scholarly journals Easy on-demand single-pass self-assembly and modification to fabricate gold@graphene-based anti-inflammatory nanoplatforms

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Jeong Hoon Byeon ◽  
Jae Hong Park
Keyword(s):  
Self Assembly ◽  
Single Pass ◽  
On Demand ◽  
Anti Inflammatory

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

On-demand shape transformation of polymer vesicles via site-specific isomerization of hydrazone photoswitches in monodisperse hydrophobic oligomers

2021 ◽  
Author(s):  
Valene Wang ◽  
Jiwon Kim ◽  
Junyoung Kim ◽  
Seul Woo Lee ◽  
Kyoung Taek Kim
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Conformational Change ◽  
Self Assembly ◽  
Shape Control ◽  
Shape Transformation ◽  
Site Specific ◽  
On Demand ◽  
Polymer Vesicles

The shape control of nanostructures formed by the solution self-assembly of block copolymers is of significance for drug delivery. In particular, site-specific perturbation resulting in the conformational change of the...

scholarly journals Injectable mechanical pillows for attenuation of load-induced post-traumatic osteoarthritis

2019 ◽  
Vol 6 (4) ◽  
pp. 211-219
Author(s):  
Derek T Holyoak ◽  
Tibra A Wheeler ◽  
Marjolein C H van der Meulen ◽  
Ankur Singh
Keyword(s):  
Knee Joint ◽  
Joint Damage ◽  
Mechanical Trauma ◽  
Protective Effects ◽  
Post Injury ◽  
On Demand ◽  
Post Traumatic ◽  
Anti Inflammatory

Abstract Osteoarthritis (OA) of the knee joint is a degenerative disease initiated by mechanical stress that affects millions of individuals. The disease manifests as joint damage and synovial inflammation. Post-traumatic osteoarthritis (PTOA) is a specific form of OA caused by mechanical trauma to the joint. The progression of PTOA is prevented by immediate post-injury therapeutic intervention. Intra-articular injection of anti-inflammatory therapeutics (e.g. corticosteroids) is a common treatment option for OA before end-stage surgical intervention. However, the efficacy of intra-articular injection is limited due to poor drug retention time in the joint space and the variable efficacy of corticosteroids. Here, we endeavored to characterize a four-arm maleimide-functionalized polyethylene glycol (PEG-4MAL) hydrogel system as a ‘mechanical pillow’ to cushion the load-bearing joint, withstand repetitive loading and improve the efficacy of intra-articular injections of nanoparticles containing dexamethasone, an anti-inflammatory agent. PEG-4MAL hydrogels maintained their mechanical properties after physiologically relevant cyclic compression and released therapeutic payload in an on-demand manner under in vitro inflammatory conditions. Importantly, the on-demand hydrogels did not release nanoparticles under repetitive mechanical loading as experienced by daily walking. Although dexamethasone had minimal protective effects on OA-like pathology in our studies, the PEG-4MAL hydrogel functioned as a mechanical pillow to protect the knee joint from cartilage degradation and inhibit osteophyte formation in an in vivo load-induced OA mouse model.

scholarly journals Bioresponsive microspheres for on‐demand delivery of anti‐inflammatory cytokines for articular cartilage repair

2019 ◽  
Vol 108 (3) ◽  
pp. 722-733 ◽  
Author(s):  
Eunjae Park ◽  
Melanie L. Hart ◽  
Bernd Rolauffs ◽  
Jan P. Stegemann ◽  
Ramkumar T. Annamalai
Keyword(s):  
Articular Cartilage ◽  
Inflammatory Cytokines ◽  
Cartilage Repair ◽  
Articular Cartilage Repair ◽  
On Demand ◽  
Anti Inflammatory

scholarly journals Programming function into mechanical forms by directed assembly of silk bulk materials

2016 ◽  
Vol 114 (3) ◽  
pp. 451-456 ◽  
Author(s):  
Benedetto Marelli ◽  
Nereus Patel ◽  
Thomas Duggan ◽  
Giovanni Perotto ◽  
Elijah Shirman ◽  
...  
Keyword(s):  
Self Assembly ◽  
Biological Function ◽  
Bulk Material ◽  
Directed Assembly ◽  
Water Soluble ◽  
Infrared Light ◽  
Bulk Materials ◽  
Protein Matrix ◽  
On Demand ◽  
Water Based

