scholarly journals How knowledge of the gastrointestinal absorption of elements could be used to predict transfer to milk

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Brenda J. Howard ◽  
Claire Wells ◽  
Catherine L. Barnett ◽  
Steve C. Sheppard
Keyword(s):  
Gastrointestinal Absorption ◽  
Transfer To Milk

„IN SILICO“ PREDICTION OF PHARMACOKINETIC PROPERTIES AND DRUGLIKENESS OF NOVEL THIOUREA DERIVATIVES OF NAPROXEN

2021 ◽  
Author(s):  
Nikola V. Nedeljković ◽  
◽  
Vladimir D. Dobričić ◽  
Marina Ž. Mijajlović ◽  
Gordana P. Radić ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Aromatic Amines ◽  
Gastrointestinal Absorption ◽  
Skin Permeability ◽  
Thiourea Derivatives ◽  
Barrier Permeability ◽  
Brain Barrier Permeability ◽  
Pharmacokinetic Properties ◽  
Inhibitory Potential ◽  
Derivatives Of

Masking the carboxyl group of naproxen with other functional groups may be a promising strategy to decrease its gastrointestinal toxicity. Thiourea moiety has been described as an important pharmacophore in a variety of pharmacologically active compounds, including anti-inflammatory, antiviral, anticancer, hypoglycemic and antimicrobial agents. Our research group has previously designed twenty novel thiourea derivatives of naproxen, containing amino acids (glycine, L-alanine, β-alanine, L-valine and L-phenylalanine – compounds 1,2,3,4 and 5, respectively), their methyl (6–10) and ethyl esters (11–15), as well as aromatic amines (16–20). Pharmacokinetic properties and druglikeness of these compounds were predicted using SwissADME web tool (http://www.swissadme.ch/). Predicted pharmacokinetic properties include potential for gastrointestinal absorption, blood-brain barrier permeability, skin permeability, transport mediated by P-glycoproteins and enzyme inhibitory potential. Druglikeness was evaluated using Lipinski’s, Ghose’s, Veber’s, Egan’s and Muegge’s rules, as well as on the basis of bioavailability score. All tested compounds had high-predicted gastrointestinal absorption and low blood-brain barrier permeability. Also, derivatives 2, 4, 7, 9, 10, 12, 14, 15 and 18 were predicted to be substrates for P-glycoprotein. Derivatives with aromatic amines (16–20) showed inhibitory potential against all tested CYP isoforms. Derivative 19 had the highest, while derivative 13 demonstrated the lowest predicted skin permeability. Finally, derivatives 1–12, except 5 and 10, have druglike structures, since they obey to all imposed rules.

The Treatment of Iron-deficiency Anemia—Palatable but Ineffective Iron Medication

PEDIATRICS ◽  
1963 ◽  
Vol 31 (6) ◽  
pp. 1041-1044
Author(s):  
LOUIS K DIAMOND ◽  
J. LAWRENCE NAIMAN ◽  
DONALD M. ALLEN ◽  
FRANK A. OSKI,
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Ferrous Sulfate ◽  
Oral Iron ◽  
Gastrointestinal Absorption ◽  
Deficiency Anemia ◽  
Therapeutic Effects ◽  
Rapid Rise ◽  
Carbohydrate Complex ◽  
Therapeutic Results

Experience with a new oral iron-carbohydrate complex (Jefron) in the treatment of iron-deficiency anemia shows that the therapeutic results are inferior to those obtainable with ferrous sulfate. Many children showed no response after months of treatment with this drug and when subsequently placed on ferrous sulfate therapy showed a rapid rise in hemoglobin to normal levels. Preliminary studies suggest that poor gastrointestinal absorption may be a factor in the inadequate therapeutic effects.

scholarly journals Deposition of Fallout Cesium 137 on Forage and Transfer to Milk

1966 ◽  
Vol 81 (7) ◽  
pp. 639 ◽  
Author(s):  
Gerald M. Ward ◽  
James E. Johnson ◽  
Daniel W. Wilson
Keyword(s):  
Cesium 137 ◽  
Transfer To Milk

Gastrointestinal iron and cobalt absorption and iron status in young rats and guinea pigs

1995 ◽  
Vol 14 (12) ◽  
pp. 949-954 ◽  
Author(s):  
Gpl Naylor ◽  
JD Harrison
Keyword(s):  
Guinea Pig ◽  
Guinea Pigs ◽  
Iron Status ◽  
Age Groups ◽  
Gastrointestinal Absorption ◽  
Whole Body ◽  
Suckling Period ◽  
Young Rats ◽  
Body Retention ◽  
Different Ages

The gastrointestinal absorption of Fe and Co by rats and guinea pigs of different ages was measured by comparing the whole-body retention of 59Fe and 57Co after oral and intraperitoneal administrations. The age-groups studied included newborn, weanlings and adults. The absorption of both Fe and Co decreased markedly with age in both rats and guinea pigs. In the rat, absorption remained ele vated during the suckling period, while in the guinea pig absorption decreased markedly during suckling. In both species, Fe and Co absorption were similar, and remained elevated above adult values for some time after weaning. The generally greater absorption of Fe and Co by rats than by guinea pigs and the longer duration of maximal absorp tion in the rats may have involved differences in Fe status in the two species and differences in the timing of gut mat uration.

Synthesis and Evaluation of Compounds That Facilitate the Gastrointestinal Absorption of Heparin

1998 ◽  
Vol 41 (7) ◽  
pp. 1163-1171 ◽  
Author(s):  
Andrea Leone-Bay ◽  
Duncan R. Paton ◽  
John Freeman ◽  
Christine Lercara ◽  
Doris O'Toole ◽  
...  
Keyword(s):  
Gastrointestinal Absorption
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