scholarly journals X-Ray based Lung Function measurement–a sensitive technique to quantify lung function in allergic airway inflammation mouse models

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
C. Dullin ◽  
M. A. Markus ◽  
E. Larsson ◽  
G. Tromba ◽  
S. Hülsmann ◽  
...  
Keyword(s):  
Lung Function ◽  
Airway Inflammation ◽  
Mouse Models ◽  
Allergic Airway Inflammation ◽  
Function Measurement ◽  
Sensitive Technique ◽  
X Ray ◽  
Lung Function Measurement

scholarly journals X-ray-based lung function measurement reveals persistent loss of lung tissue elasticity in mice recovered from allergic airway inflammation

2017 ◽  
Vol 313 (5) ◽  
pp. L763-L771 ◽  
Author(s):  
M. Andrea Markus ◽  
Sergej Borowik ◽  
Marius Reichardt ◽  
Giuliana Tromba ◽  
Frauke Alves ◽  
...  
Keyword(s):  
Lung Function ◽  
Airway Inflammation ◽  
Mouse Models ◽  
Recovery Period ◽  
Allergic Airway Inflammation ◽  
Elastic Fibers ◽  
Chronic Asthma ◽  
Tissue Elasticity ◽  
X Ray

Chronic asthma patients experience difficulties even years after the inciting allergen. Although studies in small animal asthma models have enormously advanced progress in uncovering the mechanisms of inception and development of the disease, little is known about the processes involved in the persistence of asthma symptoms in the absence of allergen exposure. Long-term asthma mouse models have so far been scarce or not been able to reproduce the findings in patients. Here we used a common ovalbumin-induced acute allergic airway inflammation mouse model to study lung function and remodeling after a 4-mo recovery period. We show by X-ray-based lung function measurements that the recovered mice continue to show impaired lung function by displaying significant air trapping compared with controls. High-resolution synchrotron phase-contrast computed tomography of structural alterations and diaphragm motion analysis suggest that these changes in pulmonary function are the result of a pronounced loss in lung elasticity. Histology of lung sections confirmed that this is most likely caused by a decrease in elastic fibers, indicating that remodeling can develop or persist independent of acute inflammation and is closely related to a loss in lung function. Our findings demonstrate that this X-ray-based imaging platform has the potential to comprehensively and noninvasively unravel long-term effects in preclinical mouse models of allergic airway inflammation and thus benefits our understanding of chronic asthma.

Lung Function Measurement By Optical Contouring

1982 ◽  
Author(s):  
A R. Gourlay ◽  
G Kaye ◽  
D M. Denison ◽  
A J. Peacock ◽  
MD L. Morgan
Keyword(s):  
Lung Function ◽  
Function Measurement ◽  
Lung Function Measurement

Interleukin-32γ Suppresses Allergic Airway Inflammation in Mouse Models of Asthma

2014 ◽  
Vol 50 (6) ◽  
pp. 1021-1030 ◽  
Author(s):  
Bo-Ram Bang ◽  
Hyouk-Soo Kwon ◽  
Soo-Hyun Kim ◽  
Sun-Young Yoon ◽  
Ji-Da Choi ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Mouse Models ◽  
Allergic Airway Inflammation
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