scholarly journals Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Mohamed A. Shehata ◽  
Anne C. Nøhr ◽  
Delphine Lissa ◽  
Christoph Bisig ◽  
Vignir Isberg ◽  
...  
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptor ◽  
Structure Activity Relationships ◽  
Common Structure ◽  
Structure Activity ◽  
G Protein Coupled

Structure-activity relationships of agonists for the orphan G protein-coupled receptor GPR27

2021 ◽  
pp. 113777
Author(s):  
Thanigaimalai Pillaiyar ◽  
Francesca Rosato ◽  
Monika Wozniak ◽  
Jeremy Blavier ◽  
Maëlle Charles ◽  
...  
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptor ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
G Protein Coupled

scholarly journals Identification of the first surrogate agonists for the G protein-coupled receptor GPR132

RSC Advances ◽  
2015 ◽  
Vol 5 (60) ◽  
pp. 48551-48557 ◽  
Author(s):  
Mohamed A. Shehata ◽  
Hanna Belcik Christensen ◽  
Vignir Isberg ◽  
Daniel Sejer Pedersen ◽  
Andreas Bender ◽  
...  
Keyword(s):  
G Protein ◽  
Binding Mode ◽  
Orphan Receptor ◽  
G Protein Coupled Receptor ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
G Protein Coupled

We report the first pharmacological tool agonist for in vitro characterization of the orphan receptor GPR132, preliminary structure–activity relationships based on 32 analogs and a suggested binding mode from docking.

Structure-activity relationships of imidazothiazinones and analogs as antagonists of the cannabinoid-activated orphan G protein-coupled receptor GPR18

2018 ◽  
Vol 155 ◽  
pp. 381-397 ◽  
Author(s):  
Clara T. Schoeder ◽  
Maria Kaleta ◽  
Andhika B. Mahardhika ◽  
Agnieszka Olejarz-Maciej ◽  
Dorota Łażewska ◽  
...  
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptor ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
G Protein Coupled

Structure–activity relationship of novel macrocyclic biased apelin receptor agonists

2017 ◽  
Vol 15 (2) ◽  
pp. 449-458 ◽  
Author(s):  
Alexandre Murza ◽  
Xavier Sainsily ◽  
Jérôme Côté ◽  
Laurent Bruneau-Cossette ◽  
Élie Besserer-Offroy ◽  
...  
Keyword(s):  
G Protein ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
G Protein Coupled Receptor ◽  
Endogenous Ligand ◽  
Structure Activity ◽  
Apelin Receptor ◽  
Relationship Of ◽  
G Protein Coupled ◽  
Cardiovascular Functions

Apelin is the endogenous ligand for the G protein-coupled receptor APJ and exerts a key role in regulating cardiovascular functions.

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