scholarly journals RNA sequencing from neural ensembles activated during fear conditioning in the mouse temporal association cortex

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Jin-Hyung Cho ◽  
Ben S. Huang ◽  
Jesse M. Gray
Keyword(s):  
Fear Conditioning ◽  
Rna Sequencing ◽  
Association Cortex ◽  
Temporal Association ◽  
Neural Ensembles

scholarly journals Increased neural efficiency in the temporal association cortex as the result of semantic task repetition

2007 ◽  
Vol 29 (8) ◽  
pp. 922-930 ◽  
Author(s):  
Christine Whatmough ◽  
Jim Nikelski ◽  
Oury Monchi ◽  
Howard Chertkow
Keyword(s):  
Association Cortex ◽  
Temporal Association ◽  
Task Repetition ◽  
Semantic Task ◽  
Neural Efficiency

scholarly journals Entorhinal cortical Island cells regulate temporal association learning with long trace period

2021 ◽  
Vol 28 (9) ◽  
pp. 319-328
Author(s):  
Jun Yokose ◽  
William D. Marks ◽  
Naoki Yamamoto ◽  
Sachie K. Ogawa ◽  
Takashi Kitamura
Keyword(s):  
Fear Conditioning ◽  
Critical Role ◽  
Pyramidal Cells ◽  
Temporal Association ◽  
Association Learning ◽  
Trace Fear Conditioning ◽  
Dorsal Hippocampal ◽  
Neural Input ◽  
Hippocampal Ca1 ◽  
Trace Fear

Temporal association learning (TAL) allows for the linkage of distinct, nonsynchronous events across a period of time. This function is driven by neural interactions in the entorhinal cortical–hippocampal network, especially the neural input from the pyramidal cells in layer III of medial entorhinal cortex (MECIII) to hippocampal CA1 is crucial for TAL. Successful TAL depends on the strength of event stimuli and the duration of the temporal gap between events. Whereas it has been demonstrated that the neural input from pyramidal cells in layer II of MEC, referred to as Island cells, to inhibitory neurons in dorsal hippocampal CA1 controls TAL when the strength of event stimuli is weak, it remains unknown whether Island cells regulate TAL with long trace periods as well. To understand the role of Island cells in regulating the duration of the learnable trace period in TAL, we used Pavlovian trace fear conditioning (TFC) with a 60-sec long trace period (long trace fear conditioning [L-TFC]) coupled with optogenetic and chemogenetic neural activity manipulations as well as cell type-specific neural ablation. We found that ablation of Island cells in MECII partially increases L-TFC performance. Chemogenetic manipulation of Island cells causes differential effectiveness in Island cell activity and leads to a circuit imbalance that disrupts L-TFC. However, optogenetic terminal inhibition of Island cell input to dorsal hippocampal CA1 during the temporal association period allows for long trace intervals to be learned in TFC. These results demonstrate that Island cells have a critical role in regulating the duration of time bridgeable between associated events in TAL.

Temporal Association Cortex - A Cortical Hub for Processing Infant Vocalizations

2019 ◽  
Author(s):  
Gen-ichi Tasaka ◽  
Libi Feigin ◽  
Ido Maor ◽  
Maya Groysman ◽  
Laura A. DeNardo ◽  
...  
Keyword(s):  
Association Cortex ◽  
Temporal Association ◽  
Infant Vocalizations

Single-unit activity in temporal association cortex of the monkey.

1967 ◽  
Vol 30 (4) ◽  
pp. 833-843 ◽  
Author(s):  
C G Gross ◽  
P H Schiller ◽  
C Wells ◽  
G L Gerstein
Keyword(s):  
Unit Activity ◽  
Single Unit ◽  
Association Cortex ◽  
Temporal Association ◽  
Single Unit Activity

scholarly journals Emotional learning retroactively enhances item memory but distorts source attributions

2020 ◽  
Author(s):  
Augustin C. Hennings ◽  
Jarrod Lewis-Peacock ◽  
Joseph E. Dunsmoor
Keyword(s):  
Fear Conditioning ◽  
Source Memory ◽  
Semantic Category ◽  
Emotional Learning ◽  
Item Memory ◽  
Temporal Association ◽  
Temporal Context ◽  
Emotional Context ◽  
Emotional Event ◽  
Powerful Learning

