scholarly journals Remote Actuation of Magnetic Nanoparticles For Cancer Cell Selective Treatment Through Cytoskeletal Disruption

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Alyssa M. Master ◽  
Philise N. Williams ◽  
Nikorn Pothayee ◽  
Nipon Pothayee ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Cancer Cell ◽  
Selective Treatment ◽  
Remote Actuation ◽  
Cytoskeletal Disruption

scholarly journals Selective treatment and monitoring of disseminated cancer micrometastases in vivo using dual-function, activatable immunoconjugates

2014 ◽  
Vol 111 (10) ◽  
pp. E933-E942 ◽  
Author(s):  
Bryan Q. Spring ◽  
Adnan O. Abu-Yousif ◽  
Akilan Palanisami ◽  
Imran Rizvi ◽  
Xiang Zheng ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Near Infrared ◽  
Dual Function ◽  
Imaging Method ◽  
Drug Resistant ◽  
Micrometastatic Disease ◽  
Selective Treatment ◽  
Cell Internalization ◽  
Occult Disease

Drug-resistant micrometastases that escape standard therapies often go undetected until the emergence of lethal recurrent disease. Here, we show that it is possible to treat microscopic tumors selectively using an activatable immunoconjugate. The immunoconjugate is composed of self-quenching, near-infrared chromophores loaded onto a cancer cell-targeting antibody. Chromophore phototoxicity and fluorescence are activated by lysosomal proteolysis, and light, after cancer cell internalization, enabling tumor-confined photocytotoxicity and resolution of individual micrometastases. This unique approach not only introduces a therapeutic strategy to help destroy residual drug-resistant cells but also provides a sensitive imaging method to monitor micrometastatic disease in common sites of recurrence. Using fluorescence microendoscopy to monitor immunoconjugate activation and micrometastatic disease, we demonstrate these concepts of “tumor-targeted, activatable photoimmunotherapy” in a mouse model of peritoneal carcinomatosis. By introducing targeted activation to enhance tumor selectively in complex anatomical sites, this study offers prospects for catching early recurrent micrometastases and for treating occult disease.

Magnetic nanoparticles for the measurement of cell mechanics using force-induced remnant magnetization spectroscopy

Nanoscale ◽  
2020 ◽  
Vol 12 (27) ◽  
pp. 14573-14580
Author(s):  
Min Xu ◽  
Xueyan Feng ◽  
Feng Feng ◽  
Hantao Pei ◽  
Ruping Liu ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cell Mechanics ◽  
Magnetic Nanoparticle ◽  
Adhesion Force ◽  
Force Spectroscopy ◽  
Remnant Magnetization ◽  
A Cell ◽  
Novel Method

Interactions of magnetic nanoparticles with cells were investigated from a cell mechanics perspective, and magnetic nanoparticle-based force spectroscopy was developed as a novel method to measure the adhesion force among various cancer cell lines.

scholarly journals Breast cancer cell targeted MR molecular imaging probe: Anti-MUC1 antibody-based magnetic nanoparticles

2017 ◽  
Vol 851 ◽  
pp. 012014 ◽  
Author(s):  
P Moradi Khaniabadi ◽  
A. M. S.A Majid ◽  
M Asif ◽  
B Moradi Khaniabadi ◽  
D Shahbazi-Gahrouei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Nanoparticles ◽  
Molecular Imaging ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Imaging Probe ◽  
Molecular Imaging Probe

Positively Charged Magnetic Nanoparticles for Capture of Circulating Tumor Cells from Clinical Blood Samples

Nano LIFE ◽  
2020 ◽  
Vol 10 (03) ◽  
pp. 1971001 ◽  
Author(s):  
Shengming Wu ◽  
Yilong Wang ◽  
Donglu Shi
Keyword(s):  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cancer Cell ◽  
Detection Sensitivity ◽  
Blood Samples ◽  
Charged Nanoparticles ◽  
Positively Charged

Isolation of circulating tumor cells (CTCs) from cancer patients is of high value for disease monitoring and metastasis diagnosis. Although many new detection methods have emerged in recent years, the detection of CTCs is a current challenge due to lack of specific and sensitive markers. In our previous work, cancer cell surfaces, from over 20 cancer cell lines, have been shown to be negatively-charged regardless of their phenotype by using electrically-charged nanoparticles as a probe. The strong electrostatic interaction between the negative cancer cells and positively charged nanoparticles can well remain in a physiological liquid environment in the presence of serum proteins, enabling effective binding between them. As a result, the cancer cells can be magnetically separated by employing an external magnet. In this technical report, we present preliminary results on the investigation of CTC isolation from both mimetic and clinical blood samples. We show high CTC detection sensitivity by the positively-charged magnetic nanoparticles (PMNs) even at the original concentration of 10 cells per mL mimetic blood sample. The CTCs in the peripheral blood of colorectal cancer patients were isolated and identified by cellular morphology and immunofluorescence staining.

scholarly journals Magnetoliposomes with size controllable insertion of magnetic nanoparticles for efficient targeting of cancer cells

RSC Advances ◽  
2019 ◽  
Vol 9 (26) ◽  
pp. 15053-15060
Author(s):  
Won Il Choi ◽  
Abhishek Sahu ◽  
Frederik R. Wurm ◽  
Seong-Min Jo
Keyword(s):  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Intracellular Delivery ◽  
Specific Targeting

Cationic magnetoliposomes enable to achieve efficient capture of cells and intracellular delivery of oligonucleotides into nucleus through cancer cell-specific targeting.

scholarly journals Remote manipulation of magnetic nanoparticles using magnetic field gradient to promote cancer cell death

2019 ◽  
Vol 125 (4) ◽  
Author(s):  
Mahendran Subramanian ◽  
Arkadiusz Miaskowski ◽  
Stuart Iain Jenkins ◽  
Jenson Lim ◽  
Jon Dobson
Keyword(s):  
Magnetic Field ◽  
Cell Death ◽  
Magnetic Nanoparticles ◽  
Field Gradient ◽  
Cancer Cell ◽  
Magnetic Field Gradient ◽  
Remote Manipulation ◽  
Cancer Cell Death
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