scholarly journals MTHFR c.677C>T Inhibits Cell Proliferation and Decreases Prostate Cancer Susceptibility in the Han Chinese Population in Shanghai

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Jun-Long Wu ◽  
Shu-Xian Zhou ◽  
Rui Zhao ◽  
Xuan Zhang ◽  
Kun Chang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Chinese Population ◽  
Cancer Susceptibility ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Prostate Cancer Susceptibility

scholarly journals Analysis ofMIR155HGvariants and colorectal cancer susceptibility in Han Chinese population

2019 ◽  
Vol 7 (8) ◽  
Author(s):  
Huangfu Wu ◽  
Guisheng He ◽  
Hua Han ◽  
Wei Xiong ◽  
Tao Song ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Chinese Population ◽  
Cancer Susceptibility ◽  
Han Chinese ◽  
Han Chinese Population

scholarly journals The impact of IGF1R SNPs on susceptibility to age-related cataract

2019 ◽  
Author(s):  
Yilei Cui ◽  
Xiaoning Yu ◽  
Xin Zhang ◽  
Yelei Tang ◽  
Xiajing Tang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Chinese Population ◽  
Caspase 3 ◽  
S Phase ◽  
Han Chinese ◽  
Human Lens ◽  
Han Chinese Population ◽  
Age Related ◽  
The Impact

Abstract Background: The insulin-like growth factor 1 receptor (IGF1R) gene is essential for lens development, but the impact of IGF1R on age-related cataract(ARC) has not been investigated. This study explored the association between IGF1R single nucleotide polymorphism (SNP) and ARC susceptibility ,and uncover the underlying mechanism in human lens epithelial (HLE) cells. Methods:A total of 1190 unrelated participants ,comprising 690 ARC patients and 550 healthy individuals in Han Chinese population were recruited and genotyped for target SNP. The X2-test was used to detect genotypic distribution between the patient and control groups and the logistic regression was performed to adjust the age and gender. Meanwhile, in the IGF1R knockdown HLE cells, cell proliferation was detected via CCK-8 analysis. Cell cycle and apoptosis were evaluated by flow cytometry,while the expression of cycle- and apoptosis-related molecules were determined via Q-PCR and Western blot. The Caspase-3 activity was measured using its assay kit. Results: The rs1546713 in IGF1R gene was identified（P =0.046，OR：1.606，CI：1.245,2.071）,which shown a significant relevance with ARC risk under the dominant model. The results demonstrated that IGF1R knockdown inhibited cell proliferation by inducing cell cycle arrest at S phase and promoting apoptosis. Mechanistically, the cell cycle blocked at S phase was linked with the alterations of cyclinA , cyclinB, cyclinE and P21,while the pro-apoptosis function was related to stimulate the activation of Caspase-3 activities and the alteration of Caspase-3,Bcl-2 and Bax expression levels. Conclusions: This study first reported that IGF1R polymorphisms may affect susceptibility to ARCs in Han Chinese population and provided new clues to understanding the pathogenic mechanism of ARCs. Notably, IGF1R is likely a potential target for ARC prevention and treatment.

scholarly journals The Association between LINC00511 Variants and Breast Cancer Susceptibility among the Han Chinese Population

2020 ◽  
Vol 5 (2) ◽  
pp. 87-96
Author(s):  
Fei Fei Chong ◽  
Jing Jing Cao ◽  
Yan Li Wang ◽  
Qiu Yu Sun ◽  
Meng Meng Song ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chinese Population ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Han Chinese ◽  
Han Chinese Population

scholarly journals Polymorphism rs2682818 in miR-618 is associated with colorectal cancer susceptibility in a Han Chinese population

2018 ◽  
Vol 7 (4) ◽  
pp. 1194-1200 ◽  
Author(s):  
Yuetong Chen ◽  
Mulong Du ◽  
Wei Chen ◽  
Lingjun Zhu ◽  
Congye Wu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Chinese Population ◽  
Cancer Susceptibility ◽  
Han Chinese ◽  
Han Chinese Population

IL1RN Polymorphisms Are Associated with a Decreased Risk of Esophageal Cancer Susceptibility in a Chinese Population

Chemotherapy ◽  
2019 ◽  
Vol 64 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Tianchang Wang ◽  
Yan Feng ◽  
Zheng Zhao ◽  
Hao Wang ◽  
Yanbing Zhang ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Risk ◽  
Chinese Population ◽  
Cancer Susceptibility ◽  
Interleukin 1 ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Normal Tissues ◽  
Negative Effect ◽  
And Gender

Background: Recent evidence suggested that IL1RN (interleukin-1 receptor antagonist) polymorphisms increased the susceptibility to cancers. The present study aimed to evaluate whether IL1RN was related to esophageal cancer susceptibility in a Northwest Han Chinese population. Methods: The case-control study was conducted on 384 esophageal cancer patients and 499 healthy controls. We successfully genotyped four SNPs distributed in IL1RN. The Gene Expression Profiling Interactive Analysis (GEPIA) database was used to observe the expression of IL1RN in esophageal cancer tissues and normal tissues. RegulomeDB and HaploReg v4.1 were used to calculate possible functional effects of the polymorphisms. We also used genetic models to detect any potential association between IL1RN variants and esophageal cancer risk. Results: In our study, rs3181052 was associated with a reduced risk of esophageal cancer in the codominant (odds ratio [OR] = 0.70, 95% confidence interval [CI] 0.52–0.93, p = 0.040), the dominant (OR = 0.75, 95% CI 0.57–0.99, p = 0.041), and the overdominant (OR = 0.71, 95% CI 0.54–0.93, p = 0.012) model. The rs452204 was associated with a 0.76-fold (OR = 0.76, 95% CI 0.58–0.99; p = 0.043) decreased esophageal cancer risk under the overdominant model without adjustment. We also found that rs3181052 had a negative effect on esophageal cancer under the overdominant model (OR = 0.72, 95% CI 0.53–0.97, p = 0.033) adjusted for age and gender. In stratified analyses by age >55 years, rs3181052 reduced the risk of esophageal cancer in the dominant and overdominant models. In addition, rs315919 had a remarkable influence on esophageal cancer risk in females, while the association was not significant between rs3181052 and esophageal cancer risk in males. Conclusions: Our study provided the first evidence that IL1RN rs3181052, rs452204, and rs315919 are correlated with a decreased risk of esophageal cancer in a Northwest Han Chinese population. These findings may be useful for the development of early prognostics for esophageal cancer. However, further larger studies on different ethnic populations are warranted to verify these findings.

scholarly journals Evaluating the Association of Eight Polymorphisms with Cancer Susceptibility in a Han Chinese Population

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0132797 ◽  
Author(s):  
Ying Dong ◽  
Jing Chen ◽  
Zhiqiang Chen ◽  
Chaoyong Tian ◽  
Huaisheng Lu ◽  
...  
Keyword(s):  
Chinese Population ◽  
Cancer Susceptibility ◽  
Han Chinese ◽  
Han Chinese Population
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