An adaptive memory system should prioritize select information surrounding a powerful learning event that may prove useful for predicting future meaningful events. The behavioral tagging hypothesis provides a mechanistic framework to interpret how weak experiences persist as durable memories through temporal association with a strong experience. Importantly, memories are composed of multiple elements, and different mnemonic aspects of the same experience may be uniquely affected by mechanisms that retroactively modulate weakly encoded memory. Here we investigated how emotional learning affects item and source memory for related events encoded close in time. Participants encoded trial-unique category exemplars before, during, and after Pavlovian fear conditioning. Results showed selective retroactive enhancements in 24-hour item memory were accompanied by a bias to misattribute items to the temporal context of fear conditioning. The strength of this source memory bias correlated with participants’ retroactive item memory enhancement, and source misattribution to the emotional context predicted whether items were remembered overall. In the framework of behavioral tagging: memory attribution was biased to the temporal context of the stronger event (fear conditioning) that provided the putative source of memory stabilization for the weaker event (non-emotional learning). We additionally found that fear conditioning selectively and retroactively enhanced stimulus typicality ratings for related items, and that stimulus typicality also predicted overall item memory. Collectively, these results provide new evidence that items related to an emotional event are misattributed to the temporal context of the emotional event and judged to be more representative of their semantic category. Both processes may help facilitate memory retrieval for related events encoded close in time.

scholarly journals The Fusion of Mental Imagery and Sensation in the Temporal Association Cortex

2014 ◽  
Vol 34 (41) ◽  
pp. 13684-13692 ◽  
Author(s):  
Christopher C. Berger ◽  
H. Henrik Ehrsson
Keyword(s):  
Mental Imagery ◽  
Association Cortex ◽  
Temporal Association

scholarly journals The Temporal Association Cortex Plays a Key Role in Auditory-Driven Maternal Plasticity

Neuron ◽  
2020 ◽  
Vol 107 (3) ◽  
pp. 566-579.e7 ◽  
Author(s):  
Gen-ichi Tasaka ◽  
Libi Feigin ◽  
Ido Maor ◽  
Maya Groysman ◽  
Laura A. DeNardo ◽  
...  
Keyword(s):  
Association Cortex ◽  
Temporal Association

Changes in the Regional Cerebral Perfusion After Eye Movement Desensitization and Reprocessing: A SPECT Study of Two Cases

2007 ◽  
Vol 1 (1) ◽  
pp. 24-30 ◽  
Author(s):  
Dong-Hoon Oh ◽  
Joonho Choi
Keyword(s):  
Prefrontal Cortex ◽  
Eye Movement ◽  
Cerebral Perfusion ◽  
Single Photon ◽  
Photon Emission ◽  
Association Cortex ◽  
Temporal Association ◽  
Control Group ◽  
Dorsolateral Prefrontal ◽  
Limbic Area

Eye movement desensitization and reprocessing (EMDR) has emerged as a promising new treatment for trauma and other anxiety-based disorders. However, the neurobiological mechanism of EMDR has not been well understood. This study reports changes in the resting regional cerebral blood flow after successful EMDR treatment in two patients with posttraumatic stress disorder (PTSD). Brain 99mTc-ECD-SPECT (Technetium 99m–ethyl cysteinate dimmer–single photon emission computerized tomography) was performed before and after EMDR, and, in addition, a pre- and posttreatment comparison was made with 10 non-PTSD participants as a control group. After EMDR, cerebral perfusion increased in bilateral dorsolateral prefrontal cortex and decreased in the temporal association cortex. The differences between participants and normal controls also decreased. Changes appeared mainly in the limbic area and the prefrontal cortex. These results are in line with current understanding of neurobiology of PTSD. EMDR treatment appears to reverse the functional imbalance between the limbic area and the prefrontal cortex.

scholarly journals Sparse Coding in Temporal Association Cortex Improves Complex Sound Discriminability

2020 ◽  
Author(s):  
L Feigin ◽  
G Tasaka ◽  
I Maor ◽  
A Mizrahi
Keyword(s):  
Auditory Cortex ◽  
Population Analysis ◽  
Primary Auditory Cortex ◽  
Association Cortex ◽  
Temporal Association ◽  
Neuronal Responses ◽  
Complex Sound ◽  
Pure Tones ◽  
Auditory Cortices ◽  
Auditory Field

AbstractThe mouse auditory cortex is comprised of several auditory fields spanning the dorso-ventral axis of the temporal lobe. The ventral most auditory field is the temporal association cortex (TeA), which remains largely unstudied. Using Neuropixels probes, we simultaneously recorded from primary auditory cortex (AUDp), secondary auditory cortex (AUDv) and TeA, characterizing neuronal responses to pure tones and frequency modulated (FM) sweeps in awake head-restrained mice. As compared to primary and secondary auditory cortices, single unit responses to pure tones in TeA were sparser, delayed and prolonged. Responses to FMs were also sparser. Population analysis showed that the sparser responses in TeA render it less sensitive to pure tones, yet more sensitive to FMs. When characterizing responses to pure tones under anesthesia, the distinct signature of TeA was changed considerably as compared to that in awake mice, implying that responses in TeA are strongly modulated by non-feedforward connections. Together with the known connectivity profile of TeA, these findings suggest that sparse representation of sounds in TeA supports selectivity to higher-order features of sounds and more complex auditory computations.

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