Erratum: Cannabis and tolerance: acute drug impairment as a function of cannabis use history

J. G. Ramaekers; J. H. van Wel; D. B. Spronk; S. W. Toennes; K. P. C. Kuypers; E. L. Theunissen; R. J. Verkes

doi:10.1038/srep31939

Cannabis and tolerance: acute drug impairment as a function of cannabis use history

Scientific Reports ◽

10.1038/srep26843 ◽

2016 ◽

Vol 6 (1) ◽

Cited By ~ 21

Author(s):

J. G. Ramaekers ◽

J. H. van Wel ◽

D. B. Spronk ◽

S. W. Toennes ◽

K. P. C. Kuypers ◽

...

Keyword(s):

Impulse Control ◽

Drug Users ◽

Cannabis Use ◽

Psychomotor Function ◽

Acute Effects ◽

Neurocognitive Performance ◽

School Work ◽

Policy Debates ◽

Neurocognitive Test ◽

Drug Impairment

Abstract Cannabis use history as predictor of neurocognitive response to cannabis intoxication remains subject to scientific and policy debates. The present study assessed the influence of cannabis on neurocognition in cannabis users whose cannabis use history ranged from infrequent to daily use. Drug users (N = 122) received acute doses of cannabis (300 μg/kg THC), cocaine HCl (300 mg) and placebo. Cocaine served as active control for demonstrating neurocognitive test sensitivity. Executive function, impulse control, attention, psychomotor function and subjective intoxication were significantly worse after cannabis administration relative to placebo. Cocaine improved psychomotor function and attention, impaired impulse control and increased feelings of intoxication. Acute effects of cannabis and cocaine on neurocognitive performance were similar across cannabis users irrespective of their cannabis use history. Absence of tolerance implies that that frequent cannabis use and intoxication can be expected to interfere with neurocognitive performance in many daily environments such as school, work or traffic.

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Teen Cannabis Use Tied to Adult Anxiety, Depression

Pediatric News ◽

10.1016/s0031-398x(07)70254-0 ◽

2007 ◽

Vol 41 (4) ◽

pp. 41

Author(s):

HEIDI SPLETE

Keyword(s):

Cannabis Use ◽

Anxiety Depression

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Cannabis Use and Dependence

10.1017/cbo9780511470219 ◽

2002 ◽

Cited By ~ 111

Author(s):

Wayne Hall ◽

Rosalie Liccardo Pacula

Keyword(s):

Cannabis Use

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Cannabis use in Switzerland: The role of attribution of drug use to friends, urbanization and repression 1The study was supported by the Swiss Federal Office of Public Health (Bundesamt für Gesundheit BAG) Grant 316.96.5980.

Swiss Journal of Psychology ◽

10.1024//1421-0185.60.2.99 ◽

2001 ◽

Vol 60 (2) ◽

pp. 99-107 ◽

Cited By ~ 7

Author(s):

Holger Schmid

Keyword(s):

Drug Use ◽

Urban Areas ◽

Hierarchical Linear Model ◽

Cannabis Use ◽

School Aged Children ◽

Structural Variables ◽

Hbsc Study ◽

Nationally Representative ◽

Highly Correlated ◽

Individual Use

Cannabis use does not show homogeneous patterns in a country. In particular, urbanization appears to influence prevalence rates, with higher rates in urban areas. A hierarchical linear model (HLM) was employed to analyze these structural influences on individuals in Switzerland. Data for this analysis were taken from the Switzerland survey of Health Behavior in School-Aged Children (HBSC) Study, the most recent survey to assess drug use in a nationally representative sample of 3473 15-year-olds. A total of 1487 male and 1620 female students indicated their cannabis use and their attributions of drug use to friends. As second level variables we included address density in the 26 Swiss Cantons as an indicator of urbanization and officially recorded offences of cannabis use in the Cantons as an indicator of repressive policy. Attribution of drug use to friends is highly correlated with cannabis use. The correlation is even more pronounced in urban Cantons. However, no association between recorded offences and cannabis use was found. The results suggest that structural variables influence individuals. Living in an urban area effects the attribution of drug use to friends. On the other hand repressive policy does not affect individual use.

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Cannabis-associated arteritis

VASA ◽

10.1024/0301-1526/a000004 ◽

2010 ◽

Vol 39 (1) ◽

pp. 43-53 ◽

Cited By ~ 17

Author(s):

Grotenhermen

Keyword(s):

Systematic Review ◽

Case Reports ◽

Case Series ◽

Cardiovascular Effects ◽

Causative Factor ◽

Cannabis Use ◽

Thromboangiitis Obliterans ◽

Pathological Features ◽

Scientific Support ◽

Clinical And Pathological Features

Background: To investigate the hypothesis that cases of arteritis similar to thromboangiitis obliterans (TAO) and associated with the use of cannabis were caused by cannabis or THC (dronabinol), or that cannabis use is a co-factor of TAO. Patients and methods: A systematic review on case reports and the literature on so-called cannabis arteritis, TAO, and cardiovascular effects of cannabinoids was conducted. Results: Fifteen reports with 57 cases of an arteritis associated with the use of cannabis and two additional case series of TAO, in which some patients also used cannabis, were identified. Clinical and pathological features of cannabis-associated arteritis do not differ from TAO and the major risk factor of TAO, tobacco use, was present in most, if not in all of these cases. The proposed pathophysiological mechanisms for the development of an arteritis by cannabis use are not substantiated. Conclusions: The hypothesis of cannabis being a causative factor or co-factor of TAO or an arteritis similar to TAO is not supported by the available evidence. The use of the term cannabis arteritis should be avoided until or unless more convincing scientific support is forthcoming.

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