scholarly journals Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Juliane Weiner ◽  
Mathias Kranz ◽  
Nora Klöting ◽  
Anne Kunath ◽  
Karen Steinhoff ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Thyroid Hormone ◽  
Brown Adipose Tissue ◽  
Adipose Tissues ◽  
Brown Adipose ◽  
Hormone Status ◽  
Brown Adipose Tissue Activity

scholarly journals Variable Cold-Induced Brown Adipose Tissue Response to Thyroid Hormone Status

Thyroid ◽  
2017 ◽  
Vol 27 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Alina Gavrila ◽  
Per-Olof Hasselgren ◽  
Allison Glasgow ◽  
Ashley N. Doyle ◽  
Alice J. Lee ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Thyroid Hormone ◽  
Brown Adipose Tissue ◽  
Tissue Response ◽  
Brown Adipose ◽  
Hormone Status

Thyroid-stimulating hormone receptor in brown adipose tissue is involved in the regulation of thermogenesis

2008 ◽  
Vol 295 (2) ◽  
pp. E514-E518 ◽  
Author(s):  
Toyoshi Endo ◽  
Tetsuro Kobayashi
Keyword(s):  
Adipose Tissue ◽  
Thyroid Hormone ◽  
Brown Adipose Tissue ◽  
Rectal Temperature ◽  
Hormone Receptor ◽  
Uncoupling Protein ◽  
Thyroid Stimulating Hormone ◽  
Adipose Tissues ◽  
Brown Adipose ◽  
Stimulating Hormone

C.RF- Tshrhyt/hyt mice have a mutated thyroid-stimulating hormone receptor (TSHR), and, without thyroid hormone supplementation, these mice develop severe hypothyroidism. When hypothyroid Tshrhyt/hyt mice were exposed to cold (4°C), rectal temperature rapidly dropped to 23.9 ± 0.40°C at 90 min, whereas the wild-type mice temperatures were 37.0 ± 0.15°C. When we carried out functional rat TSHR gene transfer in the brown adipose tissues by plasmid injection combined with electroporation, there was no effect on the serum levels of thyroxine, although rectal temperature of the mice transfected with pcDNA3.1/Zeo-rat TSHR 90 min after cold exposure remained at 34.6 ± 0.34°C, which was significantly higher than that of Tshrhyt/hyt mice. Transfection of TSHR cDNA increased mRNA and protein levels of uncoupling protein-1 (UCP-1) in brown adipose tissues, and the weight ratio of brown adipose tissue to overall body weight also increased. Exogenous thyroid hormone supplementation to Tshrhyt/hyt mice restored rectal temperature 90 min after exposure to cold (36.8 ± 0.10°C). These results indicate that not only thyroid hormone but also thyroid-stimulating hormone (TSH)/TSHR are involved in the expression mechanism of UCP-1 in mouse brown adipose tissue. TSH stimulates thermogenesis and functions to protect a further decrease in body temperature in the hypothyroid state.

scholarly journals Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications

2016 ◽  
Vol 2016 ◽  
pp. 1-15 ◽  
Author(s):  
Almudena Gómez-Hernández ◽  
Nuria Beneit ◽  
Sabela Díaz-Castroverde ◽  
Óscar Escribano
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Vascular Complications ◽  
New Drugs ◽  
Adipose Tissues ◽  
Brown Adipose ◽  
Brown Adipose Tissue Activity ◽  
Atherosclerotic Process ◽  
New Treatments

This review focuses on the contribution of white, brown, and perivascular adipose tissues to the pathophysiology of obesity and its associated metabolic and vascular complications. Weight gain in obesity generates excess of fat, usually visceral fat, and activates the inflammatory response in the adipocytes and then in other tissues such as liver. Therefore, low systemic inflammation responsible for insulin resistance contributes to atherosclerotic process. Furthermore, an inverse relationship between body mass index and brown adipose tissue activity has been described. For these reasons, in recent years, in order to combat obesity and its related complications, as a complement to conventional treatments, a new insight is focusing on the role of the thermogenic function of brown and perivascular adipose tissues as a promising therapy in humans. These lines of knowledge are focused on the design of new drugs, or other approaches, in order to increase the mass and/or activity of brown adipose tissue or the browning process of beige cells from white adipose tissue. These new treatments may contribute not only to reduce obesity but also to prevent highly prevalent complications such as type 2 diabetes and other vascular alterations, such as hypertension or atherosclerosis.

