scholarly journals Modulation of light-driven arousal by LIM-homeodomain transcription factor Apterous in large PDF-positive lateral neurons of the Drosophila brain

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Naoto Shimada ◽  
Show Inami ◽  
Shoma Sato ◽  
Toshihiro Kitamoto ◽  
Takaomi Sakai
Keyword(s):  
Transcription Factor ◽  
Homeodomain Transcription Factor ◽  
Drosophila Brain ◽  
Lim Homeodomain ◽  
Lateral Neurons

scholarly journals The LIM-homeodomain transcription factor Islet2a promotes angioblast migration

2016 ◽  
Vol 414 (2) ◽  
pp. 181-192 ◽  
Author(s):  
Ryan E. Lamont ◽  
Chang.-Yi. Wu ◽  
Jae.-Ryeon. Ryu ◽  
Wendy Vu ◽  
Paniz Davari ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Homeodomain Transcription Factor ◽  
Lim Homeodomain

Expression and function of the LIM-homeodomain transcription factor Islet-1 in the developing and mature vertebrate retina

2015 ◽  
Vol 138 ◽  
pp. 22-31 ◽  
Author(s):  
Ruth Bejarano-Escobar ◽  
Guadalupe Álvarez-Hernán ◽  
Ruth Morona ◽  
Agustín González ◽  
Gervasio Martín-Partido ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Homeodomain Transcription Factor ◽  
Vertebrate Retina ◽  
Islet 1 ◽  
And Function ◽  
Lim Homeodomain

scholarly journals The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes

2002 ◽  
Vol 109 (8) ◽  
pp. 1073-1082 ◽  
Author(s):  
Claudia Rohr ◽  
Jürgen Prestel ◽  
Laurence Heidet ◽  
Hiltraud Hosser ◽  
Wilhelm Kriz ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Crucial Role ◽  
Homeodomain Transcription Factor ◽  
Lim Homeodomain

scholarly journals Anti-osteogenic function of a LIM-homeodomain transcription factor LMX1B is essential to early patterning of the calvaria

2018 ◽  
Vol 443 (2) ◽  
pp. 103-116 ◽  
Author(s):  
Jeffry M. Cesario ◽  
André Landin Malt ◽  
Jong Uk Chung ◽  
Michael P. Khairallah ◽  
Krishnakali Dasgupta ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Homeodomain Transcription Factor ◽  
Lim Homeodomain

Cell type-specific regulation of the Drosophila FMRF-NH2 neuropeptide gene by Apterous, a LIM homeodomain transcription factor

Development ◽  
1998 ◽  
Vol 125 (23) ◽  
pp. 4757-4765 ◽  
Author(s):  
R.J. Benveniste ◽  
S. Thor ◽  
J.B. Thomas ◽  
P.H. Taghert
Keyword(s):  
Transcription Factor ◽  
Morphological Differentiation ◽  
Cell Types ◽  
Neuroendocrine Cells ◽  
Cell Type ◽  
Homeodomain Transcription Factor ◽  
Neuron Survival ◽  
Cell Type Specific ◽  
Specific Regulation ◽  
Lim Homeodomain

We describe the direct and cell-specific regulation of the Drosophila FMRFa neuropeptide gene by Apterous, a LIM homeodomain transcription factor. dFMRFa and Apterous are expressed in partially overlapping subsets of neurons, including two of the seventeen dFMRFa cell types, the Tv neuroendocrine cells and the SP2 interneurons. Apterous contributes to the initiation of dFMRFa expression in Tv neurons, but not in those dFMRFa neurons that do not express Apterous. Apterous is not required for Tv neuron survival or morphological differentiation. Apterous contributes to the maintenance of dFMRFa expression by postembryonic Tv neurons, although the strength of its regulation is diminished. Apterous regulation of dFMRFa expression includes direct mechanisms, although ectopic Apterous does not induce ectopic dFMRFa. These findings show that, for a subset of neurons that share a common neurotransmitter phenotype, the Apterous LIM homeoprotein helps define neurotransmitter expression with very limited effects on other aspects of differentiation.

scholarly journals LIM-Homeodomain Transcription Factor Isl-1 Mediates Kisspeptin's Effect on Insulin Secretion in Mice

2014 ◽  
Vol 28 (8) ◽  
pp. 1276-1290 ◽  
Author(s):  
Juan Chen ◽  
Rui Fu ◽  
Yan Cui ◽  
Jirong Pan ◽  
Yushan Li ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Insulin Secretion ◽  
Pancreatic Islet ◽  
Islet Cells ◽  
Direct Action ◽  
Janus Kinase ◽  
Homeodomain Transcription Factor ◽  
Lim Homeodomain

Kisspeptin and the G protein-coupled receptor 54 (GPR54) are highly abundant in the pancreas. In addition, circulating kisspeptin directly influences insulin secretion through GPR54. However, the mechanisms by which kisspeptin affects insulin release are unclear. The LIM-homeodomain transcription factor, Isl-1, is expressed in all pancreatic islet cells and is involved in regulating both islet development and insulin secretion. We therefore investigated potential interactions between kisspeptin and Isl-1. Our results demonstrate that Isl-1 and GPR54 are coexpressed in mouse pancreatic islet β-cells and NIT cells. Both in vitro and in vivo results demonstrate that kisspeptin-54 (KISS-54) inhibits Isl-1 expression and insulin secretion and both the in vivo and in vitro effects of KISS-54 on insulin gene expression and secretion are abolished when an Isl-1-inducible knockout model is used. Moreover, our results demonstrate that the direct action of KISS-54 on insulin secretion is mediated by Isl-1. Our results further show that KISS-54 influences Isl-1 expression and insulin secretion through the protein kinase C-ERK1/2 pathway. Conversely, insulin has a feedback loop via the Janus kinase-phosphatidylinositol 3-kinase pathway regulating kisspeptin expression and secretion. These findings are important in understanding mechanisms of insulin secretion and metabolism in diabetes.

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