scholarly journals Passive immunization with anti-ActA and anti-listeriolysin O antibodies protects against Listeria monocytogenes infection in mice

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Krisana Asano ◽  
Hiroshi Sashinami ◽  
Arihiro Osanai ◽  
Shouhei Hirose ◽  
Hisaya K. Ono ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Passive Immunization ◽  
Listeriolysin O ◽  
Listeria Monocytogenes Infection

scholarly journals Listeriolysin O Is Necessary and Sufficient to Induce Autophagy during Listeria monocytogenes Infection

PLoS ONE ◽  
2010 ◽  
Vol 5 (1) ◽  
pp. e8610 ◽  
Author(s):  
Nicole Meyer-Morse ◽  
Jennifer R. Robbins ◽  
Chris S. Rae ◽  
Sofia N. Mochegova ◽  
Michele S. Swanson ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Listeriolysin O ◽  
Listeria Monocytogenes Infection ◽  
Necessary And Sufficient

scholarly journals Listeriolysin O Suppresses Phospholipase C-Mediated Activation of the Microbicidal NADPH Oxidase to Promote Listeria monocytogenes Infection

2011 ◽  
Vol 10 (6) ◽  
pp. 627-634 ◽  
Author(s):  
Grace Y. Lam ◽  
Ramzi Fattouh ◽  
Aleixo M. Muise ◽  
Sergio Grinstein ◽  
Darren E. Higgins ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Nadph Oxidase ◽  
Phospholipase C ◽  
Listeriolysin O ◽  
Listeria Monocytogenes Infection

Inhibition of listeriolysin O oligomerization by lutein prevents Listeria monocytogenes infection

Fitoterapia ◽  
2017 ◽  
Vol 116 ◽  
pp. 45-50 ◽  
Author(s):  
Bowen Liu ◽  
Zihao Teng ◽  
Jianfeng Wang ◽  
Gejin Lu ◽  
Xuming Deng ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Listeriolysin O ◽  
Listeria Monocytogenes Infection

scholarly journals The cell biology of Listeria monocytogenes infection

2002 ◽  
Vol 158 (3) ◽  
pp. 409-414 ◽  
Author(s):  
Daniel A. Portnoy ◽  
Victoria Auerbuch ◽  
Ian J. Glomski
Keyword(s):  
Listeria Monocytogenes ◽  
Host Cell ◽  
Cell Biology ◽  
Productive Infection ◽  
Acquired Immunity ◽  
Listeriolysin O ◽  
Listeria Monocytogenes Infection ◽  
Infected Cells ◽  
Fail Safe

Listeria monocytogenes has emerged as a remarkably tractable pathogen to dissect basic aspects of cell biology, intracellular pathogenesis, and innate and acquired immunity. In order to maintain its intracellular lifestyle, L. monocytogenes has evolved a number of mechanisms to exploit host processes to grow and spread cell to cell without damaging the host cell. The pore-forming protein listeriolysin O mediates escape from host vacuoles and utilizes multiple fail-safe mechanisms to avoid causing toxicity to infected cells. Once in the cytosol, the L. monocytogenes ActA protein recruits host cell Arp2/3 complexes and enabled/vasodilator-stimulated phosphoprotein family members to mediate efficient actin-based motility, thereby propelling the bacteria into neighboring cells. Alteration in any of these processes dramatically reduces the ability of the bacteria to establish a productive infection in vivo.

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