scholarly journals Two proteolytic fragments of menin coordinate the nuclear transcription and postsynaptic clustering of neurotransmitter receptors during synaptogenesis between Lymnaea neurons

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Angela M. Getz ◽  
Frank Visser ◽  
Erin M. Bell ◽  
Fenglian Xu ◽  
Nichole M. Flynn ◽  
...  
Keyword(s):  
Neurotransmitter Receptors ◽  
Lymnaea Neurons

scholarly journals GRKs as Modulators of Neurotransmitter Receptors

Cells ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 52
Author(s):  
Eugenia V. Gurevich ◽  
Vsevolod V. Gurevich
Keyword(s):  
G Protein ◽  
General Model ◽  
G Protein Coupled Receptors ◽  
Receptor Internalization ◽  
Neurotransmitter Receptors ◽  
Receptor Subtype ◽  
Receptor Subtypes ◽  
Receptor Kinase ◽  
G Protein Coupled ◽  
Homologous Desensitization

Many receptors for neurotransmitters, such as dopamine, norepinephrine, acetylcholine, and neuropeptides, belong to the superfamily of G protein-coupled receptors (GPCRs). A general model posits that GPCRs undergo two-step homologous desensitization: the active receptor is phosphorylated by kinases of the G protein-coupled receptor kinase (GRK) family, whereupon arrestin proteins specifically bind active phosphorylated receptors, shutting down G protein-mediated signaling, facilitating receptor internalization, and initiating distinct signaling pathways via arrestin-based scaffolding. Here, we review the mechanisms of GRK-dependent regulation of neurotransmitter receptors, focusing on the diverse modes of GRK-mediated phosphorylation of receptor subtypes. The immediate signaling consequences of GRK-mediated receptor phosphorylation, such as arrestin recruitment, desensitization, and internalization/resensitization, are equally diverse, depending not only on the receptor subtype but also on phosphorylation by GRKs of select receptor residues. We discuss the signaling outcome as well as the biological and behavioral consequences of the GRK-dependent phosphorylation of neurotransmitter receptors where known.

Nonlinear activity of identified Lymnaea neurons

2000 ◽  
Vol 51 (2-4) ◽  
pp. 237-242
Author(s):  
M. Barbi ◽  
S. Chillemi ◽  
A. Di Garbo ◽  
G. Molnár ◽  
A. Szűcs
Keyword(s):  
Lymnaea Neurons

Two types of A-channels in Lymnaea neurons

1995 ◽  
Vol 146 (3) ◽  
Author(s):  
S.I. Alekseev ◽  
M.C. Ziskin
Keyword(s):  
Lymnaea Neurons

Phospholipase C isozymes selectively couple to specific neurotransmitter receptors

Nature ◽  
10.1038/38508 ◽  
1997 ◽  
Vol 389 (6648) ◽  
pp. 290-293 ◽  
Author(s):  
Daesoo Kim ◽  
Ki Sun Jun ◽  
Seong Beom Lee ◽  
Nae-Gyu Kang ◽  
Do Sik Min ◽  
...  
Keyword(s):  
Phospholipase C ◽  
Neurotransmitter Receptors
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