scholarly journals G4IPDB: A database for G-quadruplex structure forming nucleic acid interacting proteins

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Subodh Kumar Mishra ◽  
Arpita Tawani ◽  
Amit Mishra ◽  
Amit Kumar
Keyword(s):  
Nucleic Acid ◽  
Interacting Proteins ◽  
Quadruplex Structure ◽  
G Quadruplex

scholarly journals Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 429 ◽  
Author(s):  
Sefan Asamitsu ◽  
Shunsuke Obata ◽  
Zutao Yu ◽  
Toshikazu Bando ◽  
Hiroshi Sugiyama
Keyword(s):  
Nucleic Acid ◽  
Secondary Structure ◽  
Recent Progress ◽  
Development Process ◽  
Protein Targeting ◽  
Molecular Probe ◽  
Drug Development Process ◽  
Quadruplex Structure ◽  
G4 Dna ◽  
G Quadruplex

A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-rich sequences, and has profound implications for various pharmacological and biological events, including cancers. Therefore, ligands interacting with G4s have attracted great attention as potential anticancer therapies or in molecular probe applications. To date, a large variety of DNA/RNA G4 ligands have been developed by a number of laboratories. As protein-targeting drugs face similar situations, G-quadruplex-interacting drugs displayed low selectivity to the targeted G-quadruplex structure. This low selectivity could cause unexpected effects that are usually reasons to halt the drug development process. In this review, we address the recent research on synthetic G4 DNA-interacting ligands that allow targeting of selected G4s as an approach toward the discovery of highly effective anticancer drugs.

scholarly journals Overlapping but distinct: a new model for G-quadruplex biochemical specificity

2021 ◽  
Author(s):  
Martin Volek ◽  
Sofia Kolesnikova ◽  
Katerina Svehlova ◽  
Pavel Srb ◽  
Ráchel Sgallová ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Drug Design ◽  
Solution Structure ◽  
Biochemical Data ◽  
Biological Regulation ◽  
New Model ◽  
G Quadruplex ◽  
Range Of Functions ◽  
Nucleic Acid Structures ◽  
Sequence Requirements

Abstract G-quadruplexes are noncanonical nucleic acid structures formed by stacked guanine tetrads. They are capable of a range of functions and thought to play widespread biological roles. This diversity raises an important question: what determines the biochemical specificity of G-quadruplex structures? The answer is particularly important from the perspective of biological regulation because genomes can contain hundreds of thousands of G-quadruplexes with a range of functions. Here we analyze the specificity of each sequence in a 496-member library of variants of a reference G-quadruplex with respect to five functions. Our analysis shows that the sequence requirements of G-quadruplexes with these functions are different from one another, with some mutations altering biochemical specificity by orders of magnitude. Mutations in tetrads have larger effects than mutations in loops, and changes in specificity are correlated with changes in multimeric state. To complement our biochemical data we determined the solution structure of a monomeric G-quadruplex from the library. The stacked and accessible tetrads rationalize why monomers tend to promote a model peroxidase reaction and generate fluorescence. Our experiments support a model in which the sequence requirements of G-quadruplexes with different functions are overlapping but distinct. This has implications for biological regulation, bioinformatics, and drug design.

Design and Synthesis of an Expanded Porphyrin That Has Selectivity for the c-MYC G-Quadruplex Structure

2005 ◽  
Vol 127 (9) ◽  
pp. 2944-2959 ◽  
Author(s):  
Jeyaprakashnarayanan Seenisamy ◽  
Sridevi Bashyam ◽  
Vijay Gokhale ◽  
Hariprasad Vankayalapati ◽  
Daekyu Sun ◽  
...  
Keyword(s):  
Design And Synthesis ◽  
Quadruplex Structure ◽  
G Quadruplex ◽  
Expanded Porphyrin
Sign in / Sign up

Export Citation Format

Share Document