scholarly journals Serum uric acid is independently and linearly associated with risk of nonalcoholic fatty liver disease in obese Chinese adults

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Chang-Qin Liu ◽  
Chun-Mei He ◽  
Ning Chen ◽  
Dongmei Wang ◽  
Xiulin Shi ◽  
...  
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Serum Uric Acid ◽  
Fatty Liver Disease ◽  
Chinese Adults ◽  
Nonalcoholic Fatty Liver

scholarly journals Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease in Lean Chinese Adults

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Ya-Nan Zhang ◽  
Qin-Qiu Wang ◽  
Yi-Shu Chen ◽  
Chao Shen ◽  
Cheng-Fu Xu
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Serum Uric Acid ◽  
Fatty Liver Disease ◽  
Hdl Cholesterol ◽  
Chinese Adults ◽  
Nonalcoholic Fatty Liver ◽  
Cholesterol Ratio

Background/Aim. The risk factors for nonalcoholic fatty liver disease (NAFLD) in lean population have not been fully clarified. This study aimed to explore the association between uric acid to HDL-cholesterol ratio (UHR) and NAFLD in lean Chinese adults. Methods. A cross-sectional study was performed among 6285 lean Chinese adults (body mass index < 24 kg/m2) who took their annual health checkups. NAFLD was diagnosed based on hepatic ultrasound examination, with exclusion of other etiologies. Results. Of 6285 lean participants enrolled, 654 NAFLD cases were diagnosed. The overall NAFLD prevalence was 10.41%, and the prevalence was 15.45% and 7.16% in men and women, respectively. UHR was significantly higher in NAFLD patients than in controls (14.25 ± 5.33% versus 10.09 ± 4.23%, P<0.001). UHR quintiles were positively associated with NAFLD prevalence, which was 1.91% in the first UHR quintile and increased to 3.58%, 7.81%, 14.17%, and 24.54% in the second, third, fourth, and fifth quintile groups, respectively (P<0.001 for trend). Multivariate logistic regression analysis showed that UHR was independently associated with an increased risk of NAFLD (odds ratio: 1.105; 95% CI: 1.076–1.134; P<0.001). Sensitivity analysis showed that UHR remained significantly associated with NAFLD in lean participants with normal range of serum uric acid and HDL-cholesterol levels. Conclusions. UHR was significantly associated with NAFLD and may serve as a novel and reliable marker for NAFLD in lean adults.

scholarly journals Association between Serum Uric Acid to HDL-cholesterol Ratio and Nonalcoholic Fatty Liver Disease among Chinese Adults

2021 ◽  
Author(s):  
Hui Zhao ◽  
Xia Qiu ◽  
Jiajia Cui ◽  
Yongye Sun
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Serum Uric Acid ◽  
Fatty Liver Disease ◽  
Hdl Cholesterol ◽  
Response Analysis ◽  
Chinese Adults ◽  
Nonalcoholic Fatty Liver

Abstract We conducted this case-control study to explore the association of serum uric acid (SUA) to HDL-cholesterol (HDL-C) ratio (UHR) with the risk of nonalcoholic fatty liver disease (NAFLD) in general Chinese adults. A total of 636 patients with NAFLD and 754 controls from affiliated hospital of Qingdao University in China between January to December 2016 were involved. NAFLD was diagnosed by ultrasonography after excluding other etiologies. The multivariable adjusted odds ratio and 95% confidence interval (CI) of NAFLD for the highest versus lowest quartile of UHR was 3.888 (2.324-6.504). In stratified analyses by sex and age, the positive associations between UHR and the risk of NAFLD were statistically significant in each subgroup. In stratified by BMI, the significant positive association was only found in the individuals with BMI≥23.9 kg/m2. Dose-response analysis indicated a linear positive correlation between UHR and NAFLD risk.

Can Serum Uric Acid Lowering Therapy Contribute to the Prevention or Treatment of Nonalcoholic Fatty Liver Disease?

2018 ◽  
Vol 16 (3) ◽  
pp. 269-275 ◽  
Author(s):  
Paschalis Paschos ◽  
Vasilios G. Athyros ◽  
Achilleas Tsimperidis ◽  
Anastasia Katsoula ◽  
Nikolaos Grammatikos ◽  
...  
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Serum Uric Acid ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Lowering Therapy

scholarly journals Serum Uric Acid Is a Mediator of the Association Between Obesity and Incident Nonalcoholic Fatty Liver Disease: A Prospective Cohort Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Qian Zhang ◽  
Xiaoqian Ma ◽  
Jie Xing ◽  
Haiyun Shi ◽  
Runkuan Yang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Serum Uric Acid ◽  
Mediation Analysis ◽  
Fatty Liver Disease ◽  
Total Population ◽  
Nonalcoholic Fatty Liver ◽  
Essential Components

ObjectiveObesity has been demonstrated to show a consistent link with the increased possibility of nonalcoholic fatty liver disease (NAFLD). Since both serum uric acid (SUA) and obesity are essential components of metabolic syndrome (MetS), it is uncertain whether the incidence of NAFLD results from serum uric acid, obesity, or other potential factors based on previous studies.Patients and methodsThis study enrolled 16,839 participants with no history of alcohol consumption and no fatty liver disease in 2010. All participants completed a survey which included health and lifestyle questionnaires, and underwent physical examination, ultrasonography, and laboratory examinations of blood samples. After the four-year follow up, 5,104 (30.31%) participants were diagnosed with NAFLD. The associations between SUA, BMI or obesity, and incident NAFLD were assessed by multivariate linear regression, logistic regression analysis, and mediation analysis, respectively.ResultsBy adjusting demographic and serum characteristics, linear correlation coefficients between obesity and SUA were 20.26 [95% confidence interval (CI)]: 15.74, 24.77), 13.31 (95% CI: 6.63, 19.99) and 22.21 (95% CI: 16.41, 28.02) in the total population, and in the female and male groups, respectively. The odds ratios were 2.49 (95% CI: 1.61, 3.87) in the total population, 5.71 (95% CI: 2.25, 14.45) in the female group and 1.99 (95% CI: 1.15, 3.45) in the male group for the correlation between obesity and incident NAFLD. The mediation analysis showed that SUA contributed to 10.03%, 0.58%, and 12.54% of obesity-related NAFLD development in the total population, females and males, respectively.ConclusionThe findings showed mediation linkages of both obesity and SUA with the incident NAFLD. The role of SUA as a mediator constitutes clinical significance that should be recognized and considered.

Serum uric acid levels predict incident nonalcoholic fatty liver disease in healthy Korean men

Metabolism ◽  
2011 ◽  
Vol 60 (6) ◽  
pp. 860-866 ◽  
Author(s):  
Seungho Ryu ◽  
Yoosoo Chang ◽  
Soo-Geun Kim ◽  
Juhee Cho ◽  
Eliseo Guallar
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Serum Uric Acid ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver

scholarly journals Association between serum uric acid and nonalcoholic fatty liver disease in the US population

2015 ◽  
Vol 114 (4) ◽  
pp. 314-320 ◽  
Author(s):  
Ming-Hsiung Shih ◽  
Mariana Lazo ◽  
Su-Hsun Liu ◽  
Susanne Bonekamp ◽  
Ruben Hernaez ◽  
...  
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Serum Uric Acid ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
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