scholarly journals The rs6771157 C/G polymorphism in SCN10A is associated with the risk of atrial fibrillation in a Chinese Han population

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Zhen Fang ◽  
Yue Jiang ◽  
Yifeng Wang ◽  
Yuan Lin ◽  
Yaowu Liu ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Assessment of association of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese Han population

2009 ◽  
Vol 126 (6) ◽  
pp. 843-849 ◽  
Author(s):  
Lisong Shi ◽  
Cong Li ◽  
Chuchu Wang ◽  
Yunlong Xia ◽  
Gang Wu ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals A Variant of IL6R Is Associated with the Recurrence of Atrial Fibrillation after Catheter Ablation in a Chinese Han Population

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e99623 ◽  
Author(s):  
Gang Wu ◽  
Mian Cheng ◽  
He Huang ◽  
Bo Yang ◽  
Hong Jiang ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Catheter Ablation ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Polymorphisms but Not Mutations of theKCNQ1Gene Are Associated with Lone Atrial Fibrillation in the Chinese Han Population

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Hui-min Chu ◽  
Ming-jun Feng ◽  
Yi-gang Li ◽  
Yi-xin Zhang ◽  
Ji-fang Ma ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Risk Factor ◽  
Chinese Han Population ◽  
Chinese Patients ◽  
Delayed Rectifier ◽  
Allelic Association ◽  
Healthy Controls ◽  
Chinese Han ◽  
Han Population ◽  
Common Genetic Variants

Background. Recent studies suggest that mutation of the slow delayed rectifier potassium channel (IKs) contributes to familial atrial fibrillation (FAF). In the current study, we identified common genetic variants ofKCNQ1and explored the potential association betweenKCNQ1polymorphism with lone AF (LAF).Methods. Clinical data and blood samples were collected from 190 Han Chinese patients with sporadic AF and matched healthy controls. Variants of theKCNQ1gene were identified using single-strand conformational polymorphism (SSCP) analysis. A case-control association study inKCNQ1identified six known single-nucleotide polymorphisms (SNPs) during SSCP screening of the 190 LAF patients and 190 healthy controls.Results. One of the SNPs inKCNQ1was strongly associated with LAF; significant allelic association was detected rs59233444 (P=0.013,OR=1.469, 95% confidence interval (CI): 1.083–1.993). A multiple regression analysis indicated that rs59233444 is an independent risk factor for LAF. Twelve new variants were identified inKCNQ1, including one in the 5′-UTR, two in the 3′-UTR, six in introns, two synonymous substitutions, and one missense substitution. Variants c.1009C>T, c.1860C>T, and c.+2285C>T were not present in the 190 controls, and the others were identified in controls at various frequencies.Conclusions. rs59233444, a common SNP but not mutation in the coding regions of theKCNQ1gene, is a risk factor for LAF in Chinese Han population.

scholarly journals Common Variants in the TBX5 Gene Associated with Atrial Fibrillation in a Chinese Han Population

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0160467 ◽  
Author(s):  
Rongfeng Zhang ◽  
Xiaochen Tian ◽  
Lianjun Gao ◽  
Huihua Li ◽  
Xiaomeng Yin ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Chinese Han Population ◽  
Common Variants ◽  
Chinese Han ◽  
Han Population ◽  
Tbx5 Gene

scholarly journals Effect of ABO blood groups on response to warfarin

2019 ◽  
Author(s):  
Shan Zou ◽  
Lishan Wu ◽  
Zeliang Chen ◽  
Hongxiao Li ◽  
Hongjuan Chen ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Venous Thromboembolism ◽  
Blood Group ◽  
Southern China ◽  
Warfarin Dose ◽  
Blood Groups ◽  
Chinese Han Population ◽  
Abo Blood Groups ◽  
Chinese Han ◽  
Han Population

Abstract Background: Numerous studies have demonstrated that patients with non-O blood groups have higher risk for venous thromboembolism than those with O blood group. However, it has remained unknown about the effect of ABO blood groups on warfarin dose requirements in patients receiving anticoagulation in Chinese Han population. The study aimed to investigate the influence of ABO blood groups on warfarin dose requirements in Chinese Han population. Methods: A retrospective study was conducted in the First Affiliated Hospital of Shantou University Medical College in Southern China. Three hundreds and 58 patients with confirmed diagnosis of deep venous thromboembolism and atrial fibrillation were included. Frequency of blood groups and warfarin dose requirements were determined. Results: Of 358 patients with deep venous thromboembolism and atrial fibrillation, 111 patients had blood group A (31.01%), 104 patinets had blood group B (29.05%), 20 patients had blood group AB (5.59%), and 123 patients had blood group O (34.36%). The patients with O blood group had a lower warfarin dose requirements compared with those with A, B and AB blood group. Conclusion: Our study showed that patients with non-O blood groups require higher doses of warfarin.

CASP3 genetic variants and susceptibility to atrial fibrillation in Chinese Han population

2015 ◽  
Vol 183 ◽  
pp. 1-5 ◽  
Author(s):  
Zhurong Luo ◽  
Chenghui Yan ◽  
Ping Yu ◽  
Weiwei Bao ◽  
Xiaoli Shen ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Genetic Variants ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals SNP rs3825214 in TBX5 Is Associated with Lone Atrial Fibrillation in Chinese Han Population

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e64966 ◽  
Author(s):  
Xiaobiao Zang ◽  
Shulong Zhang ◽  
Yunlong Xia ◽  
Sisi Li ◽  
Fenfen Fu ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Lone Atrial Fibrillation ◽  
Han Population

scholarly journals Association of KCNE1 Genetic Polymorphisms with Atrial Fibrillation in a Chinese Han Population

2012 ◽  
Vol 16 (11) ◽  
pp. 1343-1346 ◽  
Author(s):  
Juan Yao ◽  
Yi-Tong Ma ◽  
Xiang Xie ◽  
Fen Liu ◽  
Bang-Dang Chen
Keyword(s):  
Atrial Fibrillation ◽  
Genetic Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population
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