scholarly journals Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yoon Sun Cho ◽  
Chih-na Yen ◽  
Joong Sup Shim ◽  
Dong Hoon Kang ◽  
Sang Won Kang ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Kinase Signaling ◽  
S6 Kinase ◽  
Kinase Signaling Pathway

scholarly journals AMPD1 regulates insulin sensitivity through AMPK/mTOR/p70 S6 kinase signaling pathway in skeletal muscles

2015 ◽  
Vol 39 (1) ◽  
pp. 72
Author(s):  
Andreas Avellini K Tandelilin ◽  
Tetsuaki Hirase ◽  
Athanasius Wrin Hudoyo ◽  
Jidong Cheng ◽  
Hiroko Morisaki ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Signaling Pathway ◽  
Skeletal Muscles ◽  
Kinase Signaling ◽  
S6 Kinase ◽  
P70 S6 Kinase ◽  
Kinase Signaling Pathway

scholarly journals Extracellular Zinc Activates p70 S6 Kinase through the Phosphatidylinositol 3-Kinase Signaling Pathway

2000 ◽  
Vol 275 (34) ◽  
pp. 25979-25984 ◽  
Author(s):  
Sunhong Kim ◽  
Youngsun Jung ◽  
Dohoon Kim ◽  
Hyongjong Koh ◽  
Jongkyeong Chung
Keyword(s):  
Signaling Pathway ◽  
Kinase Signaling ◽  
Phosphatidylinositol 3 Kinase ◽  
S6 Kinase ◽  
P70 S6 Kinase ◽  
Kinase Signaling Pathway ◽  
Phosphatidylinositol 3

Possible Mechanism of Human Recombinant Leptin-Induced VEGF A Synthesis via PI3K/Akt/mTOR/S6 Kinase Signaling Pathway while Inducing Angiogenesis: An Analysis Using Chicken Chorioallantoic Membrane Model

2021 ◽  
pp. 1-18
Author(s):  
Reji Manjunathan ◽  
Nalini Devarajan ◽  
Malathi Ragunathan
Keyword(s):  
Signaling Pathway ◽  
Chorioallantoic Membrane ◽  
Signaling Molecules ◽  
Kinase Signaling ◽  
S6 Kinase ◽  
Chick Chorioallantoic Membrane ◽  
Chicken Chorioallantoic Membrane ◽  
Kinase Signaling Pathway ◽  
Kinase Pathway

<b><i>Introduction:</i></b> The present study aimed to realize human recombinant leptin ’s ability to synthesize VEGF A while inducing neovascularization through PI3K/Akt/mTOR/S6 kinase involved signaling pathway. <b><i>Methods:</i></b> To examine the PI3K/Akt/mTOR/S6 kinase pathway involvement in leptin-induced VEGF A synthesis, the chick chorioallantoic membrane (CAM) was incubated with human recombinant leptin and specific inhibitors of the proposed signaling molecules (rapamycin and wortmannin). We analyzed the role of specified signaling molecules in human recombinant leptin-induced physiological angiogenesis via VEGF A synthesis in detail with the support of various methodologies. <b><i>Results:</i></b> Human recombinant leptin’s ability to synthesize VEGF A is diminished significantly in the presence of inhibitors. This observation supported the role of PI3K/Akt/mTOR/S6 kinase signaling molecules in human recombinant leptin-mediated VEGF A synthesis while inducing angiogenesis in CAM. <b><i>Conclusion:</i></b> Synthesis of VEGF A, followed by the growth of new blood vessels, by human recombinant leptin via the activation of the PI3K/Akt/mTOR/S6 kinase signaling pathway reflects mechanistic therapeutic application of human recombinant leptin. The data also signify the role of mTOR and S6 kinase molecules in angiogenesis under a physiological environment.

scholarly journals Agmatine potentiates neuroprotective effects of subthreshold concentrations of ketamine via mTOR/S6 kinase signaling pathway

2018 ◽  
Vol 118 ◽  
pp. 275-285 ◽  
Author(s):  
Mauren K. Tavares ◽  
Suellen dos Reis ◽  
Nicolle Platt ◽  
Isabella A. Heinrich ◽  
Ingrid A.V. Wolin ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Kinase Signaling ◽  
Neuroprotective Effects ◽  
S6 Kinase ◽  
Kinase Signaling Pathway
Sign in / Sign up

Export Citation Format

Share Document