We report simple, water-based fabrication methods based on protein self-assembly to generate 3D silk fibroin bulk materials that can be easily hybridized with water-soluble molecules to obtain multiple solid formats with predesigned functions. Controlling self-assembly leads to robust, machinable formats that exhibit thermoplastic behavior consenting material reshaping at the nanoscale, microscale, and macroscale. We illustrate the versatility of the approach by realizing demonstrator devices where large silk monoliths can be generated, polished, and reshaped into functional mechanical components that can be nanopatterned, embed optical function, heated on demand in response to infrared light, or can visualize mechanical failure through colorimetric chemistries embedded in the assembled (bulk) protein matrix. Finally, we show an enzyme-loaded solid mechanical part, illustrating the ability to incorporate biological function within the bulk material with possible utility for sustained release in robust, programmably shapeable mechanical formats.

Hybrid Self-Assembly during Evaporation Enables Drop-on-Demand Thin Film Devices

2016 ◽  
Vol 8 (50) ◽  
pp. 34171-34178 ◽  
Author(s):  
J. William Boley ◽  
Seok-Hee Hyun ◽  
Edward L. White ◽  
David H. Thompson ◽  
Rebecca K. Kramer
Keyword(s):  
Thin Film ◽  
Self Assembly ◽  
On Demand ◽  
Drop On Demand ◽  
Thin Film Devices

scholarly journals Bioresponsive Microspheres for On-demand Delivery of Anti-inflammatory Cytokines for Osteoarthritis

2019 ◽  
Author(s):  
Eunjae Park ◽  
Melanie Hart ◽  
Bernd Rolauffs ◽  
Jan P. Stegemann ◽  
Ramkumar T. Annamalai
Keyword(s):  
Inflammatory Cytokines ◽  
Negative Charge ◽  
Crosslinking Density ◽  
Gelatin Microspheres ◽  
Gelatin Matrix ◽  
Surgical Interventions ◽  
On Demand ◽  
Charge Potential ◽  
Clinical Benefits ◽  
Anti Inflammatory

AbstractDespite innovations in surgical interventions, treatment of cartilage injury in osteoarthritic joints remains a challenge due to concomitant inflammation. Obstructing a single dominant inflammatory cytokine have shown remarkable clinical benefits in rheumatoid arthritis, and similar strategies are being suggested to target inflammatory pathways in osteoarthritis (OA). Here we describe the utility of gelatin microspheres that are responsive to arthritic flares, resulting in on-demand, and spatiotemporally controlled release of anti-inflammatory cytokines for cartilage preservation and repair. These microspheres had net negative charge potential to sequester cationic anti-inflammatory cytokines, and the magnitude of the negative charge potential increased with increase in crosslinking density. The enzymatic degradation of the microcarriers was concentration dependent. Release of anti-inflammatory cytokines from the loaded microspheres was directly correlated with the degradation of the gelatin matrix. Exposure of the IL-4 and IL-13 loaded microspheres reduced the inflammation of chondrocytes up to 80%. Hence, the delivery of these microspheres in an osteoarthritic joint can attenuate the stimulation of chondrocytes to secrete catabolic factors including proteinases and nitric oxide. The microsphere format also allows for minimally invasive delivery and is less susceptible to mechanically-induced drug release and are conformant to the intra-articular space. Consequently, bioresponsive microspheres are an effective tool for OA prevention and treatment.

Programmable Self-Assembly Across the Micro and Nano Scales

2005 ◽  
Author(s):  
Karl F. Bo¨hringer
Keyword(s):  
Surface Properties ◽  
Self Assembly ◽  
Surface Forces ◽  
Massively Parallel ◽  
Rfid Tags ◽  
Promising Alternative ◽  
On Demand ◽  
Self Assembling ◽  
Binding Forces ◽  
Realtime Control

Massively parallel self-assembling systems present a promising alternative to conventional manufacturing. Recently, various successful instances of self-assembly have been demonstrated, including applications for commercial products such as RFID tags; however, the full impact of this approach will only be realized once these systems can be programmed or reconfigured on demand (i.e., essentially in software, and without significant hardware changes). In this presentation, we review several projects that lead towards such programmable self-assembling systems. A key concept to achieve this goal is the “programmable surface”, i.e., an engineered surface whose properties (surface forces, hydrophobicity, friction, etc.) can be controlled with high spatial and temporal resolution. We present several projects covering a broad range of issues from realtime control of surface properties, to designs that optimize binding forces between self-assembling components, to computational and algorithmic issues in the modeling of self-assembling systems.

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