation

scholarly journals Intra- and Intercellular Quality Control Mechanisms of Mitochondria

2017 ◽  
Author(s):  
Yoshimitsu Kiriyama ◽  
Hiromi Nochi
Keyword(s):  
Quality Control ◽  
Cell Death ◽  
Extracellular Vesicles ◽  
Mitochondrial Function ◽  
Current Knowledge ◽  
Control Mechanisms ◽  
Tunneling Nanotubes ◽  
Cellular Homeostasis

Mitochondria function to generate ATP and also play important roles in cellular homeostasis, signaling, apoptosis, autophagy, and metabolism. The loss of mitochondrial function results in cell death and various types of diseases. Therefore, quality control of mitochondria via intra- and intercellular pathways is crucial. Intracellular quality control consists of biogenesis, fusion and fission, and degradation of mitochondria in the cell, whereas intercellular quality control involves tunneling nanotubes and extracellular vesicles. In this review, we outline the current knowledge on the intra- and intercellular quality control mechanisms of mitochondria.

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