Characterization of the Annonaceous acetogenin, annonacinone, a natural product inhibitor of plasminogen activator inhibitor-1

Stéphane Pautus; Mouad Alami; Fréderic Adam; Guillaume Bernadat; Daniel A. Lawrence; Allan De Carvalho; Gilles Ferry; Alain Rupin; Abdallah Hamze; Pierre Champy; Natacha Bonneau; Philippe Gloanec; Jean-Louis Peglion; Jean-Daniel Brion; Elsa P. Bianchini; Delphine Borgel

doi:10.1038/srep36462

Characterization of the Annonaceous acetogenin, annonacinone, a natural product inhibitor of plasminogen activator inhibitor-1

Scientific Reports ◽

10.1038/srep36462 ◽

2016 ◽

Vol 6 (1) ◽

Cited By ~ 6

Author(s):

Stéphane Pautus ◽

Mouad Alami ◽

Fréderic Adam ◽

Guillaume Bernadat ◽

Daniel A. Lawrence ◽

...

Keyword(s):

Natural Product ◽

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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Faculty Opinions recommendation of Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1019931.226492 ◽

2004 ◽

Author(s):

Thomas W von Geldern

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Design Synthesis ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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Isolation and characterization of plasminogen activator inhibitor 1 (PAI- 1)mutant( e350g, e351k)

Fibrinolysis and Proteolysis ◽

10.1016/0268-9499(94)90577-0 ◽

1994 ◽

Vol 8 ◽

pp. 105

Author(s):

M.-H. Hu ◽

G.-C. Sui

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Isolation And Characterization ◽

Activator Inhibitor ◽

Pai 1

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Characterization of common neoantigenic epitopes generated in plasminogen activator inhibitor-1 after cleavage of the reactive center loop or after complex formation with various serine proteinases

FEBS Letters ◽

10.1016/0014-5793(95)01289-0 ◽

1995 ◽

Vol 376 (3) ◽

pp. 243-246 ◽

Cited By ~ 20

Author(s):

Sophie Debrock ◽

Paul J. Declerck

Keyword(s):

Complex Formation ◽

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Serine Proteinases ◽

Plasminogen Activator Inhibitor 1 ◽

Reactive Center Loop ◽

Reactive Center ◽

Activator Inhibitor

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A Novel Antithrombotic Role for High Molecular Weight Kininogen as Inhibitor of Plasminogen Activator Inhibitor-1 Function

Journal of Biological Chemistry ◽

10.1074/jbc.m204010200 ◽

2002 ◽

Vol 277 (36) ◽

pp. 32677-32682 ◽

Cited By ~ 14

Author(s):

Triantafyllos Chavakis ◽

Robin A. Pixley ◽

Irma Isordia-Salas ◽

Robert W. Colman ◽

Klaus T. Preissner

Keyword(s):

Molecular Weight ◽

High Molecular Weight ◽

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

High Molecular Weight Kininogen ◽

Plasminogen Activator Inhibitor 1 ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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Construction and characterization of plasminogen activator inhibitor-1 mutants in which part of the active site loop is deleted

Fibrinolysis and Proteolysis ◽

10.1016/s0268-9499(97)80111-7 ◽

1997 ◽

Vol 11 (5-6) ◽

pp. 265-271 ◽

Cited By ~ 1

Author(s):

A. Gils ◽

I. Knockaert ◽

P.J. Declerck

Keyword(s):

Plasminogen Activator ◽

Active Site ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Activator Inhibitor

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197 Characterization of the binding of a pentapeptide to plasminogen activator inhibitor -1

Fibrinolysis and Proteolysis ◽

10.1016/s0268-9499(98)80226-9 ◽

1998 ◽

Vol 12 ◽

pp. 72

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Activator Inhibitor

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A novel inhibitor of plasminogen activator inhibitor-1, T-686, modulates development of atherosclerosis in vivo in rabbits

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(96)80451-7 ◽

1996 ◽

Vol 27 (2) ◽

pp. 64 ◽

Cited By ~ 1

Author(s):

Boris Vinogradsky ◽

Stephen P. Bell ◽

Hitoshi Okada ◽

Amy S. Guala ◽

Dagnija Thornton ◽

...

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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A specific inhibitor of plasminogen activator inhibitor-1 suppresses rat autoimmune myocarditis

Expert Opinion on Therapeutic Targets ◽

10.1517/14728222.12.11.1313 ◽

2008 ◽

Vol 12 (11) ◽

pp. 1313-1320 ◽

Cited By ~ 11

Author(s):

Jun-ichi Suzuki ◽

Masahito Ogawa ◽

Susumu Muto ◽

Akiko Itai ◽

Mitsuaki Isobe

Keyword(s):

Plasminogen Activator ◽

Specific Inhibitor ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Autoimmune Myocarditis ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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PAI-039, An Inhibitor Of Plasminogen Activator Inhibitor-1, Ameliorates Lung Injury Induced By Bleomycin

10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3706 ◽

2012 ◽

Author(s):

Jie Liu ◽

Xun Wang ◽

Qin Wang ◽

Chunxue Bai ◽

Yuanlin Song

Keyword(s):

Lung Injury ◽

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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111 Characterization of plasminogen-activator inhibitor 1 (PAI-1) binding phages isolated from a phage peptide display library

Fibrinolysis and Proteolysis ◽

10.1016/s0268-9499(96)80198-6 ◽

1996 ◽

Vol 10 ◽

pp. 35

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Peptide Display ◽

Activator Inhibitor ◽

Pai 1 ◽

Peptide Display Library

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