scholarly journals Proteomics-based identification and validation of novel plasma biomarkers phospholipid transfer protein and mannan-binding lectin serine protease-1 in age-related macular degeneration

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Hye-Jung Kim ◽  
Seong Joon Ahn ◽  
Se Joon Woo ◽  
Hye Kyoung Hong ◽  
Eui Jin Suh ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Serine Protease ◽  
Age Related Macular Degeneration ◽  
Phospholipid Transfer Protein ◽  
Plasma Biomarkers ◽  
Transfer Protein ◽  
Age Related ◽  
Phospholipid Transfer ◽  
Mannan Binding Lectin ◽  
Binding Lectin

scholarly journals Plasma biomarkers of the amyloid pathway are associated with geographic atrophy secondary to age-related macular degeneration

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0236283
Author(s):  
Kameran Lashkari ◽  
Gianna C. Teague ◽  
Ursula Beattie ◽  
Joanna Betts ◽  
Sanjay Kumar ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Geographic Atrophy ◽  
Age Related Macular Degeneration ◽  
Plasma Biomarkers ◽  
Age Related

scholarly journals Plasma Biomarkers of Oxidative Stress and Genetic Variants in Age-Related Macular Degeneration

2012 ◽  
Vol 153 (3) ◽  
pp. 460-467.e1 ◽  
Author(s):  
Milam A. Brantley ◽  
Melissa P. Osborn ◽  
Barton J. Sanders ◽  
Kasra A. Rezaei ◽  
Pengcheng Lu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Macular Degeneration ◽  
Genetic Variants ◽  
Age Related Macular Degeneration ◽  
Plasma Biomarkers ◽  
Age Related ◽  
Biomarkers Of Oxidative Stress

The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody

2015 ◽  
Vol 472 (2) ◽  
pp. 169-181 ◽  
Author(s):  
Claudio Ciferri ◽  
Michael T. Lipari ◽  
Wei-Ching Liang ◽  
Alberto Estevez ◽  
Julie Hang ◽  
...  
Keyword(s):  
High Temperature ◽  
Macular Degeneration ◽  
Serine Protease ◽  
Antibody Binding ◽  
Age Related Macular Degeneration ◽  
Inhibitory Mechanism ◽  
Blocking Antibody ◽  
Temperature Requirement ◽  
Age Related

The high temperature requirement A1 (HtrA1) protease is implicated in many pathological processes, including the age-related macular degeneration (AMD). We identified a blocking antibody binding to the HTRA1 complex trimer and were able to elucidate an unusual inhibitory mechanism by structural and biochemical experiments.

scholarly journals Plasma Biomarkers of Reticular Pseudodrusen and the Risk of Progression to Advanced Age-Related Macular Degeneration

2020 ◽  
Vol 9 (10) ◽  
pp. 12
Author(s):  
Anne M. Lynch ◽  
Brandie D. Wagner ◽  
Alan G. Palestine ◽  
Nebojsa Janjic ◽  
Jennifer L. Patnaik ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Advanced Age ◽  
Plasma Biomarkers ◽  
Reticular Pseudodrusen ◽  
Age Related ◽  
Risk Of Progression

Associations of cholesteryl ester transfer protein (CETP) gene variants with predisposition to age-related macular degeneration

Gene ◽  
2017 ◽  
Vol 636 ◽  
pp. 30-35 ◽  
Author(s):  
Rasa Liutkeviciene ◽  
Alvita Vilkeviciute ◽  
Greta Streleckiene ◽  
Loresa Kriauciuniene ◽  
Romanas Chaleckis ◽  
...  
Keyword(s):  
Cholesteryl Ester ◽  
Macular Degeneration ◽  
Cholesteryl Ester Transfer Protein ◽  
Age Related Macular Degeneration ◽  
Gene Variants ◽  
Transfer Protein ◽  
Age Related

scholarly journals HtrA1 serine protease expression levels on age-related macular degeneration (AMD) patients in Yogyakarta

2020 ◽  
Vol 28 ◽  
pp. 02004
Author(s):  
Supanji Supanji ◽  
Ayudha Bahana Ilham Perdamaian ◽  
Anindita Dianratri ◽  
Anditta Syifarahmah ◽  
Tri Wahyu Widayanti ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Serine Protease ◽  
Study Groups ◽  
Statistical Correlation ◽  
Age Related Macular Degeneration ◽  
P Value ◽  
Restriction Enzyme Digestion ◽  
Age Related ◽  
The Usa ◽  
The Relationship

This research aims to investigate the HtrA1 serine protease circulating level of Age-related Macular Degeneration (AMD) patients in Yogyakarta, Indonesia. This study was conducted from January to August 2019 which included 38 AMD patients and 16 Non-AMD patients/controls (two groups). Baseline data and blood sample were collected. ELISA assay was used to measure the HtrA1 serine protease circulating level on both groups. SNP genotyping of rs10490924 was using restriction enzyme digestion. This study used The IBM SPSS® version 24 (Chicago, The USA) to determine the relationship between HtrA1 expression level and AMD incidence. AMD patients had higher HtrA1 serine protease level (35.31) than controls (30.08). However, there is no association found between HtrA1 serine protease level and AMD incidence (p-value>0.05, CI 95 %). However, HtrA1 serine protease did not associate positively to AMD incidence in Yogyakarta samples. Further analysis by grouping AMD patient based on the rs10490924 genotype show no statistical correlation between HTRA1 to the incidence of AMD. This result might be due to the lack of samples in the study groups. Future studies with larger number of samples are advised to better see the association between Htra1 serine protease level and AMD incidence.

scholarly journals Circulating levels of mannose-binding lectin (MBL) in age-related macular degeneration

2018 ◽  
Vol 81 (2) ◽  
Author(s):  
Fernando M. Pradella ◽  
Renato Nisihara ◽  
Mario T. Sato ◽  
Alexandre A. Grandinetti ◽  
Sergio B. Novello ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Mannose Binding Lectin ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Mannose Binding ◽  
Circulating Levels ◽  
Binding Lectin

Age related macular degeneration (ARMD) – pathophysiological and clinical features and therapeutic concepts

2001 ◽  
Vol 58 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Ursula Körner-Stiefbold
Keyword(s):  
Macular Degeneration ◽  
Clinical Features ◽  
Altersbedingte Makuladegeneration ◽  
Age Related Macular Degeneration ◽  
Genetische Faktoren ◽  
Age Related ◽  
Therapeutic Concepts

Die altersbedingte Makuladegeneration (AMD) ist eine der häufigsten Ursachen für einen irreversiblen Visusverlust bei Patienten über 65 Jahre. Nahezu 30% der über 75-Jährigen sind von einer AMD betroffen. Trotz neuer Erkenntnisse in der Grundlagenforschung ist die Ätiologie, zu der auch genetische Faktoren gehören, noch nicht völlig geklärt. Aus diesem Grund sind die Behandlungsmöglichkeiten zum jetzigen Zeitpunkt noch limitiert, so dass man lediglich von Therapieansätzen sprechen kann. Die derzeit zur Verfügung stehenden Möglichkeiten wie medikamentöse, chirurgische und laser- und strahlentherapeutische Maßnahmen werden beschrieben.

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