scholarly journals Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yasuto Yoneshima ◽  
Nona Abolhassani ◽  
Teruaki Iyama ◽  
Kunihiko Sakumi ◽  
Naoko Shiomi ◽  
...  
Keyword(s):  
Cell Growth ◽  
Mammalian Cells ◽  
Growth Arrest ◽  
Cell Growth Arrest ◽  
Dna Instability ◽  
Dependent Cell

scholarly journals Calcium and S100B Regulation of p53-Dependent Cell Growth Arrest and Apoptosis

1998 ◽  
Vol 18 (7) ◽  
pp. 4272-4281 ◽  
Author(s):  
Christian Scotto ◽  
Jean Christophe Deloulme ◽  
Denis Rousseau ◽  
Edmond Chambaz ◽  
Jacques Baudier
Keyword(s):  
Cell Growth ◽  
Uv Irradiation ◽  
Growth Arrest ◽  
Nuclear Accumulation ◽  
Permissive Temperature ◽  
Wild Type ◽  
Cell Growth Arrest ◽  
Calcium Dependent ◽  
Inhibition Of Growth ◽  
Dependent Cell

ABSTRACT In glial C6 cells constitutively expressing wild-type p53, synthesis of the calcium-binding protein S100B is associated with cell density-dependent inhibition of growth and apoptosis in response to UV irradiation. A functional interaction between S100B and p53 was first demonstrated in p53-negative mouse embryo fibroblasts (MEF cells) by sequential transfection with the S100B and the temperature-sensitive p53Val135 genes. We show that in MEF cells expressing a low level of p53Val135, S100B cooperates with p53Val135 in triggering calcium-dependent cell growth arrest and cell death in response to UV irradiation at the nonpermissive temperature (37.5°C). Calcium-dependent growth arrest of MEF cells expressing S100B correlates with specific nuclear accumulation of the wild-type p53Val135 conformational species. S100B modulation of wild-type p53Val135 nuclear translocation and functions was confirmed with the rat embryo fibroblast (REF) cell line clone 6, which is transformed by oncogenic Ha-ras and overexpression of p53Val135. Ectopic expression of S100B in clone 6 cells restores contact inhibition of growth at 37.5°C, which also correlates with nuclear accumulation of the wild-type p53Val135 conformational species. Moreover, a calcium ionophore mediates a reversible G1 arrest in S100B-expressing REF (S100B-REF) cells at 37.5°C that is phenotypically indistinguishable from p53-mediated G1arrest at the permissive temperature (32°C). S100B-REF cells proceeding from G1 underwent apoptosis in response to UV irradiation. Our data support a model in which calcium signaling and S100B cooperate with the p53 pathways of cell growth inhibition and apoptosis.

scholarly journals Polycomb Group Protein PHF1 Regulates p53-dependent Cell Growth Arrest and Apoptosis

2012 ◽  
Vol 288 (1) ◽  
pp. 529-539 ◽  
Author(s):  
Yang Yang ◽  
Chenji Wang ◽  
Pingzhao Zhang ◽  
Kun Gao ◽  
Dejie Wang ◽  
...  
Keyword(s):  
Cell Growth ◽  
Growth Arrest ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Cell Growth Arrest ◽  
Dependent Cell ◽  
Group Protein

scholarly journals TGF-β-dependent Cell Growth Arrest and Apoptosis

BMB Reports ◽  
2002 ◽  
Vol 35 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Kwang-Youl Lee ◽  
Suk-Chul Bae
Keyword(s):  
Cell Growth ◽  
Growth Arrest ◽  
Cell Growth Arrest ◽  
Dependent Cell

Inducing cell growth arrest and apoptosis by silencing long non-coding RNA PCAT-1 in human bladder cancer

Tumor Biology ◽  
2015 ◽  
Vol 36 (10) ◽  
pp. 7685-7689 ◽  
Author(s):  
Li Liu ◽  
Yuchen Liu ◽  
Chengle Zhuang ◽  
Wen Xu ◽  
Xing Fu ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cell Growth ◽  
Growth Arrest ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Cell Growth Arrest ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Lipid biomarkers of glioma cell growth arrest and cell death detected by 1 H magic angle spinning MRS

2012 ◽  
Vol 25 (11) ◽  
pp. 1253-1262 ◽  
Author(s):  
Ladan Mirbahai ◽  
Martin Wilson ◽  
Christopher S. Shaw ◽  
Carmel McConville ◽  
Roger D. G. Malcomson ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Growth ◽  
Glioma Cell ◽  
Growth Arrest ◽  
Magic Angle Spinning ◽  
Lipid Biomarkers ◽  
Magic Angle ◽  
Cell Growth Arrest ◽  
Angle Spinning
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