Short Dietary Intervention with Olive Oil Increases Brown Adipose Tissue Activity in Lean But Not Overweight/Obese Subjects

2020 ◽  
Author(s):  
Milena Monfort-Pires ◽  
Muuez U-Din ◽  
Guilherme A. Nogueira ◽  
Juliana de Almeida-Faria ◽  
Davi Sidarta-Oliveira ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Olive Oil ◽  
Dietary Intervention ◽  
Brown Adipose ◽  
Obese Subjects ◽  
Brown Adipose Tissue Activity

scholarly journals Reduced Expression of Urokinase Plasminogen Activator in Brown Adipose Tissue of Obese Mouse Models

2021 ◽  
Vol 22 (7) ◽  
pp. 3407
Author(s):  
Chung-Ze Wu ◽  
Li-Chien Chang ◽  
Chao-Wen Cheng ◽  
Te-Chao Fang ◽  
Yuh-Feng Lin ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glomerular Filtration Rate ◽  
Brown Adipose Tissue ◽  
Glomerular Filtration ◽  
Plasminogen Activator ◽  
Mouse Models ◽  
Filtration Rate ◽  
Obese Mouse ◽  
Adipose Tissues ◽  
Brown Adipose

In recent decades, the obesity epidemic has resulted in morbidity and mortality rates increasing globally. In this study, using obese mouse models, we investigated the relationship among urokinase plasminogen activator (uPA), metabolic disorders, glomerular filtration rate, and adipose tissues. Two groups, each comprised of C57BL/6J and BALB/c male mice, were fed a chow diet (CD) and a high fat diet (HFD), respectively. Within the two HFD groups, half of each group were euthanized at 8 weeks (W8) or 16 weeks (W16). Blood, urine and adipose tissues were collected and harvested for evaluation of the effects of obesity. In both mouse models, triglyceride with insulin resistance and body weight increased with duration when fed a HFD in comparison to those in the groups on a CD. In both C57BL/6J and BALB/c HFD mice, levels of serum uPA initially increased significantly in the W8 group, and then the increment decreased in the W16 group. The glomerular filtration rate declined in both HFD groups. The expression of uPA significantly decreased in brown adipose tissue (BAT), but not in white adipose tissue, when compared with that in the CD group. The results suggest a decline in the expression of uPA in BAT in obese m models as the serum uPA increases. There is possibly an association with BAT fibrosis and dysfunction, which may need further study.

Reduced brown adipose tissue activity during cold exposure is a metabolic feature of the human thrifty phenotype

Metabolism ◽  
2021 ◽  
Vol 117 ◽  
pp. 154709 ◽  
Author(s):  
Tim Hollstein ◽  
Karyne Vinales ◽  
Kong Y. Chen ◽  
Aaron M. Cypess ◽  
Alessio Basolo ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cold Exposure ◽  
Thrifty Phenotype ◽  
Brown Adipose ◽  
Metabolic Feature ◽  
Brown Adipose Tissue Activity

scholarly journals Modulation of musculoskeletal hyperalgesia by brown adipose tissue activity in mice

Pain ◽  
2016 ◽  
Vol 157 (11) ◽  
pp. 2561-2570 ◽  
Author(s):  
Elizabeth M. Goudie-DeAngelis ◽  
Ramy E. Abdelhamid ◽  
Myra G. Nunez ◽  
Casey L. Kissel ◽  
Katalin J. Kovács ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Brown Adipose ◽  
Brown Adipose Tissue Activity

scholarly journals Correction: Thyroid Hormone Activates Brown Adipose Tissue and Increases Non-Shivering Thermogenesis—A Cohort Study in a Group of Thyroid Carcinoma Patients

PLoS ONE ◽  
2018 ◽  
Vol 13 (12) ◽  
pp. e0209225
Author(s):  
Evie P. M. Broeders ◽  
Guy H. E. J. Vijgen ◽  
Bas Havekes ◽  
Nicole D. Bouvy ◽  
Felix M. Mottaghy ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Cohort Study ◽  
Thyroid Hormone ◽  
Thyroid Carcinoma ◽  
Brown Adipose Tissue ◽  
Brown Adipose ◽  
Shivering Thermogenesis
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