scholarly journals Genetic variation in IGF1 predicts renal cell carcinoma susceptibility and prognosis in Chinese population

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Qiang Cao ◽  
Chao Liang ◽  
Jianxin Xue ◽  
Pu Li ◽  
Jie Li ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Genetic Variation ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Chinese Population

hOGG1 Ser326Cys Polymorphism and Renal Cell Carcinoma Risk in a Chinese Population

2011 ◽  
Vol 30 (5) ◽  
pp. 317-321 ◽  
Author(s):  
Hu Zhao ◽  
Chao Qin ◽  
Fu Yan ◽  
Bin Wu ◽  
Qiang Cao ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Chinese Population ◽  
Ser326cys Polymorphism ◽  
Carcinoma Risk

Genetic association of polymorphisms inAXIN1gene with clear cell renal cell carcinoma in a Chinese population

2017 ◽  
Vol 11 (11) ◽  
pp. 947-955 ◽  
Author(s):  
Yan Pu ◽  
Xuhua Mi ◽  
Peng Chen ◽  
Bin Zhou ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Genetic Association ◽  
Renal Cell ◽  
Chinese Population ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma

scholarly journals Transcriptomic characterization and innovative molecular classification of clear cell renal cell carcinoma in the Chinese population

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Qiang Zhao ◽  
Jia Xue ◽  
Baoan Hong ◽  
Wubin Qian ◽  
Tiezhu Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Chinese Population ◽  
Clear Cell ◽  
Expression Profiles ◽  
Molecular Classification ◽  
The Cancer Genome Atlas ◽  
Cell Renal Cell Carcinoma

Abstract Background Large-scale initiatives like The Cancer Genome Atlas (TCGA) performed genomics studies on predominantly Caucasian kidney cancer. In this study, we aimed to investigate genomics of Chinese clear cell renal cell carcinoma (ccRCC). Methods We performed whole-transcriptomic sequencing on 55 tumor tissues and 11 matched normal tissues from Chinese ccRCC patients. We systematically analyzed the data from our cohort and comprehensively compared with the TCGA ccRCC cohort. Results It found that PBRM1 mutates with a frequency of 11% in our cohort, much lower than that in TCGA Caucasians (33%). Besides, 31 gene fusions including 5 recurrent ones, that associated with apoptosis, tumor suppression and metastasis were identified. We classified our cohort into three classes by gene expression. Class 1 shows significantly elevated gene expression in the VEGF pathway, while Class 3 has comparably suppressed expression of this pathway. Class 2 is characterized by increased expression of extracellular matrix organization genes and is associated with high-grade tumors. Applying the classification to TCGA ccRCC patients revealed better distinction of tumor prognosis than reported classifications. Class 2 shows worst survival and Class 3 is a rare subtype ccRCC in the TCGA cohort. Furthermore, computational analysis on the immune microenvironment of ccRCC identified immune-active and tolerant tumors with significant increased macrophages and depleted CD4 positive T-cells, thus some patients may benefit from immunotherapies. Conclusion In summary, results presented in this study shed light into distinct genomic expression profiles in Chinese population, modified the stratification patterns by new molecular classification, and gave practical guidelines on clinical treatment of ccRCC patients.

Association of Ku70 A-31G Polymorphism and Risk of Renal Cell Carcinoma in a Chinese Population

2012 ◽  
Vol 31 (7) ◽  
pp. 1314-1320 ◽  
Author(s):  
Wei Wang ◽  
Yanqin Gao ◽  
Fu Yan ◽  
Meilin Wang ◽  
Feifei Hu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Chinese Population

scholarly journals Genetic Variants in RKIP Are Associated with Clear Cell Renal Cell Carcinoma Risk in a Chinese Population

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e109285 ◽  
Author(s):  
Qiang Cao ◽  
Jian Wang ◽  
Mingcong Zhang ◽  
Pu Li ◽  
Jian Qian ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Genetic Variants ◽  
Renal Cell ◽  
Chinese Population ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Carcinoma Risk
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