scholarly journals Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Aphroditi A. Mamaligas ◽  
Yuan Cai ◽  
Christopher P. Ford
Keyword(s):  
Opioid Receptor ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Striatal Dopamine ◽  
Receptor Regulation ◽  
Dopamine D2

scholarly journals Effect of Zishenpingchan Granule on Neurobehavioral Manifestations and the Activity and Gene Expression of Striatal Dopamine D1 and D2 Receptors of Rats with Levodopa-Induced Dyskinesias

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Qing Ye ◽  
Xiao-Lei Yuan ◽  
Jie Zhou ◽  
Can-xing Yuan ◽  
Xu-ming Yang
Keyword(s):  
Gene Expression ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
D2 Receptors ◽  
Striatal Dopamine ◽  
Control Group ◽  
Indirect Pathway ◽  
Dopamine D2 ◽  
D1 And D2 Receptors ◽  
Neurobehavioral Manifestations

This study was performed to observe the effects of Zishenpingchan granule on neurobehavioral manifestations and the activity and gene expression of striatal dopamine D1 and D2 receptors of rats with levodopa-induced dyskinesias (LID). We established normal control group, LID model group, and TCM intervention group. Each group received treatment for 4 weeks. Artificial neural network (ANN) was applied to excavate the main factor influencing variation in neurobehavioral manifestations of rats with LID. The results showed that overactivation in direct pathway mediated by dopamine D1 receptor and overinhibition in indirect pathway mediated by dopamine D2 receptor may be the main mechanism of LID. TCM increased the efficacy time of LD to ameliorate LID symptoms effectively mainly by upregulating dopamine D2 receptor gene expression.

scholarly journals Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D2 Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor

Biomolecules ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 368 ◽  
Author(s):  
Vasudevan ◽  
Borroto-Escuela ◽  
Huysentruyt ◽  
Fuxe ◽  
Saini ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Opioid Receptor ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Mu Opioid Receptor ◽  
Potential Threat ◽  
Mu Opioid ◽  
Dopamine D2

The interplay between the dopamine (DA) and opioid systems in the brain is known to modulate the additive effects of substances of abuse. On one hand, opioids serve mankind by their analgesic properties, which are mediated via the mu opioid receptor (MOR), a Class A G protein-coupled receptor (GPCR), but on the other hand, they pose a potential threat by causing undesired side effects such as tolerance and dependence, for which the exact molecular mechanism is still unknown. Using human embryonic kidney 293T (HEK 293T) and HeLa cells transfected with MOR and the dopamine D2 receptor (D2R), we demonstrate that these receptors heterodimerize, using an array of biochemical and biophysical techniques such as coimmunoprecipitation (co-IP), bioluminescence resonance energy transfer (BRET1), Fӧrster resonance energy transfer (FRET), and functional complementation of a split luciferase. Furthermore, live cell imaging revealed that D2LR, when coexpressed with MOR, slowed down internalization of MOR, following activation with the MOR agonist [D-Ala2, N-MePhe4, Gly-ol]-enkephalin (DAMGO).

Striatal dopamine D2 receptor occupancy in patients treated with olanzapine

1998 ◽  
Vol 29 (1-2) ◽  
pp. 166 ◽  
Author(s):  
T.J. Raedler ◽  
M.B. Knable ◽  
T. Lafargue ◽  
D. Pickar ◽  
D.R. Weinberger
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Occupancy ◽  
Striatal Dopamine ◽  
Dopamine D2 ◽  
Dopamine D2 Receptor Occupancy

scholarly journals Cannabinoid-1 receptor antagonist rimonabant (SR141716) increases striatal dopamine D2 receptor availability

2011 ◽  
Vol 18 (6) ◽  
pp. 908-911 ◽  
Author(s):  
Cleo L. Crunelle ◽  
Elsmarieke van de Giessen ◽  
Sybille Schulz ◽  
Louk J. M. J. Vanderschuren ◽  
Kora de Bruin ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Striatal Dopamine ◽  
Dopamine D2 ◽  
Cannabinoid 1 Receptor
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