scholarly journals Progression of temporal processing deficits in the HIV-1 transgenic rat

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Kristen A. McLaurin ◽  
Rosemarie M. Booze ◽  
Charles F. Mactutus
Keyword(s):  
Temporal Processing ◽  
Transgenic Rat ◽  
Processing Deficits ◽  
Hiv 1

scholarly journals A Gap in Time: Extending our Knowledge of Temporal Processing Deficits in the HIV-1 Transgenic Rat

2016 ◽  
Vol 12 (1) ◽  
pp. 171-179 ◽  
Author(s):  
Kristen A. McLaurin ◽  
Landhing M. Moran ◽  
Hailong Li ◽  
Rosemarie M. Booze ◽  
Charles F. Mactutus
Keyword(s):  
Temporal Processing ◽  
Transgenic Rat ◽  
Processing Deficits ◽  
Hiv 1

scholarly journals It's about time: revisiting temporal processing deficits in dyslexia

2017 ◽  
Vol 21 (2) ◽  
pp. e12530 ◽  
Author(s):  
Laurence Casini ◽  
Catherine Pech-Georgel ◽  
Johannes C. Ziegler
Keyword(s):  
Temporal Processing ◽  
Processing Deficits

scholarly journals Sex Matters: Robust Sex Differences in Signal Detection in the HIV-1 Transgenic Rat

2017 ◽  
Vol 11 ◽  
Author(s):  
Kristen A. McLaurin ◽  
Rosemarie M. Booze ◽  
Charles F. Mactutus ◽  
Amanda J. Fairchild
Keyword(s):  
Sex Differences ◽  
Signal Detection ◽  
Transgenic Rat ◽  
Hiv 1

scholarly journals Unraveling Individual Differences In The HIV-1 Transgenic Rat: Therapeutic Efficacy Of Methylphenidate

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Kristen A. McLaurin ◽  
Hailong Li ◽  
Rosemarie M. Booze ◽  
Amanda J. Fairchild ◽  
Charles F. Mactutus
Keyword(s):  
Individual Differences ◽  
Therapeutic Efficacy ◽  
Transgenic Rat ◽  
Hiv 1

scholarly journals An Immunohistochemical Analysis of Free Radical Stress in the Heart of the HIV-1 Transgenic Rat

2020 ◽  
Vol 26 (S2) ◽  
pp. 1342-1344
Author(s):  
Myla Worthington ◽  
Frank Denaro ◽  
Francesca Benedetti ◽  
Sumiko Williams ◽  
Joseph Bryant ◽  
...  
Keyword(s):  
Free Radical ◽  
Immunohistochemical Analysis ◽  
Transgenic Rat ◽  
Free Radical Stress ◽  
Hiv 1

scholarly journals The HIV-1 Transgenic Rat: Relevance for HIV Noninfectious Comorbidity Research

2020 ◽  
Vol 8 (11) ◽  
pp. 1643
Author(s):  
Frank Denaro ◽  
Francesca Benedetti ◽  
Myla D. Worthington ◽  
Giovanni Scapagnini ◽  
Christopher C. Krauss ◽  
...  
Keyword(s):  
Neuronal Degeneration ◽  
Cell Types ◽  
Transgenic Rat ◽  
Specific Cell ◽  
Rat Tissues ◽  
Local Production ◽  
Specific Tissue ◽  
Effective Models ◽  
The Brain ◽  
Hiv 1

HIV noninfectious comorbidities (NICMs) are a current healthcare challenge. The situation is further complicated as there are very few effective models that can be used for NICM research. Previous research has supported the use of the HIV-1 transgenic rat (HIV-1TGR) as a model for the study of HIV/AIDS. However, additional studies are needed to confirm whether this model has features that would support NICM research. A demonstration of the utility of the HIV-1TGR model would be to show that the HIV-1TGR has cellular receptors able to bind HIV proteins, as this would be relevant for the study of cell-specific tissue pathology. In fact, an increased frequency of HIV receptors on a specific cell type may increase tissue vulnerability since binding to HIV proteins would eventually result in cell dysfunction and death. Evidence suggests that observations of selective cellular vulnerability in this model are consistent with some specific tissue vulnerabilities seen in NICMs. We identified CXCR4-expressing cells in the brain, while specific markers for neuronal degeneration demonstrated that the same neural types were dying. We also confirm the presence of gp120 and Tat by immunocytochemistry in the spleen, as previously reported. However, we observed very rare positive cells in the brain. This underscores the point that gp120, which has been reported as detected in the sera and CSF, is a likely source to which these CXCR4-positive cells are exposed. This alternative appears more probable than the local production of gp120. Further studies may indicate some level of local production, but that will not eliminate the role of receptor-mediated pathology. The binding of gp120 to the CXCR4 receptor on neurons and other neural cell types in the HIV-1TGR can thus explain the phenomena of selective cell death. Selective cellular vulnerability may be a contributing factor to the development of NICMs. Our data indicate that the HIV-1TGR can be an effective model for the studies of HIV NICMs because of the difference in the regional expression of CXCR4 in rat tissues, thus leading to specific organ pathology. This also suggests that the model can be used in the development of therapeutic options.

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