scholarly journals Safety Evaluation and Imaging Properties of Gadolinium-Based Nanoparticles in nonhuman primates

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Shady Kotb ◽  
Joao Piraquive ◽  
Franck Lamberton ◽  
François Lux ◽  
Michael Verset ◽  
...  
Keyword(s):  
Nonhuman Primates ◽  
Safety Evaluation ◽  
Imaging Properties

scholarly journals Radiochemical synthesis and evaluation in nonhuman primates of 3-[11C]methoxy-4-aminopyridine: a novel PET tracer for imaging potassium channels in the CNS

2020 ◽  
Author(s):  
Nicolas J. Guehl ◽  
Ramesh Neelamegam ◽  
Yu-Peng Zhou ◽  
Sung-Hyun Moon ◽  
Maeva Dhaynaut ◽  
...  
Keyword(s):  
Brain Injury ◽  
Nonhuman Primates ◽  
Neurological Diseases ◽  
High Plasma ◽  
K Channel ◽  
Pet Tracer ◽  
Highly Sensitive ◽  
Focal Brain Injury ◽  
Pet Radiotracers ◽  
Imaging Properties

Demyelination, the loss of the protecting sheath of neurons, contributes to disability in many neurological diseases. In order to fully understand its role in different diseases and to monitor treatments aiming at reversing this process, it would be valuable to have PET radiotracers that can detect and quantify molecular changes involved in demyelination. Carbon-11 labeled radiotracers present the advantage of allowing for multiple scans on the same subject in the same day. Here, we describe [11C]3MeO4AP, a novel 11C-labeled version of the K+ channel tracer [18F]3F4AP, and characterize its imaging properties in two nonhuman primates including a monkey with a focal brain injury sustained during a surgical procedure three years prior to imaging. Our findings show that [11C]3MeO4AP is brain permeable, metabolically stable and has high plasma availability. When compared with [18F]3F4AP, [11C]3MeO4AP shows very high correlation in volumes of distribution (VT) confirming a common target. [11C]3MeO4AP shows slower washout than [18F]3F4AP suggesting stronger binding. Finally, similar to [18F]3F4AP, [11C]3MeO4AP is highly sensitive to the focal brain injury. All these features make it a promising radioligand for imaging demyelinated lesions.

scholarly journals Long-Term Safety Evaluation of Continuous Intraocular Delivery of Aflibercept by the Intravitreal Gene Therapy Candidate ADVM-022 in Nonhuman Primates

2021 ◽  
Vol 10 (1) ◽  
pp. 34
Author(s):  
Szilárd Kiss ◽  
Kristina Oresic Bender ◽  
Ruslan N. Grishanin ◽  
Kelly M. Hanna ◽  
Julio D. Nieves ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Nonhuman Primates ◽  
Safety Evaluation

scholarly journals 199. Initial Safety Evaluation of rAAV-hCNGB3 Vectors in Nonhuman Primates

2015 ◽  
Vol 23 ◽  
pp. S79
Author(s):  
Guo-jie Ye ◽  
Ewa Budzynski ◽  
Peter Sonnentag ◽  
Leslie E. McPherson ◽  
T. Michael Nork ◽  
...  
Keyword(s):  
Nonhuman Primates ◽  
Safety Evaluation

Safety Evaluation of Hemagglutinating Virus of Japan–Artificial Viral Envelope Liposomes in Nonhuman Primates

2001 ◽  
Vol 12 (5) ◽  
pp. 469-487 ◽  
Author(s):  
Naoki Tsuboniwa ◽  
Ryuichi Morishita ◽  
Tadamichi Hirano ◽  
Jiro Fujimoto ◽  
Shigenori Furukawa ◽  
...  
Keyword(s):  
Nonhuman Primates ◽  
Safety Evaluation ◽  
Viral Envelope ◽  
Hemagglutinating Virus

Cardiorespiratory safety evaluation in nonhuman primates

2012 ◽  
Vol 66 (2) ◽  
pp. 198
Author(s):  
Michael K. Pugsley ◽  
Aidan K. Curran ◽  
Jennifer L. Ingram-Ross ◽  
Johan Verbeeck ◽  
Mutsumi Miyamoto ◽  
...  
Keyword(s):  
Nonhuman Primates ◽  
Safety Evaluation
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