scholarly journals NMDA receptors in mouse anterior piriform cortex initialize early odor preference learning and L-type calcium channels engage for long-term memory

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Bandhan Mukherjee ◽  
Qi Yuan
Keyword(s):  
Calcium Channels ◽  
Nmda Receptors ◽  
Piriform Cortex ◽  
Preference Learning ◽  
Long Term Memory ◽  
Odor Preference ◽  
Term Memory ◽  
Anterior Piriform Cortex

scholarly journals A role for the anterior piriform cortex in early odor preference learning: evidence for multiple olfactory learning structures in the rat pup

2013 ◽  
Vol 110 (1) ◽  
pp. 141-152 ◽  
Author(s):  
Gillian L. Morrison ◽  
Christine J. Fontaine ◽  
Carolyn W. Harley ◽  
Qi Yuan
Keyword(s):  
Nmda Receptors ◽  
Ex Vivo ◽  
Glutamate Release ◽  
Piriform Cortex ◽  
Long Term Potentiation ◽  
Preference Learning ◽  
Excitatory Postsynaptic Potential ◽  
Adrenergic Blockade ◽  
Odor Preference ◽  
Anterior Piriform Cortex

cFos activation in the anterior piriform cortex (aPC) occurs in early odor preference learning in rat pups ( Roth and Sullivan 2005 ). Here we provide evidence that the pairing of odor as a conditioned stimulus and β-adrenergic activation in the aPC as an unconditioned stimulus generates early odor preference learning. β-Adrenergic blockade in the aPC prevents normal preference learning. Enhancement of aPC cAMP response element-binding protein (CREB) phosphorylation in trained hemispheres is consistent with a role for this cascade in early odor preference learning in the aPC. In vitro experiments suggested theta-burst-mediated long-term potentiation (LTP) at the lateral olfactory tract (LOT) to aPC synapse depends on N-methyl-d-aspartate (NMDA) receptors and can be significantly enhanced by β-adrenoceptor activation, which causes increased glutamate release from LOT synapses during LTP induction. NMDA receptors in aPC are also shown to be critical for the acquisition, but not expression, of odor preference learning, as would be predicted if they mediate initial β-adrenoceptor-promoted aPC plasticity. Ex vivo experiments 3 and 24 h after odor preference training reveal an enhanced LOT-aPC field excitatory postsynaptic potential (EPSP). At 3 h both presynaptic and postsynaptic potentiations support EPSP enhancement while at 24 h only postsynaptic potentiation is seen. LOT-LTP in aPC is excluded by odor preference training. Taken together with earlier work on the role of the olfactory bulb in early odor preference learning, these outcomes suggest early odor preference learning is normally supported by and requires multiple plastic changes at least at two levels of olfactory circuitry.

scholarly journals Specific requirement of NMDA receptors for long-term memory consolidation in Drosophila ellipsoid body

2007 ◽  
Vol 10 (12) ◽  
pp. 1578-1586 ◽  
Author(s):  
Chia-Lin Wu ◽  
Shouzhen Xia ◽  
Tsai-Feng Fu ◽  
Huaien Wang ◽  
Ying-Hsiu Chen ◽  
...  
Keyword(s):  
Nmda Receptors ◽  
Memory Consolidation ◽  
Long Term Memory ◽  
Specific Requirement ◽  
Term Memory ◽  
Ellipsoid Body

scholarly journals Mg2+ Block of Drosophila NMDA Receptors Is Required for Long-Term Memory Formation and CREB-Dependent Gene Expression

Neuron ◽  
2012 ◽  
Vol 74 (5) ◽  
pp. 887-898 ◽  
Author(s):  
Tomoyuki Miyashita ◽  
Yoshiaki Oda ◽  
Junjiro Horiuchi ◽  
Jerry C.P. Yin ◽  
Takako Morimoto ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nmda Receptors ◽  
Memory Formation ◽  
Long Term Memory ◽  
Term Memory

scholarly journals Forgetting of long-term memory requires activation of NMDA receptors, L-type voltage-dependent Ca2+ channels, and calcineurin

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Ricardo Marcelo Sachser ◽  
Fabiana Santana ◽  
Ana Paula Crestani ◽  
Paula Lunardi ◽  
Lizeth Katherine Pedraza ◽  
...  
Keyword(s):  
Nmda Receptors ◽  
Long Term Memory ◽  
Term Memory ◽  
Voltage Dependent ◽  
Ca2 Channels

Conceptual short-term memory (CSTM) supports core claims of Christiansen and Chater

2016 ◽  
Vol 39 ◽  
Author(s):  
Mary C. Potter
Keyword(s):  
Working Memory ◽  
Rapid Serial Visual Presentation ◽  
Language Comprehension ◽  
Short Term Memory ◽  
Visual Presentation ◽  
Long Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Use Of Knowledge

AbstractRapid serial visual presentation (RSVP) of words or pictured scenes provides evidence for a large-capacity conceptual short-term memory (CSTM) that momentarily provides rich associated material from long-term memory, permitting rapid chunking (Potter 1993; 2009; 2012). In perception of scenes as well as language comprehension, we make use of knowledge that briefly exceeds the supposed limits of working memory.

Comparison of Auditory, Language, Memory, and Attention Abilities in Children With and Without Listening Difficulties

2020 ◽  
Vol 29 (4) ◽  
pp. 710-727
Author(s):  
Beula M. Magimairaj ◽  
Naveen K. Nagaraj ◽  
Alexander V. Sergeev ◽  
Natalie J. Benafield
Keyword(s):  
Auditory Processing ◽  
Short Term Memory ◽  
Group Differences ◽  
Long Term Memory ◽  
Short Term ◽  
Significant Group ◽  
Term Memory ◽  
Memory And Attention ◽  
Speed And Accuracy

Objectives School-age children with and without parent-reported listening difficulties (LiD) were compared on auditory processing, language, memory, and attention abilities. The objective was to extend what is known so far in the literature about children with LiD by using multiple measures and selective novel measures across the above areas. Design Twenty-six children who were reported by their parents as having LiD and 26 age-matched typically developing children completed clinical tests of auditory processing and multiple measures of language, attention, and memory. All children had normal-range pure-tone hearing thresholds bilaterally. Group differences were examined. Results In addition to significantly poorer speech-perception-in-noise scores, children with LiD had reduced speed and accuracy of word retrieval from long-term memory, poorer short-term memory, sentence recall, and inferencing ability. Statistically significant group differences were of moderate effect size; however, standard test scores of children with LiD were not clinically poor. No statistically significant group differences were observed in attention, working memory capacity, vocabulary, and nonverbal IQ. Conclusions Mild signal-to-noise ratio loss, as reflected by the group mean of children with LiD, supported the children's functional listening problems. In addition, children's relative weakness in select areas of language performance, short-term memory, and long-term memory lexical retrieval speed and accuracy added to previous research on evidence-based areas that need to be evaluated in children with LiD who almost always have heterogenous profiles. Importantly, the functional difficulties faced by children with LiD in relation to their test results indicated, to some extent, that commonly used assessments may not be adequately capturing the children's listening challenges. Supplemental Material https://doi.org/10.23641/asha.12808607

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