scholarly journals CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yanyan Zhang ◽  
Mallorie Dépond ◽  
Liang He ◽  
Adlen Foudi ◽  
Edward Owusu Kwarteng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Cell Exhaustion ◽  
Selective Protection

scholarly journals An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion

2018 ◽  
Vol 22 (6) ◽  
pp. 879-892.e6 ◽  
Author(s):  
Christian Baumgartner ◽  
Stefanie Toifl ◽  
Matthias Farlik ◽  
Florian Halbritter ◽  
Ruth Scheicher ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Feedback Mechanism ◽  
Hematopoietic Stem ◽  
Cell Exhaustion

scholarly journals FOXO activity adaptation safeguards the hematopoietic stem cell compartment in hyperglycemia

2020 ◽  
Vol 4 (21) ◽  
pp. 5512-5526
Author(s):  
Vinothini Govindarajah ◽  
Jung-Mi Lee ◽  
Michael Solomon ◽  
Bryan Goddard ◽  
Ramesh Nayak ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Cell ◽  
Stress Response ◽  
Hematopoietic Stem Cell ◽  
Adaptive Strategy ◽  
Oxidative Stress Response ◽  
Obese Mice ◽  
Hematopoietic Stem ◽  
Metabolic Stresses

Abstract Hematopoietic stem cell (HSC) activity is tightly controlled to ensure the integrity of the hematopoietic system during the organism’s lifetime. How the HSC compartment maintains its long-term fitness in conditions of chronic stresses associated with systemic metabolic disorders is poorly understood. In this study, we show that obesity functionally affects the long-term function of the most immature engrafting HSC subpopulation. We link this altered regenerative activity to the oxidative stress and the aberrant constitutive activation of the AKT signaling pathway that characterized the obese environment. In contrast, we found minor disruptions of the HSC function in obese mice at steady state, suggesting that active mechanisms could protect the HSC compartment from its disturbed environment. Consistent with this idea, we found that FOXO proteins in HSCs isolated from obese mice become insensitive to their normal upstream regulators such as AKT, even during intense oxidative stress. We established that hyperglycemia, a key condition associated with obesity, is directly responsible for the alteration of the AKT-FOXO axis in HSCs and their abnormal oxidative stress response. As a consequence, we observed that HSCs isolated from a hyperglycemic environment display enhanced resistance to oxidative stress and DNA damage. Altogether, these results indicate that chronic metabolic stresses associated with obesity and/or hyperglycemia affect the wiring of the HSCs and modify their oxidative stress response. These data suggest that the uncoupling of FOXO from its environmental regulators could be a key adaptive strategy that promotes the survival of the HSC compartment in obesity.

Genetic regulation of hematopoietic stem cell exhaustion during development and growth

2005 ◽  
Vol 33 (2) ◽  
pp. 243-250 ◽  
Author(s):  
Rong Yuan ◽  
C.M. Astle ◽  
Jichun Chen ◽  
David E. Harrison
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Genetic Regulation ◽  
Hematopoietic Stem ◽  
Cell Exhaustion

Inflammatory markers, oxidative stress, and antioxidant capacity in healthy allo-HSCT donors during hematopoietic stem cell mobilization

2014 ◽  
Vol 30 (4) ◽  
pp. 197-203 ◽  
Author(s):  
Çiğdem İlhan ◽  
Elif Suyanı ◽  
Gülsan Türköz Sucak ◽  
Özge Tuğçe Paşaoğlu ◽  
Şahika Zeynep Akı ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Cell ◽  
Antioxidant Capacity ◽  
Hematopoietic Stem Cell ◽  
Inflammatory Markers ◽  
Stem Cell Mobilization ◽  
Hematopoietic Stem ◽  
Hematopoietic Stem Cell Mobilization ◽  
Cell Mobilization
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