scholarly journals Microarray analysis of long noncoding RNA and mRNA expression profiles in human macrophages infected with Mycobacterium tuberculosis

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Xiaofan Yang ◽  
Jiahui Yang ◽  
Jinli Wang ◽  
Qian Wen ◽  
Hui Wang ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Mrna Expression ◽  
Microarray Analysis ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Expression Profiles ◽  
Human Macrophages

scholarly journals Effects of Interleukin-1β on Long Noncoding RNA and mRNA Expression Profiles of Human Synovial Fluid-derived Mesenchymal Stem Cells

2021 ◽  
Author(s):  
Yang-peng Sun ◽  
Yun-yang Lu ◽  
Jianyu Chen ◽  
Jia-hao Bao ◽  
Hong Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Synovial Fluid ◽  
Mrna Expression ◽  
Temporomandibular Joint ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Expression Profiles ◽  
Biological Behavior ◽  
Antisense Lncrnas

Abstract Synovial fluid-derived mesenchymal stem cells (SFMSCs) play important regulatory roles in the physiological balance of the temporomandibular joint. Interleukin (IL)-1β regulates the biological behavior of SFMSCs; however, the effects of IL-1β on long noncoding RNA (lncRNA) and mRNA expression in SFMSCs in the temporomandibular joint are unclear. Here, we evaluated the lncRNA and mRNA expression profiles of IL-1β-stimulated SFMSCs. Using microarrays, we identified 286 lncRNAs (222 upregulated, 64 downregulated) and 304 mRNAs (242 upregulated, 62 downregulated) that were differentially expressed after treatment with IL-1β (fold change ≥ 2, P < 0.05). Kyoto Encyclopedia of Genes and Genomes pathway analysis found that one of the most significantly enriched pathways was the NF-κB pathway. Five paired antisense lncRNAs and mRNAs, eight paired enhancer lncRNAs and mRNAs, and nine paired long intergenic noncoding RNAs and mRNAs were predicted to be co-expressed. A network constructed by the top 30 k-score genes was visualized and evaluated. We found a co-expression relationship between ENST00000427824 and ENST00000307407 and between LOC541472 and IL6, which are related to NF-κB pathway activation. Overall, our results provide important insights into changes in lncRNA and mRNA expression in IL-1β-stimulated SFMSCs, which can facilitate the identification of potential therapeutic targets.

Long noncoding RNA‐mRNA expression profiles and validation in pancreatic neuroendocrine neoplasms

2020 ◽  
Vol 92 (4) ◽  
pp. 312-322 ◽  
Author(s):  
Meng Ji ◽  
Liang Tang ◽  
Rumei Ding ◽  
Ligang Shi ◽  
Anan Liu ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Expression Profiles ◽  
Neuroendocrine Neoplasms ◽  
Pancreatic Neuroendocrine Neoplasms

scholarly journals Long Noncoding RNA and mRNA Expression Profiles in the Thyroid Gland of Two Phenotypically Extreme Pig Breeds Using Ribo-Zero RNA Sequencing

Genes ◽  
2016 ◽  
Vol 7 (7) ◽  
pp. 34 ◽  
Author(s):  
Yifei Shen ◽  
Haiguang Mao ◽  
Minjie Huang ◽  
Lixing Chen ◽  
Jiucheng Chen ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Mrna Expression ◽  
Rna Sequencing ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Expression Profiles ◽  
Pig Breeds

scholarly journals Long Noncoding RNA Expression Profiles of Lung Adenocarcinoma Ascertained by Microarray Analysis

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e104044 ◽  
Author(s):  
Gang Xu ◽  
Jie Chen ◽  
Qinshi Pan ◽  
Keta Huang ◽  
Jingye Pan ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Microarray Analysis ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Expression Profiles ◽  
Rna Expression
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