scholarly journals An Auditory BCI System for Assisting CRS-R Behavioral Assessment in Patients with Disorders of Consciousness

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Jun Xiao ◽  
Qiuyou Xie ◽  
Yanbin He ◽  
Tianyou Yu ◽  
Shenglin Lu ◽  
...  
Keyword(s):  
Behavioral Assessment ◽  
Disorders Of Consciousness ◽  
Auditory Bci ◽  
Bci System

scholarly journals Detailed behavioral assessment promotes accurate diagnosis in patients with disorders of consciousness

2015 ◽  
Vol 9 ◽  
Author(s):  
Yael Gilutz ◽  
Avraham Lazary ◽  
Hana Karpin ◽  
Jean-Jacques Vatine ◽  
Tamar Misha ◽  
...  
Keyword(s):  
Behavioral Assessment ◽  
Accurate Diagnosis ◽  
Disorders Of Consciousness

scholarly journals Behavioral assessment in patients with disorders of consciousness: gold standard or fool's gold?

2009 ◽  
pp. 33-48 ◽  
Author(s):  
Joseph T. Giacino ◽  
Caroline Schnakers ◽  
Diana Rodriguez-Moreno ◽  
Kathy Kalmar ◽  
Nicholas Schiff ◽  
...  
Keyword(s):  
Gold Standard ◽  
Behavioral Assessment ◽  
Disorders Of Consciousness

scholarly journals Combined behavioral and electrophysiological evidence for a direct cortical effect of prefrontal tDCS on disorders of consciousness

2019 ◽  
Author(s):  
Bertrand Hermann ◽  
Federico Raimondo ◽  
Lukas Hirsch ◽  
Yu Huang ◽  
Mélanie Denis-Valente ◽  
...  
Keyword(s):  
Electric Fields ◽  
Brain Injuries ◽  
Causal Effect ◽  
Brain Activity ◽  
Vegetative State ◽  
Behavioral Assessment ◽  
Minimally Conscious State ◽  
Conscious State ◽  
Disorders Of Consciousness ◽  
Open Label

ABSTRACTSevere brain injuries can lead to long-lasting disorders of consciousness (DoC) such as vegetative state/unresponsive wakefulness syndrome (VS/UWS) or minimally conscious state (MCS). While behavioral assessment remains the gold standard to determine conscious state, EEG has proven to be a promising complementary tool to monitor the effect of new therapeutics. Encouraging results have been obtained with invasive electrical stimulation of the brain, and recent studies identified transcranial direct current stimulation (tDCS) as an effective approach in randomized controlled trials. This non-invasive and inexpensive tool may turn out to be the preferred treatment option. However, its mechanisms of action and physiological effects on brain activity remain unclear and debated. Here, we stimulated 60 DoC patients with the anode placed over left-dorsolateral prefrontal cortex in a prospective open-label study. Clinical behavioral assessment improved in twelve patients (20%) and none deteriorated. This behavioral response after tDCS coincided with an enhancement of putative EEG markers of consciousness: in comparison with non-responders, responders showed increases of power and long-range cortico-cortical functional connectivity in the theta-alpha band, and a larger and more sustained P300 suggesting improved conscious access to auditory novelty. The EEG changes correlated with electric fields strengths in prefrontal cortices, and no correlation was found on the scalp. Taken together, this prospective intervention in a large cohort of DoC patients strengthens the validity of the proposed EEG signatures of consciousness, and is suggestive of a direct causal effect of tDCS on consciousness.

scholarly journals Language-Related Brain Potentials in Patients With Disorders of Consciousness: A Follow-up Study to Detect “Covert” Language Disorders

2019 ◽  
Vol 33 (7) ◽  
pp. 513-522 ◽  
Author(s):  
Rita Formisano ◽  
Jlenia Toppi ◽  
Monica Risetti ◽  
Marta Aloisi ◽  
Marianna Contrada ◽  
...  
Keyword(s):  
Behavioral Assessment ◽  
Brain Lesion ◽  
Minimally Conscious State ◽  
Language Disorders ◽  
Conscious State ◽  
Disorders Of Consciousness ◽  
Brain Potentials ◽  
Lesion Side ◽  
Minimally Conscious

Background. Language disorders may occur in patients with disorders of consciousness (DoCs), and they could interfere with the behavioral assessment of consciousness and responsiveness. Objective. In this study, we retrospectively explored whether ERP N400 was eventually associated with the presence of aphasia diagnosed in those patients who had evolved into Exit-Minimally Conscious State (E-MCS) at the clinical follow-up. Methods. In this retrospective cohort study, the ERPs elicited by an auditory sentences task were retrospectively examined in a sample of 15 DoC patients diagnosed according to the Coma Recovery Scale–Revised (CRS-R). All these 15 DoC patients underwent a (at least) 1-year clinical follow-up, which included a neuropsychological evaluation to assess language function among other cognitive functions. Ten healthy individuals also underwent the same paradigm to investigate the variability of ERPs characteristics. Results. The N400 ERP component with centroparietal topography was found in 9 of 10 healthy controls in response to the ill-formed sentences. Analysis of patients’ data revealed that (1) a significant N400 component could be detected in 64% (9 of 14 patients) of the DoC patients regardless of the type of DoC; (2) no significant N400 ERP component was retrospectively detected in those E-MCS patients who showed aphasia at the follow-up; and (3) the presence/absence of the N400-ERP component was consistent with the brain lesion side and significantly predict the recovery. Conclusion. These preliminary findings indicate that the absence of N400 was significantly associated with the presence of aphasia diagnosed at the clinical follow-up in E-MCS patients.

scholarly journals Emotion-Related Consciousness Detection in Patients With Disorders of Consciousness Through an EEG-Based BCI System

2018 ◽  
Vol 12 ◽  
Author(s):  
Jiahui Pan ◽  
Qiuyou Xie ◽  
Haiyun Huang ◽  
Yanbin He ◽  
Yuping Sun ◽  
...  
Keyword(s):  
Disorders Of Consciousness ◽  
Bci System
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