scholarly journals Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Tsuyoshi Shuto ◽  
Shunsuke Kamei ◽  
Hirofumi Nohara ◽  
Haruka Fujikawa ◽  
Yukihiro Tasaki ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Model ◽  
Lung Diseases ◽  
Obstructive Lung Diseases ◽  
And Oxidative Stress

A multifunctional compound ebselen reverses memory impairment, apoptosis and oxidative stress in a mouse model of sporadic Alzheimer's disease

2019 ◽  
Vol 109 ◽  
pp. 107-117 ◽  
Author(s):  
Franciele Martini ◽  
Suzan Gonçalves Rosa ◽  
Isabella Pregardier Klann ◽  
Bruna Cruz Weber Fulco ◽  
Fabiano Barbosa Carvalho ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Memory Impairment ◽  
Sporadic Alzheimer’S Disease ◽  
And Oxidative Stress

scholarly journals Mechanisms and consequences of oxidative stress in lung disease: therapeutic implications for an aging populace

2018 ◽  
Vol 314 (4) ◽  
pp. L642-L653 ◽  
Author(s):  
Louise Hecker
Keyword(s):  
Oxidative Stress ◽  
Lung Disease ◽  
Lung Diseases ◽  
The Elderly ◽  
Therapeutic Strategies ◽  
Rapid Expansion ◽  
Pulmonary Diseases ◽  
Normal Lung ◽  
Incidence And Mortality ◽  
And Oxidative Stress

The rapid expansion of the elderly population has led to the recent epidemic of age-related diseases, including increased incidence and mortality of chronic and acute lung diseases. Numerous studies have implicated aging and oxidative stress in the pathogenesis of various pulmonary diseases; however, despite recent advances in these fields, the specific contributions of aging and oxidative stress remain elusive. This review will discuss the consequences of aging on lung morphology and physiology, and how redox imbalance with aging contributes to lung disease susceptibility. Here, we focus on three lung diseases for which aging is a significant risk factor: acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF). Preclinical and clinical development for redox- and senescence-altering therapeutic strategies are discussed, as well as scientific advancements that may direct current and future therapeutic development. A deeper understanding of how aging impacts normal lung function, redox balance, and injury-repair processes will inspire the development of new therapies to prevent and/or reverse age-associated pulmonary diseases, and ultimately increase health span and longevity. This review is intended to encourage basic, clinical, and translational research that will bridge knowledge gaps at the intersection of aging, oxidative stress, and lung disease to fuel the development of more effective therapeutic strategies for lung diseases that disproportionately afflict the elderly.

Presymptomatic Alterations in Energy Metabolism and Oxidative Stress in the APP23 Mouse Model of Alzheimer Disease

2012 ◽  
Vol 11 (6) ◽  
pp. 3295-3304 ◽  
Author(s):  
Daniela Hartl ◽  
Victoria Schuldt ◽  
Stephanie Forler ◽  
Claus Zabel ◽  
Joachim Klose ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Energy Metabolism ◽  
Alzheimer Disease ◽  
Mouse Model ◽  
App23 Mouse ◽  
And Oxidative Stress

Comicronized PEA and Rutin reduces inflammation and oxidative stress in a mouse model of vascular injury

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Alessio Filippo peritore ◽  
Daniela Impellizzeri ◽  
Enrico Gugliandolo ◽  
Rosalba Siracusa ◽  
Roberta Fusco ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Model ◽  
Vascular Injury ◽  
And Oxidative Stress

scholarly journals Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation

2018 ◽  
Vol 15 (1) ◽  
Author(s):  
Joana Costa d’Avila ◽  
Luciana Domett Siqueira ◽  
Aurélien Mazeraud ◽  
Estefania Pereira Azevedo ◽  
Debora Foguel ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cognitive Impairment ◽  
Mouse Model ◽  
Systemic Inflammation ◽  
Age Related ◽  
And Oxidative Stress

Amelioration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced behavioural dysfunction and oxidative stress by Pycnogenol in mouse model of Parkinsonʼs disease

2010 ◽  
Vol 21 (5-6) ◽  
pp. 563-571 ◽  
Author(s):  
Mohammad Moshahid Khan ◽  
Md. Nasrul Hoda ◽  
Tauheed Ishrat ◽  
Ajmal Ahmad ◽  
Mohammad Badruzzaman Khan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Model ◽  
And Oxidative Stress
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