scholarly journals Redox/methylation mediated abnormal DNA methylation as regulators of ambient fine particulate matter-induced neurodevelopment related impairment in human neuronal cells

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Hongying Wei ◽  
Fan Liang ◽  
Ge Meng ◽  
Zhiqing Nie ◽  
Ren Zhou ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Neuronal Cells ◽  
Fine Particulate ◽  
Human Neuronal Cells

scholarly journals DNA methylation of insulin-like growth factor 2 and H19 cluster in cord blood and prenatal air pollution exposure to fine particulate matter

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Congrong Wang ◽  
Michelle Plusquin ◽  
Akram Ghantous ◽  
Zdenko Herceg ◽  
Rossella Alfano ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Particulate Matter ◽  
Growth Factor ◽  
Cord Blood ◽  
Gene Cluster ◽  
Methylation Level ◽  
Fine Particulate Matter ◽  
Methylation Status ◽  
Insulin Like Growth Factor ◽  
Fine Particulate

Abstract Background The IGF2 (insulin-like growth factor 2) and H19 gene cluster plays an important role during pregnancy as it promotes both foetal and placental growth. We investigated the association between cord blood DNA methylation status of the IGF2/H19 gene cluster and maternal fine particulate matter exposure during fetal life. To the best of our knowledge, this is the first study investigating the association between prenatal PM2.5 exposure and newborn DNA methylation of the IGF2/H19. Methods Cord blood DNA methylation status of IGF2/H19 cluster was measured in 189 mother-newborn pairs from the ENVIRONAGE birth cohort (Flanders, Belgium). We assessed the sex-specific association between residential PM2.5 exposure during pregnancy and the methylation level of CpG loci mapping to the IGF2/H19 cluster, and identified prenatal vulnerability by investigating susceptible time windows of exposure. We also addressed the biological functionality of DNA methylation level in the gene cluster. Results Prenatal PM2.5 exposure was found to have genetic region-specific significant association with IGF2 and H19 during specific gestational weeks. The association was found to be sex-specific in both gene regions. Functionality of the DNA methylation was annotated by the association to fetal growth and cellular pathways. Conclusions The results of our study provided evidence that prenatal PM2.5 exposure is associated with DNA methylation in newborns’ IGF2/H19. The consequences within the context of fetal development of future phenotyping should be addressed.

scholarly journals Long-term ambient fine particulate matter and DNA methylation in inflammation pathways: results from the Sister Study

Epigenetics ◽  
2019 ◽  
Vol 15 (5) ◽  
pp. 524-535
Author(s):  
Cuicui Wang ◽  
Katie M. O’Brien ◽  
Zongli Xu ◽  
Dale P. Sandler ◽  
Jack A. Taylor ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Fine Particulate

Fine Particulate Matter Constituents, Nitric Oxide Synthase DNA Methylation and Exhaled Nitric Oxide

2015 ◽  
Vol 49 (19) ◽  
pp. 11859-11865 ◽  
Author(s):  
Renjie Chen ◽  
Liping Qiao ◽  
Huichu Li ◽  
Yan Zhao ◽  
Yunhui Zhang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Dna Methylation ◽  
Particulate Matter ◽  
Nitric Oxide Synthase ◽  
Fine Particulate Matter ◽  
Exhaled Nitric Oxide ◽  
Fine Particulate ◽  
Oxide Synthase

scholarly journals Prenatal fine particulate matter exposure, placental DNA methylation changes, and fetal growth

2021 ◽  
Vol 147 ◽  
pp. 106313
Author(s):  
Yingya Zhao ◽  
Pengpeng Wang ◽  
Yuhan Zhou ◽  
Bin Xia ◽  
Qingyang Zhu ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Particulate Matter ◽  
Fetal Growth ◽  
Fine Particulate Matter ◽  
Fine Particulate ◽  
Particulate Matter Exposure
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